Chidamide

Product Name: Chidamide
CAS No.: 743420-02-2
Chemical Name: Chidamide
Synonyms: CS-1764;Chidamide;HBI-8000);HDAC-IN-7;Chidamide D4;Chidamide(CS055;chidamide analog;Chidamide impurity;Chidamide USP/EP/BP;Tucidinostat (Chidamide)
CBNumber: CB42590631
Molecular Formula: C22H19FN4O2
Formula Weight: 390.41
MOL File: 743420-02-2.mol

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Chidamide Property

Melting point:: >145°C (dec.)
Boiling point:: 600.2±55.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 12.30±0.70(Predicted)
color: Off-White to Pale Beige
InChI: InChI=1S/C22H19FN4O2/c23-18-8-9-19(24)20(12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)
InChIKey: WXHHICFWKXDFOW-UHFFFAOYSA-N
SMILES: C(NC1=CC(F)=CC=C1N)(=O)C1=CC=C(CNC(=O)C=CC2=CC=CN=C2)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13686
Product name: Chidamide
Purity: ≥98%
Packaging: 1mg
Price: $39
Updated: 2021/12/16

Cayman Chemical

Product number: 13686
Product name: Chidamide
Purity: ≥98%
Packaging: 5mg
Price: $166
Updated: 2021/12/16

Cayman Chemical

Product number: 13686
Product name: Chidamide
Purity: ≥98%
Packaging: 10mg
Price: $293
Updated: 2021/12/16

Cayman Chemical

Product number: 13686
Product name: Chidamide
Purity: ≥98%
Packaging: 25mg
Price: $634
Updated: 2021/12/16

Usbiological

Product number: 445836
Product name: De-4-fluoro 5-Fluoro Chidamide
Packaging: 25mg
Price: $460
Updated: 2021/12/16

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Chidamide Chemical Properties,Usage,Production

Description

Chidamide (Epidaza®), a class I HDAC inhibitor, was discovered and developed by ChipScreen and approved by the CFDA in December 2014 for the treatment of recurrent of refractory peripheral T-cell lymphoma. Chidamide, also known as CS055 and HBI- 8000, is an orally bioavailable benzamide type inhibitor of HDAC isoenzymes class I 1–3, as well as class IIb 10, with potential antineoplastic activity. It selectively binds to and inhibits HDAC, leading to an increase in acetylation levels of histone protein H3.74 This agent also inhibits the expression of signaling kinases in the PI3K/ Akt and MAPK/Ras pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. Currently, phases I and II clinical trials are underway for the treatment of non-small cell lung cancer and for the treatment of breast cancer, respectively.

Uses

De-5-fluoro 4-Fluorochidamide is an analogue of Chidamide (CAS 743420-02-0), a hitsone deacetylase inhibitor (HDACI) that enhances gemcitabine (G305000) cytotoxicity in pancreatic cancer cells.

Synthesis

The scalable synthetic approach to chidamide very closely follows the discovery route. The sequence began with the condensation of commercial nicotinaldehyde (52) and malonic acid (53) in a mixture of pyridine and piperidine. Next, activation of acid 54 with N,N0-carbonyldiimidazole (CDI) and subsequent reaction with 4-aminomethyl benzoic acid (55) under basic conditions afforded amide 56 in 82% yield. Finally, activation of 56 with CDI prior to treatment with 4-fluorobenzene- 1,2-diamine (57) and subsequent treatment with TFA and THF yielded chidamide (VIII) in 38% overall yield from 52. However, no publication reported that mono-N-Boc-protected bis-aniline was used to approach Chidamide.

References

[1] gong k, xie j, yi h, li w. cs055 (chidamide/hbi-8000), a novel histone deacetylase inhibitor, induces g1 arrest, ros-dependent apoptosisand differentiation in human leukaemia cells. biochem j. 2012 may 1;443(3):735-46.
[2] wang h1, guo y, fu m, liang x, etal. , antitumor activity of chidamide in hepatocellular carcinoma cell lines. mol med rep. 2012 jun;5(6):1503-8.

Chidamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Chidamide Suppliers

China 134 India 1 United States 16 Global 151

Shenzhen Weixin Pharmaceutical Co., Ltd.

Tel: 0755-84533301
Fax: NULL
Email: lxin@chipscreen.com
Country: China
ProdList: 2
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9126
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Artis Chemistry (Shanghai) Co. Ltd.

Tel: 86-21-60936353
Fax: 86-21-60936352
Country: China
ProdList: 335
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Zhengzhou HSH Science & Technology Co., Ltd.

Tel: 0371-55932928 18937192232
Fax: 0086-0371-55932928
Email: 1282296214@qq.com
Country: China
ProdList: 498
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

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View Lastest Price from Chidamide manufacturers

Dideu Industries Group Limited

Product: Chidamide 743420-02-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-17

Career Henan Chemical Co

Product: Chidamide 743420-02-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

743420-02-2, ChidamideRelated Search:

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(E)-N-(2-amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide Chidamide

Chidamide

(E)-N-(2-aMino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzaMide

N-(2-Amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propenyl]amino]methyl]benzamide

De-4-fluoro 5-Fluoro Chidamide

CHIDAMIDE;(E)-N-(2-AMINO-5-FLUOROPHENYL)-4-((3-(PYRIDIN-3-YL)ACRYLAMIDO)METHYL)BENZAMIDE;(E)-N-(2-AMINO-5-FLUOROPHENYL)-4-((3-(PYRIDIN-3-YL)ACRYLAMIDO)METHYL)BENZAMIDE CHIDAMIDE;N-(2-AMINO-5-FLUOROPHENYL)-4-[[[1-OXO-3-(3-PYRIDINYL)-2-PROPENYL]AMINO]METHYL

N-(2-Amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propenyl]amino]methyl

Chidamide D4

Tucidinostat (Chidamide)

chidamide analog

Chidamide(CS055

CS-1764

HBI-8000)

Chidamide,HBI-8000, CS-055, >96%

Chidamide impurity

HDAC-IN-7

Benzamide, N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-

Chidamide，HBI-8000， CS-055

Chidamide USP/EP/BP

N-(2-Amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide

Benzamide,N-(2-amino-5-fluorophenyl)-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]

N - (2-amino-5-fluorophenyl) -4- ((3- (pyridin-3-yl) acrylamide) methyl) benzamide

HDAC-IN-7, 10 mM in DMSO

N-(2-Amino-5-fluorophenyl)-4-(N-(3-pyridineacryloyl)aminomethyl)benzamide

743420-02-2

Inhibitors

API