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Mitoxantrone hydrochloride

Product Name
Mitoxantrone hydrochloride
CAS No.
70476-82-3
Chemical Name
Mitoxantrone hydrochloride
Synonyms
DHAQ;DHAD;IMMunex;cl232315;Novantron;Novatrone;novantrone;Bisantrone;NCI 301739;NSC-301739
CBNumber
CB4246424
Molecular Formula
C22H30Cl2N4O6
Formula Weight
517.4028
MOL File
70476-82-3.mol
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Mitoxantrone hydrochloride Property

Melting point:
203-205 C
storage temp. 
2-8°C
solubility 
Sparingly soluble in water, slightly soluble in methanol, practically insoluble in acetone.
form 
neat
Water Solubility 
Soluble to 5 mM in water and to 75 mM in DMSO
InChIKey
ZAHQPTJLOCWVPG-UHFFFAOYSA-N
CAS DataBase Reference
70476-82-3(CAS DataBase Reference)
EPA Substance Registry System
Mitoxantrone hydrochloride (70476-82-3)
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Safety

Hazard Codes 
T,T+
Risk Statements 
46-61-26/27/28
Safety Statements 
53-36/37/39-45-22
RIDADR 
3249
WGK Germany 
3
RTECS 
CB5748500
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29146100
Hazardous Substances Data
70476-82-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H310Fatal in contact with skin

H340May cause genetic defects

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M6545
Product name
Mitoxantrone dihydrochloride
Purity
≥97% (HPLC)
Packaging
10mg
Price
$52.2
Updated
2021/03/22
Sigma-Aldrich
Product number
M2305000
Product name
Mitoxantrone hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1445200
Product name
Mitoxantrone hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
400mg
Price
$1170
Updated
2021/03/22
TCI Chemical
Product number
M3110
Product name
Mitoxantrone Dihydrochloride
Packaging
100MG
Price
$67
Updated
2021/03/22
TCI Chemical
Product number
M3110
Product name
Mitoxantrone Dihydrochloride
Packaging
25MG
Price
$25
Updated
2021/03/22
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Mitoxantrone hydrochloride Chemical Properties,Usage,Production

Description

Mitoxantrone hydrochloride is the first of the synthetic anthracenediones related to doxorubicin to reach the marketplace. Mitoxantrone is useful in the treatment of advanced localized and metastatic mammary carcinomas. It is reported to be less cardiotoxic than doxorubicin.

Chemical Properties

Dark blue, electrostatic, hygroscopic powder.

Originator

Lederle (USA)

Uses

Mitoxanthrone hydrochloride USP (Novantrone) is used to traet acute nonlymphocytic leukemia, including myelogenous promyelocytic, monocytic, and erythroid acute leukemias.

Uses

analgesic, antipyretic

Manufacturing Process

A suspension of 12.5 g of 2-(2-aminoethylamino)ethanol in 40 ml of N,N,N',N'-tetramethylethylenediamine is stirred and de-aerated by bubbling nitrogen in for 15 min. A 10.97 g of leuco-1,4,5,8-tetrahydroxyanthraquinone is gradually added with stirring. The suspension is heated and stirred under nitrogen at 50-52°C for 5 hours. The mixture is allowed to stand and cool under nitrogen for 12 hours. The solid is collected by decantation, macerated in ethanol, collected and washed with ethanol giving 15.06 g of the desired product leuco-1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8- dihydroxyanthraquinone as a green-gray solid, melting point 129-131°C.
Chloranil oxidation. To 17.86 g of a suspension of the leuco-1,4-bis[2-(2- hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone (0.03 mole) in 2- methoxyethanol was added gradually with stirring 15 ml of 8 N ethanolic hydrogen chloride. The system was chilled with an ice bath and stirred as 7.50 g (0.0305 mole) of chloranil powder was gradually added. The mixture was stirred overnight at room temperature and diluted with 600 ml of ether. The solid was collected and washed with tetrahydrofuran. Yield of 1,4-bis[2-(2- hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone dihydrochloride 21.34 g, melting point 203-205°C (without recrystallisation).

brand name

Novantrone (Serono).

Therapeutic Function

Antineoplastic

General Description

Mitoxantrone is supplied as a blue aqueous solution in 10-and 20-mg vials for IV administration in the treatment of acute lymphoid leukemia, acute myeloid leukemia, breastcancer, prostate cancer, non-Hodgkin’s lymphoma, andmultiple sclerosis. The mechanisms of resistance are thesame as those seen for the anthracyclines. The distributionhalf-life is 1.1 to 3.1 hours, and the drug has a large volumeof distribution (11 L/kg). The elimination half-life rangedfrom 23 to 215 hours, and elimination was primarily via thebile. Metabolism of the agent involves oxidation of the sidechainalcohols to give the monocarboxylic and dicarboxylicacids.Other toxicities are those seen for the anthracyclinesand include myelosuppression, nausea, vomiting, mucositis,diarrhea, and alopecia. The intense color of the parent drugand metabolites may turn the urine blue.

Clinical Use

Mitoxantrone is used in combination with other agents during the initial treatment of acute nonlymphocytic leukemia and hormone-refractory prostate cancer. Recent studies have shown that mitoxantrone also decreases the rate of relapse and disease progression in patients with multiple sclerosis. Although too toxic for use in patients with primary progressive disease, it is available for the treatment of chronic progressive, progressive relapsing, or deteriorating relapsing-remitting multiple sclerosis.

Metabolism

Mitoxantrone excretion primarily is biliary. Both the unchanged drug and inactive metabolites resulting from N-dealkylation, deamination, and oxidation of the resultant aldehyde to the carboxylic acid are observed. Both arms of the structure can be metabolized, leading to mono- or dicarboxylic acid metabolites, which are excreted as the glucuronide conjugate. The conjugated metabolites are an intense, dark blue in color and will result in blue-green urine.

Mitoxantrone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Mitoxantrone hydrochloride Suppliers

Jinan Jason Pharmaceutical Co., Ltd.
Tel
0531-82956131 15069164249
Fax
0531-82956625
Email
jnjspharm@126.com
Country
China
ProdList
1525
Advantage
55
Beijing Xinze Pharmaceutical Technology Co., Ltd.
Tel
010-61393740
Email
weihong_1979@163.com
Country
CHINA
ProdList
49
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3579
Advantage
66
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5948
Advantage
61
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
Advantage
56
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35909
Advantage
56
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
Advantage
62
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19999
Advantage
64
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View Lastest Price from Mitoxantrone hydrochloride manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Mitoxantrone hydrochloride 70476-82-3
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
Mitoxantrone hydrochloride 70476-82-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Mitoxantrone hydrochloride 70476-82-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

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