Vincamine
- Product Name
- Vincamine
- CAS No.
- 1617-90-9
- Chemical Name
- Vincamine
- Synonyms
- Vinca;Vraap;Perval;Equipur;Minorin;Monorin;Novicet;Pervone;Oxybral;Angiopac
- CBNumber
- CB7344925
- Molecular Formula
- C21H26N2O3
- Formula Weight
- 354.44
- MOL File
- 1617-90-9.mol
Vincamine Property
- Melting point:
- 232 °C (dec.)(lit.)
- alpha
- 42.8 º (c=1 in pyridine)
- Boiling point:
- 487.66°C (rough estimate)
- Density
- 1.1640 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- pka
- 12.13±0.40(Predicted)
- form
- Solid
- color
- White to Off-White
- optical activity
- [α]23/D +42.8°, c = 1 in pyridine
- Merck
- 14,9983
- Stability:
- Hygroscopic
- LogP
- 3.100 (est)
- NIST Chemistry Reference
- Vincamine(1617-90-9)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 36-26
- WGK Germany
- 3
- RTECS
- YY8575000
- HS Code
- 29399990
- Hazardous Substances Data
- 1617-90-9(Hazardous Substances Data)
- Toxicity
- LD50 in mice (mg/kg): 75 i.v.; >1000 s.c. (Szporny, Szász); 1000 orally (Szabo, Nagy)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0002124
- Product name
- Vincamine
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0002124
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 75778
- Product name
- Vincamine
- Purity
- analytical standard
- Packaging
- 50mg
- Price
- $108
- Updated
- 2022/05/15
- Product number
- V0061
- Product name
- Vincamine
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $84
- Updated
- 2024/03/01
- Product number
- V0061
- Product name
- Vincamine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $281
- Updated
- 2024/03/01
- Product number
- J60545
- Product name
- Vincamine
- Purity
- 98%
- Packaging
- 1g
- Price
- $103
- Updated
- 2023/06/20
Vincamine Chemical Properties,Usage,Production
Chemical Properties
white to almost white fine crystalline powder
Originator
Pervancamine ,Dausse,France,1969
Uses
Vincamine is often used as a nootropic agent to combat the effects of aging, or in conjunction with other nootropics (such as piracetam) for a variety of purposes. Vincamine is a peripheral vasodilator that increases blood flow to the brain.
Definition
ChEBI: Vincamine is a vinca alkaloid, an alkaloid ester, an organic heteropentacyclic compound, a methyl ester and a hemiaminal. It has a role as an antihypertensive agent, a vasodilator agent and a metabolite. It is functionally related to an eburnamenine.
Manufacturing Process
The following route is described in US Patent 4,145,552: At ambient temperature, over a period of thirty minutes, a solution of 33.8g (0.1mol) of (-)-vincadiformine in a mixture of 140 ml of anhydrous dimethylformamide and 140 ml of anhydrous toluene is added to a suspension of 2.64 g (0.11 mol) of sodium hydride in a mixture of 200 ml of anhydrous tetrahydrofuran, 20 ml of anhydrous hexamethylphosphotriamide (EMPT) and 18.7 ml (0.14 mol) of trimethyl phosphite. When the release of hydrogen has finished (about two hours later), the solution is cooled to -10°C and then stirred under an oxygen atmosphere until absorption ceases (duration: 3 hours). Still at -10°C, 136 ml of glacial acetic acid are added, and the mixture is then left at ambient temperature for two hours. After the addition of 500 ml of 1 N sulfuric acid, the aqueous phase is isolated, reextracted with 150 ml of isopropyl ether, made alkaline with 350 ml of 11 N ammonia, then extracted 3 times with 300 ml aliquots of methylene chloride. After drying over calcium chloride and evaporating the solvent, 30.2 g of crude product are obtained which, when chromatographed on a column of silica gel (1.5 kg) yield, 9.9 g of vincamine (yield: 28%) melting point (decomp.): 250°C.
brand name
Cerebroxine;Cetal;Ocu-vinc;Oxygeron;Pervincamine;Vadicate;Vinca minor;Vincacen;Vincapront;Vincavix;Vincimax.
Therapeutic Function
Vasodilator
World Health Organization (WHO)
Vincamine, an alkaloid derived from Vinca minor, is claimed to increase cerebral circulation and utilization of oxygen. It is used in a variety of cerebral disorders and is widely marketed for this purpose.
General Description
Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor L., belonging to the Apocynaceae family.
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View Lastest Price from Vincamine manufacturers
- Product
- Vincamine 1617-90-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2022-11-02
- Product
- Vincamine 1617-90-9
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 98.5%-101.5%
- Supply Ability
- 100kg
- Release date
- 2021-09-15
- Product
- Vincamine 1617-90-9
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-08-24