VERBENALIN

Product Name: VERBENALIN
CAS No.: 548-37-8
Chemical Name: VERBENALIN
Synonyms: CORNIN;VERBENALIN;Verbenalinp;Verbenaline;VERBENALOSIDE;Verbenalin-RM;Verbenalin CRS;cornin(glycoside;cornin(glycoside);CORNIN (VERBENALIN)
CBNumber: CB1275900
Molecular Formula: C17H24O10
Formula Weight: 388.37
MOL File: 548-37-8.mol

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VERBENALIN Property

Melting point:: 180-182°C
alpha: D25 -173° (water)
Boiling point:: 610.1±55.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO : 250 mg/mL (643.72 mM; Need ultrasonic)
pka: 12.79±0.70(Predicted)
form: powder
color: White
Merck: 13,10021
BRN: 57895
InChIKey: HLXRWTJXGMHOFN-XJSNKYLASA-N
SMILES: [C@@]12([H])[C@@H](C)CC(=O)[C@]1([H])C(C(=O)OC)=CO[C@H]2O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O |&1:0,2,7,16,18,19,21,22,24,r|
LogP: -2.390 (est)
CAS DataBase Reference: 548-37-8

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: GY5826000
F: 10-21

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000661
Product name: Verbenalin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 11 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000661
Product name: Verbenalin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000661
Price: $151
Updated: 2023/06/20

Sigma-Aldrich

Product number: SMB00398
Product name: Verbenalin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $107
Updated: 2023/06/20

TRC

Product number: V128005
Product name: Verbenalin
Packaging: 10mg
Price: $120
Updated: 2021/12/16

TRC

Product number: V128005
Product name: Verbenalin
Packaging: 50mg
Price: $455
Updated: 2021/12/16

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VERBENALIN Chemical Properties,Usage,Production

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from verbena and euphorbia.

Uses

Verbenalin is an iridoid glucoside isolated found in Verbena officinalis and other herb plants.

Uses

cell growth inhibitor, coagulant

Definition

ChEBI: Verbenalin is a terpene glycoside.

Biological Activity

Cornin is used in cardiology due to its cardioprotective property. It helps to lower blood pressure, improve heart activity, and reverse cardiac hypertrophy It can prevent lipid peroxidation catalyzed by Fe2+. Cornin can also prevent the activities of cyclooxygenase 1 (COX-1) and cyclooxygenase 1 (COX-2) enzymes. It plays a protective role against cerebral ischemia injury.

in vivo

Verbenalin (100-200 mg/kg; gavage; 35 days) reduces the levels of Aβ and tau in the hippocampus and restores the expression of BDNF in the AD mouse model^[1].
Verbenalin (50-200 mg/kg; gavage; 21 days) has an improving effect in the mouse prostatitis model^[2].
Verbenalin (5-20 mg/kg; intravenous injection; single dose) has a protective effect in the rat model of focal cerebral ischemia-reperfusion^[3].
Verbenalin (12.5-50 mg/kg; gavage; 16 days) can alleviate liver injury, regulate lipid homeostasis, inhibit oxidative stress-induced ferroptosis, and improve mitochondrial function in the mouse model of alcoholic steatohepatitis^[5].

Animal Model:	KM male mice (24-26 g) treated Xiaozhiling to induce prostatitis model^[2]
Dosage:	50, 100 and 200 mg/kg
Administration:	Oral gavage (i.g.); 21 days
Result:	Had significantly increased amounts of water, and prostate white blood cell count and prostate volume density were decreased significantly, the density of lecithin corpuscle score increased, and pathologic prostatitis changes were significantly reduced. Significantly reduced pathological change in the testis and the change in the epididymis. Increased significantly the thymic cortex thickness and the number of lymphocytes. Reduce the renal pathological changes in potential.

Animal Model:	Male KM rats (25-30 g) with focal cerebral ischemia reperfusion^[3]
Dosage:	5, 10 and 20 mg/kg
Administration:	Intravenous injection (i.v.); single dose
Result:	Significantly reduced the mortality rate, neurological deficit score and the percentage of cerebral infarction size. Significantly reduced the levels of Bax, Caspase-3, S-100β level of the serum in the brain tissue. Increased the levels of Bcl-2 and ATPase in brain tissue and improved pathological damage of hippocampus and cortex. Inhibited the expression of apoptosis genes, promoted the expression of anti-apoptosis genes, improved brain microcirculation and energy metabolism, hence reducing cerebral ischemia-reperfusion injury.

VERBENALIN Preparation Products And Raw materials

Raw materials

Preparation Products

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VERBENALIN Suppliers

China 190 France 2 Germany 3 India 1 Switzerland 1 United Kingdom 5 United States 21 USA 1 Global 224

Chengdu PFID reference Technology Co., Ltd

Tel: 028-82610909 15882229804
Email: pufeide@foxmail.com
Country: China
ProdList: 2335
Advantage: 58

Shanghai Standard Technology Co.,Ltd.

Tel: 021-021-57127007-6622-6622 17621252073
Fax: +86 (21) 5132-0077
Email: luzh@nature-standard.com
Country: China
ProdList: 3021
Advantage: 58

Huzhou ZhanShu Biotechnology Co.,Ltd

Tel: 0572-8889530 18167260939
Email: zsubio@163.com
Country: China
ProdList: 392
Advantage: 58

Jiangsu Yongjian Pharmaceutical Technology Co., Ltd

Tel: 17701422015
Email: 3582572959@qq.com
Country: China
ProdList: 979
Advantage: 58

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 021-38218169 13341702378
Fax: QQ：190129269
Email: winherb@126.com
Country: China
ProdList: 1245
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

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View Lastest Price from VERBENALIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Verbenalin 548-37-8
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-24

Career Henan Chemical Co

Product: VERBENALIN 548-37-8
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

548-37-8, VERBENALINRelated Search:

Vincristine Vetivert oil Verbena Oil Vincamine VINBLASTINE VERAPAMIL IMPURITY M VERAPAMIL IMPURITY I 3-ETHOXYACRYLIC ACID Cyclopentanemethanol 3,4-DIHYDRO-2-METHOXY-2H-PYRAN Levulinic acid 2-ETHOXY-3,4-DIHYDRO-2H-PYRAN isobutoxypropanol 2-OXO-CYCLOPENTANEACETIC ACID 3,4-Dihydro-2H-pyran VERBENALIN Methyl 3-methoxyacrylate Methyl allyl ketone

cyclopenta(c)pyran-4-carboxylicacid,1,4a,5,6,7,7a-hexahydro-1-(beta-d-glucopy

ranosyloxy)-7-methyl-5-oxo-,methylester,(1s-(1-alpha,4a-alpha,7-alapha,7a-a

Verbenaline

Methyl (1S,4aS,7S,7aR)-7-Methyl-5-oxo-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate

Verbenalinp

VERBENALIN

VERBENALOSIDE

cornin(glycoside

cornin(glycoside)

Verbenalin, 98%, from Verbena officinalis L.

CORNIN

(4aS,7S,7aR)-7-methyl-5-oxo-1-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-4a,6,7,7a-tetrahydro-1H-cyclopenta[c]pyran-4-carboxylic acid methyl ester

Verbenalin CRS

Verbenalol glucoside

Verbenalol β-D-glucopyranoside

Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-7-methyl-5-oxo-, methyl ester, (1S,4aS,7S,7aR)-

methyl (1S,4aS,7S,7aR)-7-methyl-5-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4a,6,7,7a-tetrahydro-1H-cyclopenta[c]pyran-4-carboxylate

CORNIN (VERBENALIN)

Methyl (1S,4aS,7S,7aR)-7-methyl-5-oxo-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate

Verbenalin-RM

Verbenalin, 10 mM in DMSO

548-37-8

Iridoids

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

chemical reagent

pharmaceutical intermediate