ChemicalBook > CAS DataBase List > VERBENALIN

VERBENALIN

Product Name: VERBENALIN
CAS No.: 548-37-8
Chemical Name: VERBENALIN
Synonyms: CORNIN;VERBENALIN;Verbenalinp;Verbenaline;VERBENALOSIDE;Verbenalin-RM;Verbenalin CRS;cornin(glycoside;cornin(glycoside);CORNIN (VERBENALIN)
CBNumber: CB1275900
Molecular Formula: C17H24O10
Formula Weight: 388.37
MOL File: 548-37-8.mol

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VERBENALIN Property

Melting point:: 180-182°C
alpha: D25 -173° (water)
Boiling point:: 610.1±55.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO : 250 mg/mL (643.72 mM; Need ultrasonic)
pka: 12.79±0.70(Predicted)
form: powder
color: White
Merck: 13,10021
BRN: 57895
InChIKey: HLXRWTJXGMHOFN-XJSNKYLASA-N
SMILES: [C@@]12([H])[C@@H](C)CC(=O)[C@]1([H])C(C(=O)OC)=CO[C@H]2O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O |&1:0,2,7,16,18,19,21,22,24,r|
LogP: -2.390 (est)
CAS DataBase Reference: 548-37-8

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: GY5826000
F: 10-21

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000661
Product name: Verbenalin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 11 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000661
Product name: Verbenalin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000661
Price: $151
Updated: 2023/06/20

Sigma-Aldrich

Product number: SMB00398
Product name: Verbenalin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $107
Updated: 2023/06/20

TRC

Product number: V128005
Product name: Verbenalin
Packaging: 10mg
Price: $120
Updated: 2021/12/16

TRC

Product number: V128005
Product name: Verbenalin
Packaging: 50mg
Price: $455
Updated: 2021/12/16

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VERBENALIN Chemical Properties,Usage,Production

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from verbena and euphorbia.

Uses

Verbenalin is an iridoid glucoside isolated found in Verbena officinalis and other herb plants.

Uses

cell growth inhibitor, coagulant

Definition

ChEBI: Verbenalin is a terpene glycoside.

Biological Activity

Cornin is used in cardiology due to its cardioprotective property. It helps to lower blood pressure, improve heart activity, and reverse cardiac hypertrophy It can prevent lipid peroxidation catalyzed by Fe2+. Cornin can also prevent the activities of cyclooxygenase 1 (COX-1) and cyclooxygenase 1 (COX-2) enzymes. It plays a protective role against cerebral ischemia injury.

in vivo

Verbenalin (100-200 mg/kg; gavage; 35 days) reduces the levels of Aβ and tau in the hippocampus and restores the expression of BDNF in the AD mouse model^[1].
Verbenalin (50-200 mg/kg; gavage; 21 days) has an improving effect in the mouse prostatitis model^[2].
Verbenalin (5-20 mg/kg; intravenous injection; single dose) has a protective effect in the rat model of focal cerebral ischemia-reperfusion^[3].
Verbenalin (12.5-50 mg/kg; gavage; 16 days) can alleviate liver injury, regulate lipid homeostasis, inhibit oxidative stress-induced ferroptosis, and improve mitochondrial function in the mouse model of alcoholic steatohepatitis^[5].

Animal Model:	KM male mice (24-26 g) treated Xiaozhiling to induce prostatitis model^[2]
Dosage:	50, 100 and 200 mg/kg
Administration:	Oral gavage (i.g.); 21 days
Result:	Had significantly increased amounts of water, and prostate white blood cell count and prostate volume density were decreased significantly, the density of lecithin corpuscle score increased, and pathologic prostatitis changes were significantly reduced. Significantly reduced pathological change in the testis and the change in the epididymis. Increased significantly the thymic cortex thickness and the number of lymphocytes. Reduce the renal pathological changes in potential.

Animal Model:	Male KM rats (25-30 g) with focal cerebral ischemia reperfusion^[3]
Dosage:	5, 10 and 20 mg/kg
Administration:	Intravenous injection (i.v.); single dose
Result:	Significantly reduced the mortality rate, neurological deficit score and the percentage of cerebral infarction size. Significantly reduced the levels of Bax, Caspase-3, S-100β level of the serum in the brain tissue. Increased the levels of Bcl-2 and ATPase in brain tissue and improved pathological damage of hippocampus and cortex. Inhibited the expression of apoptosis genes, promoted the expression of anti-apoptosis genes, improved brain microcirculation and energy metabolism, hence reducing cerebral ischemia-reperfusion injury.

VERBENALIN Preparation Products And Raw materials

Raw materials

Preparation Products

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VERBENALIN Suppliers

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View Lastest Price from VERBENALIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Verbenalin 548-37-8
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-24

Career Henan Chemical Co

Product: VERBENALIN 548-37-8
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

548-37-8, VERBENALINRelated Search:

Vincristine Vetivert oil Verbena Oil Vincamine VINBLASTINE VERAPAMIL IMPURITY M VERAPAMIL IMPURITY I 3-ETHOXYACRYLIC ACID Cyclopentanemethanol 3,4-DIHYDRO-2-METHOXY-2H-PYRAN Levulinic acid 2-ETHOXY-3,4-DIHYDRO-2H-PYRAN isobutoxypropanol 2-OXO-CYCLOPENTANEACETIC ACID 3,4-Dihydro-2H-pyran VERBENALIN Methyl 3-methoxyacrylate Methyl allyl ketone

cyclopenta(c)pyran-4-carboxylicacid,1,4a,5,6,7,7a-hexahydro-1-(beta-d-glucopy

ranosyloxy)-7-methyl-5-oxo-,methylester,(1s-(1-alpha,4a-alpha,7-alapha,7a-a

Verbenaline

Methyl (1S,4aS,7S,7aR)-7-Methyl-5-oxo-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate

Verbenalinp

VERBENALIN

VERBENALOSIDE

cornin(glycoside

cornin(glycoside)

Verbenalin, 98%, from Verbena officinalis L.

CORNIN

(4aS,7S,7aR)-7-methyl-5-oxo-1-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-4a,6,7,7a-tetrahydro-1H-cyclopenta[c]pyran-4-carboxylic acid methyl ester

Verbenalin CRS

Verbenalol glucoside

Verbenalol β-D-glucopyranoside

Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-7-methyl-5-oxo-, methyl ester, (1S,4aS,7S,7aR)-

methyl (1S,4aS,7S,7aR)-7-methyl-5-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4a,6,7,7a-tetrahydro-1H-cyclopenta[c]pyran-4-carboxylate

CORNIN (VERBENALIN)

Methyl (1S,4aS,7S,7aR)-7-methyl-5-oxo-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate

Verbenalin-RM

Verbenalin, 10 mM in DMSO

548-37-8

Iridoids

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

chemical reagent

pharmaceutical intermediate