ChemicalBook > CAS DataBase List > SB242235

SB242235

Product Name
SB242235
CAS No.
193746-75-7
Chemical Name
SB242235
Synonyms
CS-668;SB242235;SB242235 ≥95%;SB-242235; SB242235;inhibit,SB 242235,Autophagy,Inhibitor,p38 MAPK;4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine;4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-iMidazol-5-yl)-2-MethoxypyriMidine;Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-
CBNumber
CB12621150
Molecular Formula
C19H20FN5O
Formula Weight
353.39
MOL File
193746-75-7.mol
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SB242235 Property

Boiling point:
568.4±60.0 °C(Predicted)
Density 
1.34
storage temp. 
2-8°C(protect from light)
solubility 
DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml
form 
Powder
pka
9.91±0.10(Predicted)
color 
White to off-white
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Safety

HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
474182
Product name
SB 242235
Packaging
100mg
Price
$1848
Updated
2021/12/16
Biorbyt Ltd
Product number
orb180841
Product name
SB242235
Purity
>98%
Packaging
1000mg
Price
$2395.3
Updated
2021/12/16
Matrix Scientific
Product number
132624
Product name
4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Purity
97%
Packaging
5g
Price
$3960
Updated
2021/12/16
AK Scientific
Product number
3254AH
Product name
4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Packaging
5g
Price
$5396
Updated
2021/12/16
Matrix Scientific
Product number
132624
Product name
4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Purity
97%
Packaging
10g
Price
$6480
Updated
2021/12/16
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SB242235 Chemical Properties,Usage,Production

Biological Activity

SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM in human chondrocytes.

in vitro

SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC 50 of 1.0 μM in human chondrocytes stimulated with IL-1β.
SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.

Western Blot Analysis

< td class="col2"> 15 minutes
Cell Line: Human chondrocytes
Concentration: 0 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM
Incubation Time:
Result: Dose-dependently inhibited the activation of MAPKAP K2 with an IC 50 of 1.0 μM.

target

IC50: 1.0 μM (p38 MAPK, primary human chondrocytes)

SB242235 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB242235 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
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2922
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55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
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China
ProdList
7552
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61
SYN|thesis med chem P/L
Tel
+86-021-50720296
Fax
+86-021-50720297
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service@synkinase.com
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China
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266
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ShangHai YingYi Chemical Technology Co., Ltd.
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86-21-50700185 13764109623
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86-21-50700185
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sale@inyelchem.com
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China
ProdList
178
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
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025-68650336
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info@adooq.cn
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China
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2990
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LETOPHARM LIMITED
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+86-21-5821 5861
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+86-21-5106 2861
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sales@letopharm.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696,15000506266 15000506266
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+86-21-52996696
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China
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SPIRO PHARMA
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eric_feng1954@126.com
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China
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Hangzhou ChangCun Biotechnology Co., Ltd.
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0571-; 13567100326
Fax
QQ158848739
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158848739@qq.com
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China
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50
Pharmacodia (Beijing) Co.,Ltd
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+86-400-851-9921
Fax
+86-10-82826195
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sales@pharmacodia.com
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China
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2317
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193746-75-7, SB242235Related Search:


  • SB-242235; SB242235
  • CS-668
  • SB242235
  • 4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine
  • 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-iMidazol-5-yl)-2-MethoxypyriMidine
  • SB242235 ≥95%
  • Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-
  • inhibit,SB 242235,Autophagy,Inhibitor,p38 MAPK
  • 193746-75-7