SB242235

ChemicalBook > CAS DataBase List > SB242235

Product Name: SB242235
CAS No.: 193746-75-7
Chemical Name: SB242235
Synonyms: CS-668;SB242235;SB242235 ≥95%;SB-242235; SB242235;inhibit,SB 242235,Autophagy,Inhibitor,p38 MAPK;4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine;4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-iMidazol-5-yl)-2-MethoxypyriMidine;Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-
CBNumber: CB12621150
Molecular Formula: C19H20FN5O
Formula Weight: 353.39
MOL File: 193746-75-7.mol

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SB242235 Property

Boiling point:: 568.4±60.0 °C(Predicted)
Density: 1.34
storage temp.: 2-8°C(protect from light)
solubility: DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml
form: Powder
pka: 9.91±0.10(Predicted)

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 474182
Product name: SB 242235
Packaging: 100mg
Price: $1848
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180841
Product name: SB242235
Purity: >98%
Packaging: 1000mg
Price: $2395.3
Updated: 2021/12/16

Matrix Scientific

Product number: 132624
Product name: 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Purity: 97%
Packaging: 5g
Price: $3960
Updated: 2021/12/16

AK Scientific

Product number: 3254AH
Product name: 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Packaging: 5g
Price: $5396
Updated: 2021/12/16

Matrix Scientific

Product number: 132624
Product name: 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Purity: 97%
Packaging: 10g
Price: $6480
Updated: 2021/12/16

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SB242235 Chemical Properties,Usage,Production

Biological Activity

SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM in human chondrocytes.

in vitro

SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC ₅₀ of 1.0 μM in human chondrocytes stimulated with IL-1β.
SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.

Western Blot Analysis

< td class="col2"> 15 minutes

Cell Line:	Human chondrocytes
Concentration:	0 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM
Incubation Time:
Result:	Dose-dependently inhibited the activation of MAPKAP K2 with an IC ₅₀ of 1.0 μM.

target

IC50: 1.0 μM (p38 MAPK, primary human chondrocytes)

SB242235 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB242235 Suppliers

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193746-75-7, SB242235Related Search:

SB 743921 Pracinostat SB 225002 SB216763 Sb-742457 MMP-2/MMP-9 INHIBITOR IV SB 242084 (hydrochloride) SB 415286 SB 202190 SB 431542 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 269970 HYDROCHLORIDE SB1317 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 4'-CHLORO-3-METHOXYCINNAMANILIDE SB-705498 SB 203580 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

SB-242235; SB242235

CS-668

SB242235

4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine

4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-iMidazol-5-yl)-2-MethoxypyriMidine

SB242235 ≥95%

Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-

inhibit,SB 242235,Autophagy,Inhibitor,p38 MAPK

193746-75-7