ChemicalBook > CAS DataBase List > SB242235

SB242235

Product Name: SB242235
CAS No.: 193746-75-7
Chemical Name: SB242235
Synonyms: CS-668;SB242235;SB242235 ≥95%;SB-242235; SB242235;SB 242235, 10 mM in DMSO;inhibit,SB 242235,Autophagy,Inhibitor,p38 MAPK;4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine;4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-iMidazol-5-yl)-2-MethoxypyriMidine;Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-
CBNumber: CB12621150
Molecular Formula: C19H20FN5O
Formula Weight: 353.39
MOL File: 193746-75-7.mol

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SB242235 Property

Boiling point:: 568.4±60.0 °C(Predicted)
Density: 1.34
storage temp.: 2-8°C(protect from light)
solubility: DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml
form: Powder
pka: 9.91±0.10(Predicted)
color: White to off-white

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 474182
Product name: SB 242235
Packaging: 100mg
Price: $1848
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180841
Product name: SB242235
Purity: >98%
Packaging: 1000mg
Price: $2395.3
Updated: 2021/12/16

Matrix Scientific

Product number: 132624
Product name: 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Purity: 97%
Packaging: 5g
Price: $3960
Updated: 2021/12/16

AK Scientific

Product number: 3254AH
Product name: 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Packaging: 5g
Price: $5396
Updated: 2021/12/16

Matrix Scientific

Product number: 132624
Product name: 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Purity: 97%
Packaging: 10g
Price: $6480
Updated: 2021/12/16

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SB242235 Chemical Properties,Usage,Production

Uses

SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC50 of 1.0　μM in primary human chondrocytes[1].

Biological Activity

SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM in human chondrocytes.

in vitro

SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC ₅₀ of 1.0 μM in human chondrocytes stimulated with IL-1β.
SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.

Western Blot Analysis

< td class="col2"> 15 minutes

Cell Line:	Human chondrocytes
Concentration:	0 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM
Incubation Time:
Result:	Dose-dependently inhibited the activation of MAPKAP K2 with an IC ₅₀ of 1.0 μM.

in vivo

SB242235 (100 mg/kg; p.o.) abolishes MAP-KAPK-2 activity and HSP27 phosphorylation^[2].
SB242235 inhibits expression of the pro-inflammatory cytokines interleukin (IL)-6 and KC (murine IL-8) and COX-2^[2].
SB-242235 is demonstrated non-linear elimination kinetics that manifested as a decrease in clearance with increasing dose and apparent oral bioavailability > 100% at high oral doses in rat and monkey^[3].

Animal Model:	Female SKH-1 hairless mice (4–6 weeks)^[2]
Dosage:	100 mg/kg
Administration:	Oral administered, 30 minutes prior to ultraviolet B (UVB) irradiation
Result:	Abolished MAP-KAPK-2 activity and heat shock protein 27 (HSP27) phosphorylation.

target

IC50: 1.0 μM (p38 MAPK, primary human chondrocytes)

References

[1] Badger, A.M., et al., Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures. Osteoarthritis Cartilage, 2000. 8(6): p. 434-43. DOI:10.1053/joca.1999.0319
[2] Kim AL , et al. Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J Invest Dermatol. 2005 Jun;124(6):1318-25. DOI:10.1111/j.0022-202X.2005.23747.x
[3] Ward, K.W., et al., SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics. Xenobiotica, 2002. 32(3): p. 221-33. DOI:10.1080/00498250110100720

SB242235 Preparation Products And Raw materials

Raw materials

Preparation Products

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193746-75-7, SB242235Related Search:

SB 743921 Pracinostat SB 225002 SB216763 Sb-742457 MMP-2/MMP-9 INHIBITOR IV SB 242084 (hydrochloride) SB 415286 SB 202190 SB 431542 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 269970 HYDROCHLORIDE SB1317 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 4'-CHLORO-3-METHOXYCINNAMANILIDE SB-705498 SB 203580 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

SB-242235; SB242235

CS-668

SB242235

4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine

4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-iMidazol-5-yl)-2-MethoxypyriMidine

SB242235 ≥95%

Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-

inhibit,SB 242235,Autophagy,Inhibitor,p38 MAPK

SB 242235, 10 mM in DMSO

193746-75-7