Saracatinib
- Product Name
- Saracatinib
- CAS No.
- 379231-04-6
- Chemical Name
- Saracatinib
- Synonyms
- CS-69;EOS-61866;saracatinib;Gemcabene Calcium;Saracatinib, >=98%;AZD0530 difuMarate;AZD0530(Saracatinib);Saracatinib (AZD0530);Saracatinib USP/EP/BP;TIANFUCHEM-- Saracatinib
- CBNumber
- CB61518531
- Molecular Formula
- C27H32ClN5O5
- Formula Weight
- 542.03
- MOL File
- 379231-04-6.mol
Saracatinib Property
- Melting point:
- 84-89°C
- Boiling point:
- 671.2±55.0 °C(Predicted)
- Density
- 1.348
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (50 mg/ml) and ethanol (54 mg/mL with warming)
- pka
- 7.55±0.10(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 11497
- Product name
- Saracatinib
- Purity
- ≥90%
- Packaging
- 5mg
- Price
- $31
- Updated
- 2024/03/01
- Product number
- 11497
- Product name
- Saracatinib
- Purity
- ≥90%
- Packaging
- 10mg
- Price
- $53
- Updated
- 2024/03/01
- Product number
- 11497
- Product name
- Saracatinib
- Purity
- ≥90%
- Packaging
- 25mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- 11497
- Product name
- Saracatinib
- Purity
- ≥90%
- Packaging
- 50mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 7189
- Product name
- Saracatinib
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $125
- Updated
- 2021/12/16
Saracatinib Chemical Properties,Usage,Production
Description
Saracatinib is a dual inhibitor of the tyrosine kinases c-
Chemical Properties
White Solid
Uses
An oral, selective dual inhibitor of Src and ABL kinase. It is a COVID19-related research product.
Definition
ChEBI: Saracatinib is a member of the class of quinazolines that is quinazoline substituted by (5-chloro-2H-1,3-benzodioxol-4-yl)amino, (oxan-4-yl)oxy and 2-(4-methylpiperazin-1-yl)ethoxy groups at positions 4, 5 and 7, respectively. It is a dual inhibitor of the tyrosine kinases c-Src and Abl (IC50 = 2.7 and 30 nM, respectively). Saracatinib was originally developed by AstraZeneca for the treatment of cancer but in 2019 it was granted orphan drug designation by the US Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis (IPF), a type of lung disease that results in scarring (fibrosis) of the lungs. It has a role as an antineoplastic agent, an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, a radiosensitizing agent, an autophagy inducer, an apoptosis inducer and an anticoronaviral agent. It is a member of quinazolines, a secondary amino compound, a N-methylpiperazine, an aromatic ether, a member of oxanes, a member of benzodioxoles, an organochlorine compound and a diether.
storage
Store at -20°C
References
Hennequin et al. (2006), N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor; J. Med. Chem., 49 6465 Green et al. (2009), Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530; Oncol., 3 248 de Wispelaere et al. (2013), The small molecules AZD0530 and Dasatinib inhibit dengue virus RNA replication via Fyn kinase; Virol., 87 7367 Shin et al. (2018), Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro; Viruses, 10 283 Tang et al. (2020), Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic mice and traumatic Tauopathy; Acta Neuropathol. Commun., 8 96 Kaufman et al. (2015), Fyn inhibition rescues established memory and synapse loss in Alzheimer mice; Neurol., 77 953
Saracatinib Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Saracatinib manufacturers
- Product
- Saracatinib 379231-04-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20ton
- Release date
- 2020-10-28
- Product
- Saracatinib 379231-04-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-05