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Dasatinib monohydrate

Product Name
Dasatinib monohydrate
CAS No.
863127-77-9
Chemical Name
Dasatinib monohydrate
Synonyms
Sprycel;Dasatinib hydrate;mmbf;CS-295;Dastinib;Dasatinib R;Bms 35482503;Unii-rbz1571X5h;Dasatinib(TINIBS);Dasatinib(Sprycel)
CBNumber
CB4844484
Molecular Formula
C22H28ClN7O3S
Formula Weight
506.02
MOL File
863127-77-9.mol
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Dasatinib monohydrate Property

Melting point:
>223° (dec.)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
InChIKey
XHXFZZNHDVTMLI-UHFFFAOYSA-N
SMILES
N(C1=NC=C(C(=O)NC2C(=CC=CC=2C)Cl)S1)C1N=C(C)N=C(N2CCN(CCO)CC2)C=1.O
CAS DataBase Reference
863127-77-9(CAS DataBase Reference)
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H360May damage fertility or the unborn child

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D193638
Product name
DasatinibMonohydrate
Packaging
250mg
Price
$50
Updated
2021/12/16
TRC
Product number
D193638
Product name
DasatinibMonohydrate
Packaging
500mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD10821
Product name
Dasatinib monohydrate
Packaging
500mg
Price
$80
Updated
2021/12/16
ApexBio Technology
Product number
B5954
Product name
DasatinibMonohydrate
Packaging
500mg
Price
$95
Updated
2021/12/16
AK Scientific
Product number
J11235
Product name
Dasatinibmonohydrate
Packaging
25mg
Price
$49
Updated
2021/12/16
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Dasatinib monohydrate Chemical Properties,Usage,Production

Uses

antineoplastic

Uses

Dasatinib Monohydrate is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. It is a COVID19-related research product.

Definition

ChEBI: A hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhyd ous dasatinib (INN).

brand name

Sprycel (Bristol-Myers Squibb).

Biological Activity

chronic myeloid leukemia (cml) is a disease characterized by the presence of the philadelphia (ph+) chromosome and its oncogenic product, bcr-abl, that is present in >90% of the patients. dasatinib (bms-354825) is a novel, potent, and multitargeted kinase inhibitor that targets abl, src, kit, pdgfr, and other tyrosine kinases.

in vitro

dasatinib is a potent atp-competitive inhibitor in biochemical assays with broad-spectrum antiproliferative activities against hematological and solid tumor cell lines. dasatinib was more potent than imatinib at inhibiting nonmutated bcr-abl kinase activity. in addition, the kinase activity of 14 out of 15 different clinically relevant, imatinib-resistant bcr-abl isoforms was successfully inhibited [1].

in vivo

mice were dosed with dasatinib or vehicle alone by gavage for 2 weeks, beginning 3 days after injection of ba/f3 cells. all vehicle-treated mice developed progressive disease. in contrast, dasatinib–treated mice harboring nonmutant bcr-abl or the clinically common imatinib-resistant mutation m351t appeared healthy with no evidence of weight loss, lethargy, or ruffled fur and showed more than one log lower levels of bioluminescent activity after 2 weeks of therapy [2].

IC 50

0.55 and 3.0 nm for src and bcr-abl tyrosine kinases, respectively

References

[1] shah np, tran c, lee fy, chen p, norris d, sawyers cl. overriding imatinib resistance with a novel abl kinase inhibitor. science. 2004 jul 16;305(5682):399-401.
[2] monika conchon, carla maria boquimpani de moura freitas, maria aparecida do carmo rego, and josé wilson ramos braga junior. dasatinib -

Dasatinib monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Dasatinib monohydrate Suppliers

Nanjing EnMing Pharmaceutical Technology Co., Ltd.
Tel
025-58894663 13305188663
Fax
025-58894661
Email
njempt@163.com
Country
China
ProdList
19
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4698
Advantage
58
Sichuan Mingjian Pharmaceutical Chemical Co., Ltd.
Tel
15281098982
Email
sales@mjpharma.cn
Country
China
ProdList
108
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
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View Lastest Price from Dasatinib monohydrate manufacturers

Wuhan Xinhao Biotechnology Co., Ltd
Product
Dasatinib monohydrate 863127-77-9
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2024-03-11
shandong perfect biotechnology co.ltd
Product
Dasatinib 863127-77-9
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1kg
Release date
2023-08-02
Nanjing Fred Technology Co., Ltd
Product
Dasatinib monohydrate 863127-77-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%, Single impurity<0.1
Supply Ability
1 ton
Release date
2023-12-20

863127-77-9, Dasatinib monohydrateRelated Search:


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