Dasatinib monohydrate
- Product Name
- Dasatinib monohydrate
- CAS No.
- 863127-77-9
- Chemical Name
- Dasatinib monohydrate
- Synonyms
- Sprycel;Dasatinib hydrate;mmbf;CS-295;Dastinib;Dasatinib R;Bms 35482503;Unii-rbz1571X5h;Dasatinib(TINIBS);Dasatinib(Sprycel)
- CBNumber
- CB4844484
- Molecular Formula
- C22H28ClN7O3S
- Formula Weight
- 506.02
- MOL File
- 863127-77-9.mol
Dasatinib monohydrate Property
- Melting point:
- >223° (dec.)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChIKey
- XHXFZZNHDVTMLI-UHFFFAOYSA-N
- SMILES
- N(C1=NC=C(C(=O)NC2C(=CC=CC=2C)Cl)S1)C1N=C(C)N=C(N2CCN(CCO)CC2)C=1.O
- CAS DataBase Reference
- 863127-77-9(CAS DataBase Reference)
Safety
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P281Use personal protective equipment as required.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D193638
- Product name
- DasatinibMonohydrate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- D193638
- Product name
- DasatinibMonohydrate
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD10821
- Product name
- Dasatinib monohydrate
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- B5954
- Product name
- DasatinibMonohydrate
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- J11235
- Product name
- Dasatinibmonohydrate
- Packaging
- 25mg
- Price
- $49
- Updated
- 2021/12/16
Dasatinib monohydrate Chemical Properties,Usage,Production
Uses
antineoplastic
Uses
Dasatinib Monohydrate is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. It is a COVID19-related research product.
Definition
Dasatinib monohydrate is a hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN； dasatinib monohydrate) as well as to anhydrous dasatinib (INN). It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It contains a dasatinib (anhydrous).
brand name
Sprycel (Bristol-Myers Squibb).
Biological Activity
chronic myeloid leukemia (cml) is a disease characterized by the presence of the philadelphia (ph+) chromosome and its oncogenic product, bcr-abl, that is present in >90% of the patients. dasatinib (bms-354825) is a novel, potent, and multitargeted kinase inhibitor that targets abl, src, kit, pdgfr, and other tyrosine kinases.
in vitro
dasatinib is a potent atp-competitive inhibitor in biochemical assays with broad-spectrum antiproliferative activities against hematological and solid tumor cell lines. dasatinib was more potent than imatinib at inhibiting nonmutated bcr-abl kinase activity. in addition, the kinase activity of 14 out of 15 different clinically relevant, imatinib-resistant bcr-abl isoforms was successfully inhibited [1].
in vivo
mice were dosed with dasatinib or vehicle alone by gavage for 2 weeks, beginning 3 days after injection of ba/f3 cells. all vehicle-treated mice developed progressive disease. in contrast, dasatinib–treated mice harboring nonmutant bcr-abl or the clinically common imatinib-resistant mutation m351t appeared healthy with no evidence of weight loss, lethargy, or ruffled fur and showed more than one log lower levels of bioluminescent activity after 2 weeks of therapy [2].
IC 50
0.55 and 3.0 nm for src and bcr-abl tyrosine kinases, respectively
References
[1] shah np, tran c, lee fy, chen p, norris d, sawyers cl. overriding imatinib resistance with a novel abl kinase inhibitor. science. 2004 jul 16;305(5682):399-401.
[2] monika conchon, carla maria boquimpani de moura freitas, maria aparecida do carmo rego, and josé wilson ramos braga junior. dasatinib -
Dasatinib monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Dasatinib monohydrate Suppliers
- Tel
- --
- Fax
- --
- druginfo@tevausa.com
- Country
- Israel
- ProdList
- 130
- Advantage
- 58
- Tel
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- megan.carroll@tevapharm.com
- Country
- Israel
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View Lastest Price from Dasatinib monohydrate manufacturers
- Product
- Dasatinib Monohydrate 863127-77-9
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-16
- Product
- Dasatinib monohydrate 863127-77-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-13
- Product
- Dasatinib monohydrate 863127-77-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%, Single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2023-12-20