ChemicalBook > CAS DataBase List > SB 743921

SB 743921

Product Name
SB 743921
CAS No.
940929-33-9
Chemical Name
SB 743921
Synonyms
CS-1972;SB 743921;SB-743921 HCl;SB 743921 USP/EP/BP;SB 743921 hydrochloride;SB743921;SB743921; SB 743921;SB-743921 hydrochloride hcl SB743921;(R)-N-(3-Aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylb;(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride;SB 743921; (R)-N-(3-AMINOPROPYL)-N-(1-(3-BENZYL-7-CHLORO-4-OXO-4H-CHROMEN-2-YL)-2-METHYLPROPYL)-4-METHYLBENZAMIDE HYDROCHLORIDE
CBNumber
CB52517941
Molecular Formula
C31H34Cl2N2O3
Formula Weight
553.51926
MOL File
940929-33-9.mol
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SB 743921 Property

storage temp. 
-20°C
solubility 
H2O: soluble5mg/mL, clear
form 
powder
color 
white to beige
InChIKey
MLMZVWABFOLFGV-LNLSOMNWSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1121
Product name
SB743921 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$254
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1121
Product name
SB743921 hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$807
Updated
2024/03/01
Cayman Chemical
Product number
18384
Product name
SB-743921 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18384
Product name
SB-743921 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
18384
Product name
SB-743921 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$278
Updated
2024/03/01
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SB 743921 Chemical Properties,Usage,Production

Uses

SB 743921 Hydrochloride is a mitotic kinesin inhibitor, which can be used to treat lung disease in combination with other therapy.

Biological Activity

sb743921 is an inhibitor of kinesin spindle protein (ksp) with ki value of 0.1nm [1].as an inhibitor of mitotic kinesin ksp, sb743921 causes cell cycle arrest in mitosis, results in cell death. sb743921 is developed to treat for cancers. sb743921 is a potent and selective inhibitor. in the affinity assays, sb743921 shows ki values of 0.1nm and 0.12nm for human ksp and mouse ksp, respectively. it has no affinity with other kinesins. in the cellular assay, sb743921 exerts anti-proliferation efficacy in skov3, colo205, mv522 and mx1 with ic50 values of 0.02nm, 0.07nm, 1.7nm and 0.06nm. moreover, sb743921 is shown to have activity against human tumor xenografts colo205, mcf-7, sk-mes, h69, ovcar-3, ht-29, mda-mb-231 and a2780. sb743921 is also effective against p388 lymphocytic leukemia xenografts in mice [1].

References

[1] jackson j r, gilmartin a, dhanak d, et al. a second generation ksp inhibitor, sb-743921, is a highly potent and active therapeutic in preclinical models of cancer. proceedings of the american association for cancer research, 2006, 2006(2): b11.

SB 743921 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 743921 Suppliers

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View Lastest Price from SB 743921 manufacturers

Career Henan Chemical Co
Product
SB 743921 940929-33-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-02

940929-33-9, SB 743921Related Search:

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  • SB 743921
  • (R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride
  • SB 743921; (R)-N-(3-AMINOPROPYL)-N-(1-(3-BENZYL-7-CHLORO-4-OXO-4H-CHROMEN-2-YL)-2-METHYLPROPYL)-4-METHYLBENZAMIDE HYDROCHLORIDE
  • N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride
  • SB 743921 hydrochloride
  • N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride SB 743921
  • SB 743921 N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride
  • SB-743921 HCl
  • SB743921;SB743921; SB 743921
  • (R)-N-(3-Aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylb
  • CS-1972
  • SB 743921 USP/EP/BP
  • SB-743921 hydrochloride hcl SB743921
  • 940929-33-9
  • C31H33ClN2O3HCl
  • C31H33N2O3HCl
  • C31H34Cl2N2O3
  • Inhibitors
  • apis