ChemicalBook > CAS DataBase List > 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

Product Name
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
CAS No.
327036-89-5
Chemical Name
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
Synonyms
CS-568;NP 01139;TDZD-8/TDZD8;TDZD-8, >=98%;TDZD-8 (NP-01139);GSK-3β Inhibitor I;GSK-3InhibitorI,TDZD-8;TDZD-8;TDZD 8;TDZD8;NP 01139;TDZD8; TDZD 8;GSK-3Β) INHIBITOR I; NP 01139;GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem
CBNumber
CB7501586
Molecular Formula
C10H10N2O2S
Formula Weight
222.26
MOL File
327036-89-5.mol
More
Less

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Property

Melting point:
63-64.4 °C
Boiling point:
335.5±35.0 °C(Predicted)
Density 
1.375±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 18 mg/mL
form 
needles
pka
-2.08±0.20(Predicted)
color 
white
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
WGK Germany 
3
HS Code 
2934999090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T8325
Product name
TDZD-8
Purity
≥98% (HPLC), needles
Packaging
5mg
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
361540
Product name
GSK-3β Inhibitor I
Packaging
5mg
Price
$144
Updated
2024/03/01
TCI Chemical
Product number
B4436
Product name
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Purity
>98.0%(HPLC)
Packaging
5mg
Price
$98
Updated
2024/03/01
TCI Chemical
Product number
B4436
Product name
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$294
Updated
2024/03/01
Cayman Chemical
Product number
16287
Product name
TDZD-8
Purity
≥98%
Packaging
5mg
Price
$61
Updated
2024/03/01
More
Less

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Glycogen Synthase Kinase-3? is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selectiv

Uses

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Definition

ChEBI: TDZD-8 is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, a neuroprotective agent and an anti-inflammatory agent. It is a thiadiazolidine and a member of benzenes.

General Description

A cell-permeable, thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP-competitive inhibitor of GSK-3β (IC50 = 2 μM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 μM, respectively). Does not significantly affect the activities of Cdk1/cyclin B, CK-II, PKA, or PKC (IC50 >100 μM). Shown to inhibit collagen- and thrombin-induced platelet aggregation.

Biological Activity

tdzd-8 is an inhibitor of glycogen synthase kinase-3β (gsk-3β) with ic50 value of 1.4μm [1].tdzd-8 is a potent inhibitor of gsk-3β. it is found to act as a noncompetitive inhibitor of atp binding. tdzd-8 is selective against gsk-3β over other protein kinases including pka, casein kinase ii and cyclin dependent kinase 1 (cdk-1/cyclin b). however, it is also reported that tdzd-8 can inhibit the protein kinase c isoforms pkcβi and pkcδ with ic50 values of 1.4μm and 1.1μm, respectively [1, 2].in cellular assay, tdzd-8 is found to decrease pdt-induced necrosis of neurons and decrease pdt-induced apoptosis of glial cells through inhibiting gsk-3β as well as pkc. besides that, tdzd-8 also has anti-leukemia activity in many primary human leukemia cells. it is probably due to its inhibition of pkc and flt3 [3].

Biochem/physiol Actions

Primary TargetGsk-3β

storage

Store at -20°C

References

[1] komandirov m a, knyazeva e a, fedorenko y p, et al. on the role of phosphatidylinositol 3-kinase, protein kinase b/akt, and glycogen synthase kinase-3β in photodynamic injury of crayfish neurons and glial cells. journal of molecular neuroscience, 2011, 45(2): 229-235.
[2] martinez a, alonso m, castro a, et al. first non-atp competitive glycogen synthase kinase 3 β (gsk-3β) inhibitors: thiadiazolidinones (tdzd) as potential drugs for the treatment of alzheimer's disease. journal of medicinal chemistry, 2002, 45(6): 1292-1299.
[3] guzman m l, li x, corbett c a, et al. rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1, 2, 4-thiadiazolidine, 3, 5 dione (tdzd-8). blood, 2007, 110(13): 4436-4444.

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Suppliers

Americas 1 Canada 1 China 98 Europe 1 Germany 1 India 2 Japan 1 Switzerland 1 United Kingdom 3 United States 23 Global 132
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4553
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9461
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
More
Less

View Lastest Price from 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE manufacturers

Career Henan Chemical Co
Product
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE 327036-89-5
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

327036-89-5, 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONERelated Search:

AR-A014418 Ethacrynic acid SB 415286 1-AZAKENPAULLONE KAHWEOL SEDANOLIDE S-[N-(3-PHENYLPROPYL)(THIOCARBAMOYL)]-L-CYSTEINE CAFESTOL 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE SB216763 Belnacasan (VX-765) Bosutinib Saracatinib Tideglusib Z-VAD-FMK TDZD-8 TD 139 MANZAMINE A

  • GSK-3InhibitorI,TDZD-8
  • NP 01139
  • 1,2,4-Thiadiazolidine-3,5-dione,2-Methyl-4-(phenylMethyl)-
  • TDZD-8/TDZD8
  • 4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione TDZD-8
  • TDZD-8, >=98%
  • TDZD-8;TDZD 8;TDZD8;NP 01139
  • 2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
  • GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem
  • CS-568
  • TDZD8; TDZD 8;GSK-3Β) INHIBITOR I; NP 01139
  • TDZD-8 (NP-01139)
  • GSK-3β Inhibitor I
  • inhibit,TDZD8,Inhibitor,TDZD 8,NP01139,GSK-3,TDZD-8,Glycogen synthase kinase 3,NP-01139,Glycogen synthase kinase-3
  • 327036-89-5
  • Amines
  • Aromatics
  • Sulfur & Selenium Compounds
  • Other Enzyme Inhibitors and Activators.
  • Inhibitors
  • Akt
  • mTOR
  • PI3K