ChemicalBook > CAS DataBase List > 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE

Product Name
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
CAS No.
478482-75-6
Chemical Name
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
Synonyms
TIBPO;GSK3β Inhibitor II;GSK-3 INHIBITOR II;GSK3.beta. Inhibitor II;GLYCOGEN SYNTHASE KINASE-3 INHIBITOR II;GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem;2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE;2-((3-Iodobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole;4-[5-[[(3-Iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine;2-[(3-iodophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
CBNumber
CB2201711
Molecular Formula
C14H10IN3OS
Formula Weight
395.22
MOL File
Mol file
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2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Property

Boiling point:
532.6±60.0 °C(Predicted)
Density 
1.79±0.1 g/cm3(Predicted)
storage temp. 
-20C
solubility 
≤3mg/ml in DMSO;10mg/ml in dimethyl formamide
form 
Yellow solid
pka
0.97±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
361541
Product name
GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem
Packaging
5mg
Price
$141
Updated
2021/12/16
Cayman Chemical
Product number
19077
Product name
GSK3β Inhibitor II
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
19077
Product name
GSK3β Inhibitor II
Purity
≥95%
Packaging
10mg
Price
$176
Updated
2024/03/01
ApexBio Technology
Product number
C4599
Product name
GSK-3βInhibitorII
Packaging
10mg
Price
$198
Updated
2021/12/16
AK Scientific
Product number
9903CP
Product name
GSK-3InhibitorII
Packaging
5mg
Price
$201
Updated
2021/12/16
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2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Chemical Properties,Usage,Production

Definition

ChEBI: 2-[(3-iodophenyl)methylthio]-5-pyridin-4-yl-1,3,4-oxadiazole is an aryl sulfide.

Biological Activity

gsk-3β inhibitor ii is a gsk-3β inhibitor.glycogen synthase kinase-3 (gsk-3), a protein-serine kinase, is implicated in the hormonal control of various regulatory proteins. a number of substrates have been identified, which implicates gsk-3 in the regulation of several physiological processes. moreover, it has been reported that compounds that specifically inhibit gsk-3 activity may be useful in the treatment of diabetes.

in vitro

in a previous study, by using a virtual screening strategy based on a methodology derived from the cats molecular descriptor, a novel compound class including gsk-3β inhibitor ii with inhibitory activity against the gsk-3 enzyme was identified via scaffold hopping. gsk-3β inhibitor ii was found to be a potent inhibitor of gsk-3β with the ic50 value of 390 nm. however, gsk-3β inhibitor ii was not able to inhibit another gsk-3 isoform, gsk-3α [1]. another study found that gsk-3β inhibitor ii could block the functional regulation of p53 through inhibiting gsk-3β, decreasing mdm2 levels, and modulating mitochondrial p53 apoptotic signaling [2].

IC 50

390 nm for gsk-3β

References

[1] naerum, l. ,nrskov-lauritsen, l. and olesen, p.h. scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors. bioorg.med.chem.lett. 12(11), 1525-1528 (2002).
[2] watcharasit, p. ,bijur, g.n.,song, l., et al. glycogen synthase kinase-3beta (gsk3beta) binds to and promotes the actions of p53. j.biol.chem. 278(49), 49972-48879 (2003).

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Suppliers

Shanghai T&W Pharmaceutical Co., Ltd.
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478482-75-6, 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLERelated Search:


  • 2-[(3-iodophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
  • GSK3.beta. Inhibitor II
  • TIBPO
  • 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
  • GLYCOGEN SYNTHASE KINASE-3 INHIBITOR II
  • GSK-3 INHIBITOR II
  • Pyridine, 4-[5-[[(3-iodophenyl)Methyl]thio]-1,3,4-oxadiazol-2-yl]-
  • 4-[5-[[(3-Iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine
  • GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem
  • GSK3β Inhibitor II
  • 2-((3-Iodobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole
  • 478482-75-6