2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE

Product Name: 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
CAS No.: 478482-75-6
Chemical Name: 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
Synonyms: TIBPO;GSK3β Inhibitor II;GSK-3 INHIBITOR II;GSK3.beta. Inhibitor II;GSK3β inhibitor II, 10 mM in DMSO;GLYCOGEN SYNTHASE KINASE-3 INHIBITOR II;GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem;2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE;2-((3-Iodobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole;4-[5-[[(3-Iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine
CBNumber: CB2201711
Molecular Formula: C14H10IN3OS
Formula Weight: 395.22
MOL File: Mol file

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2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Property

Boiling point:: 532.6±60.0 °C(Predicted)
Density: 1.79±0.1 g/cm3(Predicted)
storage temp.: -20C
solubility: ≤3mg/ml in DMSO;10mg/ml in dimethyl formamide
form: Yellow solid
pka: 0.97±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 361541
Product name: GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem
Packaging: 5mg
Price: $141
Updated: 2021/12/16

Cayman Chemical

Product number: 19077
Product name: GSK3β Inhibitor II
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 19077
Product name: GSK3β Inhibitor II
Purity: ≥95%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

ApexBio Technology

Product number: C4599
Product name: GSK-3βInhibitorII
Packaging: 10mg
Price: $198
Updated: 2021/12/16

AK Scientific

Product number: 9903CP
Product name: GSK-3InhibitorII
Packaging: 5mg
Price: $201
Updated: 2021/12/16

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2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Chemical Properties,Usage,Production

Uses

GSK3β inhibitor II is an inhibitor of GSK3β. GSK3β inhibitor II can be used for research of Alzheimer’s disease (AD)[1].

Definition

ChEBI: 2-[(3-iodophenyl)methylthio]-5-pyridin-4-yl-1,3,4-oxadiazole is an aryl sulfide.

Biological Activity

gsk-3β inhibitor ii is a gsk-3β inhibitor.glycogen synthase kinase-3 (gsk-3), a protein-serine kinase, is implicated in the hormonal control of various regulatory proteins. a number of substrates have been identified, which implicates gsk-3 in the regulation of several physiological processes. moreover, it has been reported that compounds that specifically inhibit gsk-3 activity may be useful in the treatment of diabetes.

in vitro

in a previous study, by using a virtual screening strategy based on a methodology derived from the cats molecular descriptor, a novel compound class including gsk-3β inhibitor ii with inhibitory activity against the gsk-3 enzyme was identified via scaffold hopping. gsk-3β inhibitor ii was found to be a potent inhibitor of gsk-3β with the ic50 value of 390 nm. however, gsk-3β inhibitor ii was not able to inhibit another gsk-3 isoform, gsk-3α [1]. another study found that gsk-3β inhibitor ii could block the functional regulation of p53 through inhibiting gsk-3β, decreasing mdm2 levels, and modulating mitochondrial p53 apoptotic signaling [2].

IC 50

390 nm for gsk-3β

References

[1] naerum, l. ,nrskov-lauritsen, l. and olesen, p.h. scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors. bioorg.med.chem.lett. 12(11), 1525-1528 (2002).
[2] watcharasit, p. ,bijur, g.n.,song, l., et al. glycogen synthase kinase-3beta (gsk3beta) binds to and promotes the actions of p53. j.biol.chem. 278(49), 49972-48879 (2003).

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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478482-75-6, 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLERelated Search:

MANZAMINE A AR-A014418 SB216763 Ethacrynic acid 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE SB 415286 1-AZAKENPAULLONE KAHWEOL SEDANOLIDE S-[N-(3-PHENYLPROPYL)(THIOCARBAMOYL)]-L-CYSTEINE CAFESTOL GLYCOGEN

2-[(3-iodophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole

GSK3.beta. Inhibitor II

TIBPO

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE

GLYCOGEN SYNTHASE KINASE-3 INHIBITOR II

GSK-3 INHIBITOR II

Pyridine, 4-[5-[[(3-iodophenyl)Methyl]thio]-1,3,4-oxadiazol-2-yl]-

4-[5-[[(3-Iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine

GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem

GSK3β Inhibitor II

2-((3-Iodobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole

GSK3β inhibitor II, 10 mM in DMSO

478482-75-6