ChemicalBook > CAS DataBase List > NVP-LDE225

NVP-LDE225

Product Name
NVP-LDE225
CAS No.
956697-53-3
Chemical Name
NVP-LDE225
Synonyms
Sonidegib;Erismodegib;LDE225;CS-65;AZP-577;NVP-LDE225;Sonidegib HCL;SONIDEGIB(LDE225);LDE225 (NVP-LDE225);LDE-225 (SONIDEGIB)
CBNumber
CB52515129
Molecular Formula
C26H26F3N3O3
Formula Weight
485.5
MOL File
956697-53-3.mol
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NVP-LDE225 Property

Melting point:
154-157°C
Boiling point:
544.5±50.0 °C(Predicted)
Density 
1.255
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
White solid.
pka
9.53±0.70(Predicted)
color 
Light Purple
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
E615200
Product name
Erismodegib
Packaging
10mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-0904
Product name
Sonidegib
Purity
99.64%
Packaging
50mg
Price
$180
Updated
2021/12/16
ApexBio Technology
Product number
B2266
Product name
LDE225(NVP-LDE225,Erismodegib)
Packaging
10mM(in 1mL DMSO)
Price
$55
Updated
2021/12/16
ChemScene
Product number
CS-0904
Product name
Sonidegib
Purity
99.64%
Packaging
5mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0904
Product name
Sonidegib
Purity
99.64%
Packaging
10mg
Price
$84
Updated
2021/12/16
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NVP-LDE225 Chemical Properties,Usage,Production

Uses

A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic. Potent Hedgehog inhibitor.

Definition

ChEBI: A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as it phosphate salt) for treatment of locally advanced basal cell carcinoma.

Biological Activity

lde225 is a potent and selective inhibitor of smoothened with ic50 values of 1.3nm in mouse and 2.5nm in human, respectively [1].lde225 is screened out from a high-throughput cell-based screen of in-house diversity combinatorial libraries and is developed to be an antagonist of smo. smo is an activator of the hedgehog(hh) signaling pathway and aberrant activation links to tumorigenesis in several cancers. the antitumor efficacy of lde225 has been evaluated in vivo. in the subcutaneous ptch+/-p53-/- medulloblastoma allograft mouse model, lde225 can significantly inhibit tumor growth at a dose of 5mg/kg/day. and in an orthotopic ptch+/-p53-/- medulloblastoma allograft model, lde225 is suggested to penetrate the blood-brain barrier in tumor-bearing animals and cause the tumor growth inhibition after 4 days of treatment. additionally, the preclinical safety assays show that lde225 has no genotoxicity and has good selectivity [1].

target

human Hedgehog

storage

Store at -20°C

References

[1] shifeng pan, xu wu, jiqing jiang, et al. discovery of nvp-lde225, a potent and selective smoothened antagonist. acs med. chem. lett. 2010, 1: 130–134.

NVP-LDE225 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-LDE225 Suppliers

Wuxi KaideRui Pharmaceutical Technology Co., Ltd
Tel
15370852968
Fax
-
Email
1557216087@qq.com
Country
China
ProdList
1947
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55
Shanghai Meiquan Chemical Technology Co., Ltd.
Tel
15802146997; 15802146997
Email
zkq1984@163.com
Country
China
ProdList
324
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58
Beijing Jingzi Pharmaceutical Technology Co., Ltd.
Tel
15011485209
Email
17241816@qq.com
Country
China
ProdList
81
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
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ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
579
Advantage
61
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
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VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
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64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
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View Lastest Price from NVP-LDE225 manufacturers

Career Henan Chemical Co
Product
NVP-LDE225 956697-53-3
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

956697-53-3, NVP-LDE225Related Search:


  • LDE225 (NVP-LDE225)
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  • NVP-LDE225(LDE225,ErisModegib)
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  • NVP-LDE225/erisModegib
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  • AZP-577
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  • CS-65
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  • Erismodegib Diphosphate,LDE225
  • N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide
  • Sonidegib (NVP-LDE225)
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  • SONIDEGIB(LDE225)
  • NVP-LDE225 USP/EP/BP
  • Sonidegib /Erismodegib
  • Sonidegib-d4 (morphonyl D4)Q: What is Sonidegib-d4 (morphonyl D4) Q: What is the CAS Number of Sonidegib-d4 (morphonyl D4) Q: What is the storage condition of Sonidegib-d4 (morphonyl D4)
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  • Sonidegib Erismodegib LDE225 LDE-225
  • LDE-225 (SONIDEGIB)
  • 956697-53-3
  • C26H26F3N3O3
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals