BEZ235 (Tosylate)
- Product Name
- BEZ235 (Tosylate)
- CAS No.
- 1028385-32-1
- Chemical Name
- BEZ235 (Tosylate)
- Synonyms
- BEZ235 (Tosylate);Dactolisib Tosylate;NVP-BEZ 235 Tosylate;BEZ235 p-toluene sulfonate;DACTOLISIB TOSYLATE (BEZ235 TOSYLATE);NVP-BEZ 235 Tosylate (BEZ235 Tosylate);4-methylbenzenesulfonic acid,2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile;2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)- phenyl]propionitrile p-toluenesulfonate salt;4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alpha-dimethylbenzeneacetonitrile 4-methylbenzenesulfonate
- CBNumber
- CB92624096
- Molecular Formula
- C37H31N5O4S
- Formula Weight
- 641.75
- MOL File
- 1028385-32-1.mol
BEZ235 (Tosylate) Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
N-Bromosuccinimide Price
- Product number
- CS-0711
- Product name
- DactolisibTosylate
- Purity
- 99.88%
- Packaging
- 50mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- A3238
- Product name
- BEZ235Tosylate
- Packaging
- 100mg
- Price
- $92
- Updated
- 2021/12/16
- Product number
- CS-0711
- Product name
- DactolisibTosylate
- Purity
- 99.88%
- Packaging
- 100mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CS-0711
- Product name
- DactolisibTosylate
- Purity
- 99.88%
- Packaging
- 200mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- A3238
- Product name
- BEZ235Tosylate
- Packaging
- 500mg
- Price
- $294
- Updated
- 2021/12/16
BEZ235 (Tosylate) Chemical Properties,Usage,Production
Uses
A dual ATP-competitive inhibitor of PI3K and mTOR. p110α, IC50=4 nM; p110β, IC50=75 nM; p110δ, IC50=7 nM; p110γ, IC50=5 nM.
Biological Activity
bez235 is an imidazoquinoline derivative inhibiting both pi3k and mtor kinases with low nanomolar ic50s. it was well tolerated in preclinical animal studies as well as in
References
1. maira sm, stauffer f, brueggen j et al. identification and characterization of nvp-bez235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. mol cancer ther 2008; 7: 1851-1863.2. markman b, tabernero j, krop i et al. phase i safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mtor inhibitor bgt226 in patients with advanced solid tumors. ann oncol 2012; 23: 2399-2408.3. schnell cr, stauffer f, allegrini pr et al. effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor nvp-bez235 on the tumor vasculature: implications for clinical imaging. cancer res 2008; 68: 6598-6607.4. mukherjee b, tomimatsu n, amancherla k et al. the dual pi3k/mtor inhibitor nvp-bez235 is a potent inhibitor of atm- and dna-pkcs-mediated dna damage responses. neoplasia 2012; 14: 34-43.5. serra v, markman b, scaltriti m et al. nvp-bez235, a dual pi3k/mtor inhibitor, prevents pi3k signaling and inhibits the growth of cancer cells with activating pi3k mutations. cancer res 2008; 68: 8022-8030.
BEZ235 (Tosylate) Preparation Products And Raw materials
Raw materials
Preparation Products
BEZ235 (Tosylate) Suppliers
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