ChemicalBook > CAS DataBase List > BEZ235 (Tosylate)

BEZ235 (Tosylate)

Product Name
BEZ235 (Tosylate)
CAS No.
1028385-32-1
Chemical Name
BEZ235 (Tosylate)
Synonyms
BEZ235 (Tosylate);Dactolisib Tosylate;NVP-BEZ 235 Tosylate;BEZ235 p-toluene sulfonate;DACTOLISIB TOSYLATE (BEZ235 TOSYLATE);NVP-BEZ 235 Tosylate (BEZ235 Tosylate);4-methylbenzenesulfonic acid,2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile;2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)- phenyl]propionitrile p-toluenesulfonate salt;4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alpha-dimethylbenzeneacetonitrile 4-methylbenzenesulfonate
CBNumber
CB92624096
Molecular Formula
C37H31N5O4S
Formula Weight
641.75
MOL File
1028385-32-1.mol
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BEZ235 (Tosylate) Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0711
Product name
DactolisibTosylate
Purity
99.88%
Packaging
50mg
Price
$72
Updated
2021/12/16
ApexBio Technology
Product number
A3238
Product name
BEZ235Tosylate
Packaging
100mg
Price
$92
Updated
2021/12/16
ChemScene
Product number
CS-0711
Product name
DactolisibTosylate
Purity
99.88%
Packaging
100mg
Price
$108
Updated
2021/12/16
ChemScene
Product number
CS-0711
Product name
DactolisibTosylate
Purity
99.88%
Packaging
200mg
Price
$180
Updated
2021/12/16
ApexBio Technology
Product number
A3238
Product name
BEZ235Tosylate
Packaging
500mg
Price
$294
Updated
2021/12/16
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BEZ235 (Tosylate) Chemical Properties,Usage,Production

Uses

A dual ATP-competitive inhibitor of PI3K and mTOR. p110α, IC50=4 nM; p110β, IC50=75 nM; p110δ, IC50=7 nM; p110γ, IC50=5 nM.

Biological Activity

bez235 is an imidazoquinoline derivative inhibiting both pi3k and mtor kinases with low nanomolar ic50s. it was well tolerated in preclinical animal studies as well as in

References

1. maira sm, stauffer f, brueggen j et al. identification and characterization of nvp-bez235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. mol cancer ther 2008; 7: 1851-1863.2. markman b, tabernero j, krop i et al. phase i safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mtor inhibitor bgt226 in patients with advanced solid tumors. ann oncol 2012; 23: 2399-2408.3. schnell cr, stauffer f, allegrini pr et al. effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor nvp-bez235 on the tumor vasculature: implications for clinical imaging. cancer res 2008; 68: 6598-6607.4. mukherjee b, tomimatsu n, amancherla k et al. the dual pi3k/mtor inhibitor nvp-bez235 is a potent inhibitor of atm- and dna-pkcs-mediated dna damage responses. neoplasia 2012; 14: 34-43.5. serra v, markman b, scaltriti m et al. nvp-bez235, a dual pi3k/mtor inhibitor, prevents pi3k signaling and inhibits the growth of cancer cells with activating pi3k mutations. cancer res 2008; 68: 8022-8030.

BEZ235 (Tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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BEZ235 (Tosylate) Suppliers

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1028385-32-1, BEZ235 (Tosylate)Related Search:

NVP-BAW2881 NVP-AAM077 Infigratinib NVP-LDE225 NVP-TNKS656 TAE226 (NVP-TAE226) NVP-ADW742 NVP-CGM097 NVP-BEP800 NVP-TAE684 NVP-BEZ 235 Sodium p-toluenesulfonate

  • BEZ235 (Tosylate)
  • NVP-BEZ 235 Tosylate
  • 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alpha-dimethylbenzeneacetonitrile 4-methylbenzenesulfonate
  • NVP-BEZ 235 Tosylate (BEZ235 Tosylate)
  • 2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)- phenyl]propionitrile p-toluenesulfonate salt
  • 4-methylbenzenesulfonic acid,2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile
  • Dactolisib Tosylate
  • DACTOLISIB TOSYLATE (BEZ235 TOSYLATE)
  • BEZ235 p-toluene sulfonate
  • 1028385-32-1
  • C37H31N5O4S
  • C30H23N5OC7H8O3S