NVP-TNKS656
- Product Name
- NVP-TNKS656
- CAS No.
- 1419949-20-4
- Chemical Name
- NVP-TNKS656
- Synonyms
- CS-1333;TNKS656;NVP-TNKS656;TNKS656(NVP-TNKS656);NVP-TNKS656 - TNKS 656;TNKS656; TNKS-656;TNKS 656;1-Piperidineacetamide, N-(cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-;N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide;N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide
- CBNumber
- CB42705091
- Molecular Formula
- C27H34N4O5
- Formula Weight
- 494.58
- MOL File
- 1419949-20-4.mol
NVP-TNKS656 Property
- Boiling point:
- 700.7±70.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 6.66±0.10(Predicted)
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19930
- Product name
- NVP-TNKS656
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 19930
- Product name
- NVP-TNKS656
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 19930
- Product name
- NVP-TNKS656
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $412
- Updated
- 2024/03/01
- Product number
- 19930
- Product name
- NVP-TNKS656
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $765
- Updated
- 2024/03/01
- Product number
- CS-2976
- Product name
- NVP-TNKS656
- Purity
- 99.52%
- Packaging
- 25mg
- Price
- $828
- Updated
- 2021/12/16
NVP-TNKS656 Chemical Properties,Usage,Production
Description
NVP-TNKS656 is an orally bioavailable inhibitor of tankyrase 2 (TNKS2; IC50 = 6 nM). It is selective for TNKS2 over poly(ADP-ribose) polymerase (PARP) 1 and 2 (IC50s = >19 and 32 nM, respectively). NVP-TNKS656 inhibits Wnt ligand-induced signaling with an IC50 value of 3.5 nM in an HEK293 cell reporter assay. In vivo, NVP-TNKS656 (350 mg/kg) reduces Axin 2 mRNA expression, a Wnt/β-catenin target gene, in MMTV-Wnt1 tumor bearing mice.
in vitro
the ic50 value of nvp-tnks656 against parp1, tnks2, parp2, and stf was > 19, 0.006, 32, and 0.0035 μm, respectively [1].
in vivo
the clearance and volume of distribution of nvp-tnks656 were 10 ml/min/kg and 0.6 l/kg after intravenous administration in mice. the exposure and oral bioavailability was 32% and 53%, respectively. in the mouse mammary tumor virus (mmtv)-wnt1 transgenic model, oral administration of nvp-tnks656 (350 mg/kg) activated the wnt signaling over a 24-h time course. nvp-tnks656 treatment reduced the wnt/beta-catenintarget gene axin2 mrna level by 70-80% [1].
References
shultz m d, cheung a k, kirby c a, et al. identification of nvp-tnks656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor[j]. journal of medicinal chemistry, 2013, 56(16): 6495-6511.
NVP-TNKS656 Preparation Products And Raw materials
Raw materials
Preparation Products
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