NVP-TNKS656

ChemicalBook > CAS DataBase List > NVP-TNKS656

Product Name: NVP-TNKS656
CAS No.: 1419949-20-4
Chemical Name: NVP-TNKS656
Synonyms: CS-1333;TNKS656;NVP-TNKS656;TNKS656(NVP-TNKS656);NVP-TNKS656 - TNKS 656;NVP-TNKS656, 10 mM in DMSO;TNKS656; TNKS-656;TNKS 656;1-Piperidineacetamide, N-(cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-;N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide;N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide
CBNumber: CB42705091
Molecular Formula: C27H34N4O5
Formula Weight: 494.58
MOL File: 1419949-20-4.mol

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NVP-TNKS656 Property

Boiling point:: 700.7±70.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 6.66±0.10(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19930
Product name: NVP-TNKS656
Purity: ≥98%
Packaging: 500μg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 19930
Product name: NVP-TNKS656
Purity: ≥98%
Packaging: 1mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 19930
Product name: NVP-TNKS656
Purity: ≥98%
Packaging: 5mg
Price: $412
Updated: 2024/03/01

Cayman Chemical

Product number: 19930
Product name: NVP-TNKS656
Purity: ≥98%
Packaging: 10mg
Price: $765
Updated: 2024/03/01

ChemScene

Product number: CS-2976
Product name: NVP-TNKS656
Purity: 99.52%
Packaging: 25mg
Price: $828
Updated: 2021/12/16

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NVP-TNKS656 Chemical Properties,Usage,Production

Description

NVP-TNKS656 is an orally bioavailable inhibitor of tankyrase 2 (TNKS2; IC₅₀ = 6 nM). It is selective for TNKS2 over poly(ADP-ribose) polymerase (PARP) 1 and 2 (IC₅₀s = >19 and 32 nM, respectively). NVP-TNKS656 inhibits Wnt ligand-induced signaling with an IC₅₀ value of 3.5 nM in an HEK293 cell reporter assay. In vivo, NVP-TNKS656 (350 mg/kg) reduces Axin 2 mRNA expression, a Wnt/β-catenin target gene, in MMTV-Wnt1 tumor bearing mice.

in vitro

the ic50 value of nvp-tnks656 against parp1, tnks2, parp2, and stf was > 19, 0.006, 32, and 0.0035 μm, respectively [1].

in vivo

the clearance and volume of distribution of nvp-tnks656 were 10 ml/min/kg and 0.6 l/kg after intravenous administration in mice. the exposure and oral bioavailability was 32% and 53%, respectively. in the mouse mammary tumor virus (mmtv)-wnt1 transgenic model, oral administration of nvp-tnks656 (350 mg/kg) activated the wnt signaling over a 24-h time course. nvp-tnks656 treatment reduced the wnt/beta-catenintarget gene axin2 mrna level by 70-80% [1].

References

shultz m d, cheung a k, kirby c a, et al. identification of nvp-tnks656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor[j]. journal of medicinal chemistry, 2013, 56(16): 6495-6511.

NVP-TNKS656 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-TNKS656

TNKS656

N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide

NVP-TNKS656 - TNKS 656

TNKS656; TNKS-656;TNKS 656

CS-1333

N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide

1-Piperidineacetamide, N-(cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-

TNKS656(NVP-TNKS656)

NVP-TNKS656, 10 mM in DMSO

1419949-20-4