NVP-AAM077

Product Name: NVP-AAM077
CAS No.: 459836-30-7
Chemical Name: NVP-AAM077
Synonyms: PEAQX;CS-1513;AAM 007;NVP-AAM077;PEAQX sodium;NVP-AAM077Na;PEAQX(NVP-AAM 077);NVP-AAM077 sodium salt;PEAQX,Inhibitor,Ionotropic glutamate receptors,inhibit,iGluR;NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem
CBNumber: CB8497088
Molecular Formula: C17H17BrN3O5P
Formula Weight: 454.21
MOL File: 459836-30-7.mol

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NVP-AAM077 Property

Density: 1.639±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble10mg/mL, clear
form: White solid
pka: 1.19±0.10(Predicted)
color: white to beige
Water Solubility: Soluble in water (10mM)
InChIKey: AJYMYLQKBICSOD-ULMLUZALSA-J

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P1999
Product name: PEAQX tetrasodium hydrate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $212
Updated: 2024/03/01

Sigma-Aldrich

Product number: P1999
Product name: PEAQX tetrasodium hydrate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $741
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.04528
Product name: NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem
Packaging: 5MG
Price: $196
Updated: 2024/03/01

ApexBio Technology

Product number: B4803
Product name: PEAQX
Packaging: 5mg
Price: $189
Updated: 2021/12/16

ChemScene

Product number: CS-3383
Product name: PEAQX tetrasodium hydrate
Purity: ≥98.0%
Packaging: 10mg
Price: $240
Updated: 2021/12/16

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NVP-AAM077 Chemical Properties,Usage,Production

Uses

PEAQX tetrasodium hydrate has been used N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) antagonist in rats and mice.

Biochem/physiol Actions

PEAQX is more specific for N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) than N-methyl-D-aspartate (NMDA) receptor 2B (NR2B) and induces striatal apoptosis. It is less potent in activating caspase-3 than its stereomer NVP-AAM007.

Enzyme inhibitor

This potent NMDA receptor antagonist and experimental anticonvulsant (FW = 542.14 g/mol), also known as NVP-AAM077 and tetrasodium [[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5- quinoxalinyl)methyl] phosphonate, is a competitive antagonist for ionotropic glutamate [N-methyl-D-aspartate] receptors (or GluN receptors). Although originally described as being 100x more active against GluN1/GluN2A receptors versus GluN1/GluN2B receptors, later studies revealed only a 5x difference in affinity. There is no difference in the steady-state levels of inhibition produced by NVP-AAM077 when it was either preapplied or coapplied with glutamate.

storage

-20°C

NVP-AAM077 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-AAM077 Suppliers

China 60 Switzerland 1 United Kingdom 2 United States 7 Global 70

Shanghai Boyle Chemical Co., Ltd.

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Nanjing Chemlin Chemical Co., Ltd

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Shanghai HuanChuan Industry Co.,Ltd.

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Sigma-Aldrich

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Guangzhou Zhiya Chemdrugs Co.,Ltd

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SPIRO PHARMA

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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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459836-30-7, NVP-AAM077Related Search:

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CS-1513

PEAQX(NVP-AAM 077)

3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate

PEAQX tetrasodium hydrate [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1

PEAQX; NVP-AAM077 TETRASODIUM HYDRATE; NVP-AAM 077 TETRASODIUM HYDRATE; PEAQX TETRASODIUM HYDRATE[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1;2;3;4-TETRAHYDRO-2;3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE

NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem

PEAQX

[[[(1s)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]phosphonic acid tetrasodium hydrate

NVP-AAM077

[[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate NVP-AAM077 tetrasodium hydrate

NVP-AAM077 sodium salt

[[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]phosphonic acid

Phosphonic acid, P-[[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]-

AAM 007

PEAQX sodium

PEAQX,Inhibitor,Ionotropic glutamate receptors,inhibit,iGluR

NVP-AAM077Na

((((S)-1-(4-Bromophenyl)ethyl)amino)(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl)phosphonic acid

459836-30-7

C17H17BrN3O5P

API