NVP-AAM077
- Product Name
- NVP-AAM077
- CAS No.
- 459836-30-7
- Chemical Name
- NVP-AAM077
- Synonyms
- PEAQX;CS-1513;AAM 007;NVP-AAM077;PEAQX sodium;NVP-AAM077Na;PEAQX(NVP-AAM 077);NVP-AAM077 sodium salt;PEAQX,Inhibitor,Ionotropic glutamate receptors,inhibit,iGluR;NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem
- CBNumber
- CB8497088
- Molecular Formula
- C17H17BrN3O5P
- Formula Weight
- 454.21
- MOL File
- 459836-30-7.mol
NVP-AAM077 Property
- Density
- 1.639±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- White solid
- pka
- 1.19±0.10(Predicted)
- color
- white to beige
- Water Solubility
- Soluble in water (10mM)
- InChIKey
- AJYMYLQKBICSOD-ULMLUZALSA-J
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P1999
- Product name
- PEAQX tetrasodium hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $212
- Updated
- 2024/03/01
- Product number
- P1999
- Product name
- PEAQX tetrasodium hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $741
- Updated
- 2024/03/01
- Product number
- 5.04528
- Product name
- NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem
- Packaging
- 5MG
- Price
- $196
- Updated
- 2024/03/01
- Product number
- B4803
- Product name
- PEAQX
- Packaging
- 5mg
- Price
- $189
- Updated
- 2021/12/16
- Product number
- CS-3383
- Product name
- PEAQX tetrasodium hydrate
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $240
- Updated
- 2021/12/16
NVP-AAM077 Chemical Properties,Usage,Production
Uses
PEAQX tetrasodium hydrate has been used N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) antagonist in rats and mice.
Biochem/physiol Actions
PEAQX is more specific for N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) than N-methyl-D-aspartate (NMDA) receptor 2B (NR2B) and induces striatal apoptosis. It is less potent in activating caspase-3 than its stereomer NVP-AAM007.
Enzyme inhibitor
This potent NMDA receptor antagonist and experimental anticonvulsant (FW = 542.14 g/mol), also known as NVP-AAM077 and tetrasodium [[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5- quinoxalinyl)methyl] phosphonate, is a competitive antagonist for ionotropic glutamate [N-methyl-D-aspartate] receptors (or GluN receptors). Although originally described as being 100x more active against GluN1/GluN2A receptors versus GluN1/GluN2B receptors, later studies revealed only a 5x difference in affinity. There is no difference in the steady-state levels of inhibition produced by NVP-AAM077 when it was either preapplied or coapplied with glutamate.
storage
-20°C