NVP-BEZ 235

Product Name: NVP-BEZ 235
CAS No.: 915019-65-7
Chemical Name: NVP-BEZ 235
Synonyms: 104794;CS-381;BEZ-235;Dactolisib;NVP-BEZ 235;BEZ235 0.6G;BEZ235, >=98%;NVP-BEZ235(BEZ235);BEZ235 (NVP-BEZ235);Dactolisib (BEZ235)
CBNumber: CB01872365
Molecular Formula: C30H23N5O
Formula Weight: 469.55
MOL File: 915019-65-7.mol

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NVP-BEZ 235 Property

Melting point:: 288-289°C
Boiling point:: 701.0±70.0 °C(Predicted)
Density: 1.299
storage temp.: Refrigerator
solubility: Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75?C).
pka: 6.41±0.20(Predicted)
form: White powder.
color: White or off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
CAS DataBase Reference: 915019-65-7

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10565
Product name: NVP-BEZ235
Purity: ≥98%
Packaging: 25mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10565
Product name: NVP-BEZ235
Purity: ≥98%
Packaging: 50mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 10565
Product name: NVP-BEZ235
Purity: ≥98%
Packaging: 100mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 10565
Product name: NVP-BEZ235
Purity: ≥98%
Packaging: 250mg
Price: $235
Updated: 2024/03/01

TRC

Product number: N925750
Product name: NVP-BEZ235
Packaging: 10mg
Price: $45
Updated: 2021/12/16

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NVP-BEZ 235 Chemical Properties,Usage,Production

Description

NVP-BEZ235 (915019-65-7) is a dual PI3K and mTOR kinase inhibitor.1?It inhibits VEGF-induced proliferation and angiogenesis.2?Reverses lapatinib resistance.3?It induces G1 arrest and reduces cyclin D1 expression in melanoma cells with negligible apoptosis.4?NVP-BEZ235 inhibits the growth of cancer cells with activating PI3K mutations.5?The ability of NVP-BEZ235 to inhibit PI3K has come into question. This study also shows it to be a potent inhibitor of PRKDC (IC50 = 29 nM), ATM (IC50 = 13 nM), and ATR (IC50 = 8 nM).6?Active in vivo.

Chemical Properties

Light Beige Solid

Uses

A dual ATP-competitive inhibitor of PI3K and mTOR. p110α, IC50=4 nM; p110β, IC50=75 nM; p110δ, IC50=7 nM; p110γ, IC50=5 nM.

Uses

Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.[Cayman Chemical]

Uses

Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR.

Definition

ChEBI: An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.

in vivo

BEZ235 induced tumor regression (69%) without a statistically significant effect on weight gain. Taken together, these preliminary in vivo efficacy findings suggest that BEZ235 blocks disease progression when administered orally alone and enhances efficacy when combined with other anticancer drugs.

target

p110α

References

1) Maira et al. (2008), Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity; Mol. Cancer Ther., 7 1851 2) Schnell et al. (2008), Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging; Cancer Res., 68 6598 3) Eichhorn et al. (2008), Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/Phosphatidylinositol 3-kinase inhibitor NVP-BEZ235; Cancer Res., 68 9221 4) Marone et al. (2009), Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors; Mol. Cancer Res., 7 601 5) Serra et al. (2008), NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations; Cancer Res., 68 8022 6) Reinecke?et al. (2019),?Chemoproteomic selectivity profiling of PIKK and PI3K kinase inhibitors; ACS Chem.Biol., 14?655

NVP-BEZ 235 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-BEZ 235 Suppliers

Canada 1 China 187 Germany 1 India 1 The Netherlands 1 United Kingdom 3 United States 28 Global 222

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
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Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
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Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
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Jinan shenlikang chemical technology co. LTD

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Shanghai Boyle Chemical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
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Country: China
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Chembest Research Laboratories Limited

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Capot Chemical Co., Ltd

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Nanjing Chemlin Chemical Co., Ltd

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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
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View Lastest Price from NVP-BEZ 235 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: NVP-BEZ 235 915019-65-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: NVP-BEZ 235 915019-65-7
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-21

915019-65-7, NVP-BEZ 235Related Search:

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester FGF-401 TAE226 (NVP-TAE226) NVP-LCQ195 NVP-TAE684 PENICILLIN V TRIMETHYLPHOSPHINE OXIDE TRIMETHYLSILOXYSILICATE 3-Methacryloxypropyltrimethoxysilane Everolimus Selumetinib MK-2206 2HCl Pictilisib Trametinib Rapamycin N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide NVP-BGT226 NVP-BSK805

4-[2,3-Dihydro-3-Methyl-2-oxo-8-(quinolin-3-yl)-1H-iMidazo[4,5-c]quinolin-1-yl]-alpha,alpha-diMethylbenzeneacetonitrile

BEZ-235

2-methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile

2-Methyl-2-[3-Methyl-2-oxo-8-(3-quinolinyl)-1-iMidazo[4,5-c]quinolinyl]propanenitrile

BEZ235 (NVP-BEZ235, Dactolisib)

2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl

BEZ235 NVP-BEZ235(BEZ235)

Dactolisib

2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile BEZ235(NVP-BEZ235)

NVP-BEZ 235 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile

Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-.alpha.,.alpha.-dimethyl-

4-[2,3-Dihydro-3-Methyl-2-oxo-8-(3-quinolinyl)-1H-iMidazo[4,5-c]quinolin-1-yl]-α,α-diMethyl-benzeneacetonitrile

NVP-BEZ235(BEZ235)

BEZ235, >=98%

104794

Dactolisib (BEZ235, NVP-BEZ235)

CS-381

BEZ-235 (Dactolisib)

2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile Dactolisib

2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phe

NVP-BEZ 235

2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile

2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

BEZ235 0.6G

BEZ235 (NVP-BEZ235)

Dactolisib (BEZ235)

NVP-BEZ235(Dactolisib

NVP-BEZ 235;BEZ-235;BEZ 235;NVP-BEZ235;DACTOLISIB

Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-

NVP-BEZ 235 USP/EP/BP

TIANFU-CHEM BEZ235 (NVP-BEZ235, Dactolisib)

Dactolisib(NVP-BEZ 235)

4-2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo4,5-cquinolin-1-yl-.alpha.,.alpha.-dimethyl-benzeneacetonitrile

915019-65-7

5019-65-7

C30H23N5O

Intermediates & Fine Chemicals

Pharmaceuticals

Protein Kinase Inhibitors and Activators

api

Inhibitors

Akt

mTOR

PI3K