ChemicalBook > CAS DataBase List > NVP-BEZ 235

NVP-BEZ 235

Product Name
NVP-BEZ 235
CAS No.
915019-65-7
Chemical Name
NVP-BEZ 235
Synonyms
104794;CS-381;BEZ-235;Dactolisib;NVP-BEZ 235;BEZ235 0.6G;BEZ235, >=98%;NVP-BEZ235(BEZ235);BEZ235 (NVP-BEZ235);Dactolisib (BEZ235)
CBNumber
CB01872365
Molecular Formula
C30H23N5O
Formula Weight
469.55
MOL File
915019-65-7.mol
More
Less

NVP-BEZ 235 Property

Melting point:
288-289°C
Boiling point:
701.0±70.0 °C(Predicted)
Density 
1.299
storage temp. 
Refrigerator
solubility 
Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75?C).
pka
6.41±0.20(Predicted)
form 
White powder.
color 
White or off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
CAS DataBase Reference
915019-65-7
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
10565
Product name
NVP-BEZ235
Purity
≥98%
Packaging
25mg
Price
$39
Updated
2023/01/06
Cayman Chemical
Product number
10565
Product name
NVP-BEZ235
Purity
≥98%
Packaging
50mg
Price
$69
Updated
2023/01/06
Cayman Chemical
Product number
10565
Product name
NVP-BEZ235
Purity
≥98%
Packaging
100mg
Price
$122
Updated
2023/01/06
Cayman Chemical
Product number
10565
Product name
NVP-BEZ235
Purity
≥98%
Packaging
250mg
Price
$209
Updated
2023/01/06
Usbiological
Product number
018621
Product name
NVP-BEZ 235
Packaging
10mg
Price
$375
Updated
2021/12/16
More
Less

NVP-BEZ 235 Chemical Properties,Usage,Production

Description

NVP-BEZ235 (915019-65-7) is a dual PI3K and mTOR kinase inhibitor.1?It inhibits VEGF-induced proliferation and angiogenesis.2?Reverses lapatinib resistance.3?It induces G1 arrest and reduces cyclin D1 expression in melanoma cells with negligible apoptosis.4?NVP-BEZ235 inhibits the growth of cancer cells with activating PI3K mutations.5?The ability of NVP-BEZ235 to inhibit PI3K has come into question. This study also shows it to be a potent inhibitor of PRKDC (IC50 = 29 nM), ATM (IC50 = 13 nM), and ATR (IC50 = 8 nM).6?Active in vivo.

Chemical Properties

Light Beige Solid

Uses

A dual ATP-competitive inhibitor of PI3K and mTOR. p110α, IC50=4 nM; p110β, IC50=75 nM; p110δ, IC50=7 nM; p110γ, IC50=5 nM.

Uses

Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR.

Uses

Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.[Cayman Chemical]

Definition

ChEBI: An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.

in vivo

BEZ235 induced tumor regression (69%) without a statistically significant effect on weight gain. Taken together, these preliminary in vivo efficacy findings suggest that BEZ235 blocks disease progression when administered orally alone and enhances efficacy when combined with other anticancer drugs.

References

1) Maira et al. (2008), Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity; Mol. Cancer Ther., 7 1851 2) Schnell et al. (2008), Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging; Cancer Res., 68 6598 3) Eichhorn et al. (2008), Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/Phosphatidylinositol 3-kinase inhibitor NVP-BEZ235; Cancer Res., 68 9221 4) Marone et al. (2009), Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors; Mol. Cancer Res., 7 601 5) Serra et al. (2008), NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations; Cancer Res., 68 8022 6) Reinecke?et al. (2019),?Chemoproteomic selectivity profiling of PIKK and PI3K kinase inhibitors; ACS Chem.Biol., 14?655

NVP-BEZ 235 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

NVP-BEZ 235 Suppliers

ShangHai Biochempartner Co.,Ltd
Tel
13720134139 13720134139
Fax
QQ:2853530913
Email
candy@biochempartner.com
Country
China
ProdList
8014
Advantage
62
Shanghai Luofa Biochemical Technology Co., Ltd.
Tel
021-51111890 15317326293
Email
sales@molnova.com
Country
China
ProdList
4195
Advantage
58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
Tel
027-59232304 15387063101
Email
2881924050@qq.com
Country
China
ProdList
9131
Advantage
58
Jinan shenlikang chemical technology co. LTD
Tel
0531-86092839 13153040268
Fax
QQ:2425815073
Email
2425815073@qq.com
Country
China
ProdList
198
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6002
Advantage
61
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18516978288
Fax
010-89508210
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17286
Advantage
55
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19984
Advantage
64
More
Less

View Lastest Price from NVP-BEZ 235 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
NVP-BEZ 235 915019-65-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
NVP-BEZ 235 915019-65-7
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-21

915019-65-7, NVP-BEZ 235Related Search:


  • 4-[2,3-Dihydro-3-Methyl-2-oxo-8-(quinolin-3-yl)-1H-iMidazo[4,5-c]quinolin-1-yl]-alpha,alpha-diMethylbenzeneacetonitrile
  • BEZ-235
  • 2-methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile
  • 2-Methyl-2-[3-Methyl-2-oxo-8-(3-quinolinyl)-1-iMidazo[4,5-c]quinolinyl]propanenitrile
  • BEZ235 (NVP-BEZ235, Dactolisib)
  • 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl
  • BEZ235 NVP-BEZ235(BEZ235)
  • Dactolisib
  • 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile BEZ235(NVP-BEZ235)
  • NVP-BEZ 235 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile
  • Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-.alpha.,.alpha.-dimethyl-
  • 4-[2,3-Dihydro-3-Methyl-2-oxo-8-(3-quinolinyl)-1H-iMidazo[4,5-c]quinolin-1-yl]-α,α-diMethyl-benzeneacetonitrile
  • NVP-BEZ235(BEZ235)
  • BEZ235, >=98%
  • 104794
  • Dactolisib (BEZ235, NVP-BEZ235)
  • CS-381
  • BEZ-235 (Dactolisib)
  • 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile Dactolisib
  • 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phe
  • NVP-BEZ 235
  • 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile
  • 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
  • BEZ235 0.6G
  • BEZ235 (NVP-BEZ235)
  • Dactolisib (BEZ235)
  • NVP-BEZ235(Dactolisib
  • NVP-BEZ 235;BEZ-235;BEZ 235;NVP-BEZ235;DACTOLISIB
  • Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-
  • NVP-BEZ 235 USP/EP/BP
  • TIANFU-CHEM BEZ235 (NVP-BEZ235, Dactolisib)
  • Dactolisib(NVP-BEZ 235)
  • 915019-65-7
  • 5019-65-7
  • C30H23N5O
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators
  • api
  • Inhibitors
  • Akt
  • mTOR
  • PI3K