N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
- Product Name
- N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
- CAS No.
- 362003-83-6
- Chemical Name
- N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
- Synonyms
- NVP 231;CS-1722;NVP-231;NVP231;NVP-231;NVP 231;NVP231;NVP-231(Ceramide Kinase Inhibitor);N-(2-Benzamidobenzo[d]thiazol-6-yl)adamantane-1-carboxamide;adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide;(3r,5r,7r)-N-(2-benzamidobenzo[d]thiazol-6-yl)adamantane-1-carboxamide;N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide;NVP231,inhibit,mcf-7,cancer,cerk,Apoptosis,NVP 231,Inhibitor,NCI-H358,NVP-231
- CBNumber
- CB42518895
- Molecular Formula
- C25H25N3O2S
- Formula Weight
- 431.55
- MOL File
- 362003-83-6.mol
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide Property
- Melting point:
- 246-248 °C(Solv: isopropanol (67-63-0); water (7732-18-5))
- Density
- 1.398±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO: >10mg/mL
- pka
- 9.09±0.70(Predicted)
- form
- powder
- color
- white to off-white
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChI
- InChI=1S/C25H25N3O2S/c29-22(18-4-2-1-3-5-18)28-24-27-20-7-6-19(11-21(20)31-24)26-23(30)25-12-15-8-16(13-25)10-17(9-15)14-25/h1-7,11,15-17H,8-10,12-14H2,(H,26,30)(H,27,28,29)
- InChIKey
- MVSSJPGNLQPWSW-UHFFFAOYSA-N
- SMILES
- C12(C(NC3C=C4SC(NC(=O)C5=CC=CC=C5)=NC4=CC=3)=O)CC3CC(CC(C3)C1)C2
Safety
- WGK Germany
- nwg
N-Bromosuccinimide Price
- Product number
- N9289
- Product name
- NVP-231
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $174
- Updated
- 2024/03/01
- Product number
- N9289
- Product name
- NVP-231
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $733
- Updated
- 2024/03/01
- Product number
- 13858
- Product name
- NVP-231
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 13858
- Product name
- NVP-231
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 13858
- Product name
- NVP-231
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $169
- Updated
- 2024/03/01
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide Chemical Properties,Usage,Production
Description
NVP-231 (362003-83-6) is a reversible inhibitor of ceramide kinase (IC50 = 12 nM).1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture.? NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa.? NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest.2 It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells3 as well as MDA-MB-231 breast cancer cells4.
Uses
A ceramide kinase inhibitors that completely inhibits binding of ceramide to CerK and protects against C2-Cer-induced cell death.
storage
Store at +4°C
References
Graf et al. (2008), Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor; Mol. Pharmacol., 74 925 Pastukhov et al. (2014), The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death; Br. J. Pharmacol., 171 5829 Rivera et al. (2016), Ceramide-1-phosphate regulates cell migration and invasion of human pancreatic cancer cells; Biochem. Pharmacol., 102 107 Schwalm et al. (2020), Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI3-Kinase and Akt; Int. J. Mol. Sci., 21 1396
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide manufacturers
- Product
- N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide 362003-83-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-14