ChemicalBook > CAS DataBase List > NVP-AAM077

NVP-AAM077

Product Name
NVP-AAM077
CAS No.
459836-30-7
Chemical Name
NVP-AAM077
Synonyms
PEAQX;CS-1513;AAM 007;NVP-AAM077;PEAQX sodium;NVP-AAM077Na;PEAQX(NVP-AAM 077);NVP-AAM077 sodium salt;PEAQX,Inhibitor,Ionotropic glutamate receptors,inhibit,iGluR;NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem
CBNumber
CB8497088
Molecular Formula
C17H17BrN3O5P
Formula Weight
454.21
MOL File
459836-30-7.mol
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NVP-AAM077 Property

Density 
1.639±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble10mg/mL, clear
form 
White solid
pka
1.19±0.10(Predicted)
color 
white to beige
Water Solubility 
Soluble in water (10mM)
InChIKey
AJYMYLQKBICSOD-ULMLUZALSA-J
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P1999
Product name
PEAQX tetrasodium hydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$212
Updated
2024/03/01
Sigma-Aldrich
Product number
P1999
Product name
PEAQX tetrasodium hydrate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$741
Updated
2024/03/01
Sigma-Aldrich
Product number
5.04528
Product name
NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem
Packaging
5MG
Price
$196
Updated
2024/03/01
ApexBio Technology
Product number
B4803
Product name
PEAQX
Packaging
5mg
Price
$189
Updated
2021/12/16
ChemScene
Product number
CS-3383
Product name
PEAQX tetrasodium hydrate
Purity
≥98.0%
Packaging
10mg
Price
$240
Updated
2021/12/16
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NVP-AAM077 Chemical Properties,Usage,Production

Uses

PEAQX tetrasodium hydrate has been used N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) antagonist in rats and mice.

Biochem/physiol Actions

PEAQX is more specific for N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) than N-methyl-D-aspartate (NMDA) receptor 2B (NR2B) and induces striatal apoptosis. It is less potent in activating caspase-3 than its stereomer NVP-AAM007.

Enzyme inhibitor

This potent NMDA receptor antagonist and experimental anticonvulsant (FW = 542.14 g/mol), also known as NVP-AAM077 and tetrasodium [[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5- quinoxalinyl)methyl] phosphonate, is a competitive antagonist for ionotropic glutamate [N-methyl-D-aspartate] receptors (or GluN receptors). Although originally described as being 100x more active against GluN1/GluN2A receptors versus GluN1/GluN2B receptors, later studies revealed only a 5x difference in affinity. There is no difference in the steady-state levels of inhibition produced by NVP-AAM077 when it was either preapplied or coapplied with glutamate.

storage

-20°C

NVP-AAM077 Preparation Products And Raw materials

Raw materials

Preparation Products

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459836-30-7, NVP-AAM077Related Search:

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  • CS-1513
  • PEAQX(NVP-AAM 077)
  • 3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate
  • PEAQX tetrasodium hydrate [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1
  • PEAQX; NVP-AAM077 TETRASODIUM HYDRATE; NVP-AAM 077 TETRASODIUM HYDRATE; PEAQX TETRASODIUM HYDRATE[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1;2;3;4-TETRAHYDRO-2;3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
  • NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem
  • PEAQX
  • [[[(1s)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]phosphonic acid tetrasodium hydrate
  • NVP-AAM077
  • [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate NVP-AAM077 tetrasodium hydrate
  • NVP-AAM077 sodium salt
  • [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]phosphonic acid
  • Phosphonic acid, P-[[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]-
  • AAM 007
  • PEAQX sodium
  • PEAQX,Inhibitor,Ionotropic glutamate receptors,inhibit,iGluR
  • NVP-AAM077Na
  • ((((S)-1-(4-Bromophenyl)ethyl)amino)(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl)phosphonic acid
  • 459836-30-7
  • C17H17BrN3O5P
  • API