ChemicalBook > CAS DataBase List > N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

Product Name
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
CAS No.
329196-48-7
Chemical Name
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Synonyms
SANT-2;Hh Signaling Antagonist XIV, SANT-2;Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem;N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide;N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide;Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-
CBNumber
CB42518880
Molecular Formula
C26H26ClN3O4
Formula Weight
479.96
MOL File
329196-48-7.mol
More
Less

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Property

Melting point:
210-211℃
Density 
1.287±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
White powder
pka
10.95±0.10(Predicted)
color 
white to beige
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0644
Product name
SANT-2
Purity
≥95% (HPLC)
Packaging
5mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
21208
Product name
SANT-2
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
21208
Product name
SANT-2
Packaging
10mg
Price
$138
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0644
Product name
SANT-2
Purity
≥95% (HPLC)
Packaging
25mg
Price
$589
Updated
2023/01/07
Cayman Chemical
Product number
21208
Product name
SANT-2
Packaging
25mg
Price
$324
Updated
2024/03/01
More
Less

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Chemical Properties,Usage,Production

Uses

SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG.

General Description

A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 μM).

Biochem/physiol Actions

SANT-2 is a potent sonic hedgehog pathway (shh) antagonist that directly inhibits by binding to the smoothened receptor.

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Suppliers

China 40 United Kingdom 2 United States 8 USA 1 Global 51
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4983
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Beijing Haite lesk Technology Co., Ltd
Tel
15210893940; 15116916250
Fax
QQ: 237008221
Email
chemistryliu@163.com
Country
China
ProdList
7326
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58

329196-48-7, N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamideRelated Search:

JERVINE Hh-Ag 1.3 NVP-LDE225 LDE-225 Diphosphate Purmorphamine

  • N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
  • SANT-2
  • Hh Signaling Antagonist XIV, SANT-2
  • Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-
  • Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem
  • N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide
  • 329196-48-7
  • C25H25ClN3O4