ChemicalBook > CAS DataBase List > N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

Product Name
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
CAS No.
329196-48-7
Chemical Name
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Synonyms
SANT-2;Hh Signaling Antagonist XIV, SANT-2;Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem;N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide;N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide;Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-
CBNumber
CB42518880
Molecular Formula
C26H26ClN3O4
Formula Weight
479.96
MOL File
329196-48-7.mol
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N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Property

Melting point:
210-211℃
Density 
1.287±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
White powder
pka
10.95±0.10(Predicted)
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0644
Product name
SANT-2
Purity
≥95% (HPLC)
Packaging
5mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
21208
Product name
SANT-2
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
21208
Product name
SANT-2
Packaging
10mg
Price
$138
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0644
Product name
SANT-2
Purity
≥95% (HPLC)
Packaging
25mg
Price
$589
Updated
2023/01/07
Cayman Chemical
Product number
21208
Product name
SANT-2
Packaging
25mg
Price
$324
Updated
2024/03/01
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N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Chemical Properties,Usage,Production

Uses

SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG.

General Description

A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 μM).

Biochem/physiol Actions

SANT-2 is a potent sonic hedgehog pathway (shh) antagonist that directly inhibits by binding to the smoothened receptor.

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Suppliers

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329196-48-7, N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamideRelated Search:

JERVINE Hh-Ag 1.3 NVP-LDE225 LDE-225 Diphosphate Purmorphamine

  • N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
  • SANT-2
  • Hh Signaling Antagonist XIV, SANT-2
  • Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-
  • Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem
  • N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide
  • 329196-48-7
  • C25H25ClN3O4