Hh-Ag 1.3

Product Name: Hh-Ag 1.3
CAS No.: 364590-63-6
Chemical Name: Hh-Ag 1.3
Synonyms: (Rac)-SAG;Hh-Ag 1.3;Smoothened Agonist, HCl;Frizzled6 agonist SAG1.3;SAG . dihydrochloride (water soluble);3-Chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide;Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-;3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide,hydrate,dihydrochloride
CBNumber: CB72524538
Molecular Formula: C28H28ClN3OS
Formula Weight: 490.06
MOL File: 364590-63-6.mol

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Hh-Ag 1.3 Property

Boiling point:: 688.6±55.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 10mg/mL
water: 25mg/mL
form: White to off-white solid.
pka: 10?+-.0.40(Predicted)
color: light yellow
Water Solubility: Soluble in water.
Sensitive: Light Sensitive & Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 566660
Product name: Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem
Packaging: 1mg
Price: $371
Updated: 2025/07/31

Sigma-Aldrich

Product number: 566660
Product name: Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem
Packaging: 5mg
Price: $1060
Updated: 2025/07/31

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Hh-Ag 1.3 Chemical Properties,Usage,Production

Uses

Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened). This chlorobenzothiophene compound is a hedgehog pathway agonist that interacts with the heptahelical domain of Smo. SAG is shown to act as an activator at low concentrations, but can inhibit Smo coupling at very high concentrations. The activating effects of SAG will counteract Cyclopamine or Cyclopamine-KAAD inhibition of Smo.

in vivo

SAG (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight-week timepoint in CD-1 mice^[4].
SAG (15-20 mg/kg; i.p.) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice^[5].

Hh-Ag 1.3 Preparation Products And Raw materials

Raw materials

Preparation Products

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Hh-Ag 1.3 Suppliers

China 14 United Kingdom 2 United States 3 Global 19

Shanghai Witofly Chemical Co.,Ltd

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Merck KGaA

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364590-63-6, Hh-Ag 1.3Related Search:

JERVINE NVP-LDE225 LDE-225 Diphosphate N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Purmorphamine

3-Chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide

Smoothened Agonist, HCl

SAG . dihydrochloride (water soluble)

3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide,hydrate,dihydrochloride

Hh-Ag 1.3

Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-

Frizzled6 agonist SAG1.3

(Rac)-SAG

364590-63-6