N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
- Product Name
- N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
- CAS No.
- 329196-48-7
- Chemical Name
- N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
- Synonyms
- SANT-2;Hh Signaling Antagonist XIV, SANT-2;Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem;N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide;N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide;Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-
- CBNumber
- CB42518880
- Molecular Formula
- C26H26ClN3O4
- Formula Weight
- 479.96
- MOL File
- 329196-48-7.mol
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Property
- Melting point:
- 210-211℃
- Density
- 1.287±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- White powder
- pka
- 10.95±0.10(Predicted)
- color
- white to beige
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0644
- Product name
- SANT-2
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 21208
- Product name
- SANT-2
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 21208
- Product name
- SANT-2
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- SML0644
- Product name
- SANT-2
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $589
- Updated
- 2023/01/07
- Product number
- 21208
- Product name
- SANT-2
- Packaging
- 25mg
- Price
- $324
- Updated
- 2024/03/01
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Chemical Properties,Usage,Production
Uses
SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG.
General Description
A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 μM).
Biochem/physiol Actions
SANT-2 is a potent sonic hedgehog pathway (shh) antagonist that directly inhibits by binding to the smoothened receptor.