NVP-LDE225
- Product Name
- NVP-LDE225
- CAS No.
- 956697-53-3
- Chemical Name
- NVP-LDE225
- Synonyms
- Sonidegib;Erismodegib;LDE225;CS-65;AZP-577;NVP-LDE225;Sonidegib HCL;SONIDEGIB(LDE225);LDE225 (NVP-LDE225);LDE-225 (SONIDEGIB)
- CBNumber
- CB52515129
- Molecular Formula
- C26H26F3N3O3
- Formula Weight
- 485.5
- MOL File
- 956697-53-3.mol
NVP-LDE225 Property
- Melting point:
- 154-157°C
- Boiling point:
- 544.5±50.0 °C(Predicted)
- Density
- 1.255
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- White solid.
- pka
- 9.53±0.70(Predicted)
- color
- Light Purple
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- E615200
- Product name
- Erismodegib
- Packaging
- 10mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CS-0904
- Product name
- Sonidegib
- Purity
- 99.64%
- Packaging
- 50mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- B2266
- Product name
- LDE225(NVP-LDE225,Erismodegib)
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-0904
- Product name
- Sonidegib
- Purity
- 99.64%
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0904
- Product name
- Sonidegib
- Purity
- 99.64%
- Packaging
- 10mg
- Price
- $84
- Updated
- 2021/12/16
NVP-LDE225 Chemical Properties,Usage,Production
Uses
A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic. Potent Hedgehog inhibitor.
Definition
ChEBI: A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as it phosphate salt) for treatment of locally advanced basal cell carcinoma.
Biological Activity
lde225 is a potent and selective inhibitor of smoothened with ic50 values of 1.3nm in mouse and 2.5nm in human, respectively [1].lde225 is screened out from a high-throughput cell-based screen of in-house diversity combinatorial libraries and is developed to be an antagonist of smo. smo is an activator of the hedgehog(hh) signaling pathway and aberrant activation links to tumorigenesis in several cancers. the antitumor efficacy of lde225 has been evaluated in vivo. in the subcutaneous ptch+/-p53-/- medulloblastoma allograft mouse model, lde225 can significantly inhibit tumor growth at a dose of 5mg/kg/day. and in an orthotopic ptch+/-p53-/- medulloblastoma allograft model, lde225 is suggested to penetrate the blood-brain barrier in tumor-bearing animals and cause the tumor growth inhibition after 4 days of treatment. additionally, the preclinical safety assays show that lde225 has no genotoxicity and has good selectivity [1].
target
human Hedgehog
storage
Store at -20°C
References
[1] shifeng pan, xu wu, jiqing jiang, et al. discovery of nvp-lde225, a potent and selective smoothened antagonist. acs med. chem. lett. 2010, 1: 130–134.
NVP-LDE225 Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-LDE225 Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
View Lastest Price from NVP-LDE225 manufacturers
- Product
- NVP-LDE225 956697-53-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23