ChemicalBook > CAS DataBase List > NVP-LDE225

NVP-LDE225

Product Name: NVP-LDE225
CAS No.: 956697-53-3
Chemical Name: NVP-LDE225
Synonyms: Sonidegib;Erismodegib;LDE225;CS-65;AZP-577;NVP-LDE225;Sonidegib HCL;SONIDEGIB(LDE225);LDE225 (NVP-LDE225);LDE-225 (SONIDEGIB)
CBNumber: CB52515129
Molecular Formula: C26H26F3N3O3
Formula Weight: 485.5
MOL File: 956697-53-3.mol

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NVP-LDE225 Property

Melting point:: 154-157°C
Boiling point:: 544.5±50.0 °C(Predicted)
Density: 1.255
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
form: White solid.
pka: 9.53±0.70(Predicted)
color: Light Purple
InChIKey: VZZJRYRQSPEMTK-CALCHBBNNA-N
SMILES: C1(C2=CC=C(OC(F)(F)F)C=C2)=CC=CC(C(NC2=CC=C(N3C[C@H](C)O[C@H](C)C3)N=C2)=O)=C1C |&1:24,27,r|

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: E615200
Product name: Erismodegib
Packaging: 10mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-0904
Product name: Sonidegib
Purity: 99.64%
Packaging: 50mg
Price: $180
Updated: 2021/12/16

ApexBio Technology

Product number: B2266
Product name: LDE225(NVP-LDE225,Erismodegib)
Packaging: 10mM(in 1mL DMSO)
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-0904
Product name: Sonidegib
Purity: 99.64%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0904
Product name: Sonidegib
Purity: 99.64%
Packaging: 10mg
Price: $84
Updated: 2021/12/16

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NVP-LDE225 Chemical Properties,Usage,Production

Uses

A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic. Potent Hedgehog inhibitor.

Definition

ChEBI: A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as it phosphate salt) for treatment of locally advanced basal cell carcinoma.

Biological Activity

lde225 is a potent and selective inhibitor of smoothened with ic50 values of 1.3nm in mouse and 2.5nm in human, respectively [1].lde225 is screened out from a high-throughput cell-based screen of in-house diversity combinatorial libraries and is developed to be an antagonist of smo. smo is an activator of the hedgehog(hh) signaling pathway and aberrant activation links to tumorigenesis in several cancers. the antitumor efficacy of lde225 has been evaluated in vivo. in the subcutaneous ptch+/-p53-/- medulloblastoma allograft mouse model, lde225 can significantly inhibit tumor growth at a dose of 5mg/kg/day. and in an orthotopic ptch+/-p53-/- medulloblastoma allograft model, lde225 is suggested to penetrate the blood-brain barrier in tumor-bearing animals and cause the tumor growth inhibition after 4 days of treatment. additionally, the preclinical safety assays show that lde225 has no genotoxicity and has good selectivity [1].

target

human Hedgehog

storage

Store at -20°C

References

[1] shifeng pan, xu wu, jiqing jiang, et al. discovery of nvp-lde225, a potent and selective smoothened antagonist. acs med. chem. lett. 2010, 1: 130–134.

NVP-LDE225 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from NVP-LDE225 manufacturers

Career Henan Chemical Co

Product: NVP-LDE225 956697-53-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

956697-53-3, NVP-LDE225Related Search:

BEZ235 (Tosylate) NVP-AAM077 NVP-TNKS656 TAE226 (NVP-TAE226) NVP-ADW742 NVP-CGM097 NVP-BEP800 NVP-TAE684 NVP-BEZ 235 Hh-Ag 1.3 LDE-225 Diphosphate N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide GANT61 Panobinostat Vismodegib (GDC-0449) Ribociclib PD 0332991 HCl Infigratinib

LDE225 (NVP-LDE225)

[1,1'-Biphenyl]-3-carboxaMide, N-[6-[(2R,6S)-2,6-diMethyl-4-Morpholinyl]-3-pyridinyl]-2-Methyl-4'-(trifluoroMethoxy)-, rel-

NVP-LDE225(LDE225,ErisModegib)

LDE225 (NVP-LDE225,ErisModegib)

NVP-LDE225/erisModegib

ERISMODEGIB,NVP-LDE225

Sonidegib

rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide LDE225 (NVP-LDE225,Erismodegib)

AZP-577

NVP-LDE225

LDE225

Erismodegib

rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide

CS-65

LDE225 (NVP-LDE225,Sonidegib)

N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-yl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide

Sonidegib HCL

LDE225 (NVP-LDE225,ERISMODEGIB);NVP-LDE225

N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4,-(trifluoromethoxy)-[1,1,-biphenyl]-3-carboxamide

Erismodegib Diphosphate,LDE225

N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide

Sonidegib (NVP-LDE225)

NVP-LDE225,Sonidegib

Sonidegib (LDE-225,NVP-LDE225)

N-(6-((2R,6S)-2,6-Dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-ca

Erismodegib (LDE225)

Sonidegib (Erismodegib, NVP-LDE225)

SONIDEGIB(LDE225)

NVP-LDE225 USP/EP/BP

Sonidegib /Erismodegib

Sonidegib-d4 (morphonyl D4)Q: What is Sonidegib-d4 (morphonyl D4) Q: What is the CAS Number of Sonidegib-d4 (morphonyl D4) Q: What is the storage condition of Sonidegib-d4 (morphonyl D4)

N-(6-(cis-2,6-Dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide

Sonidegib Erismodegib LDE225 LDE-225

LDE-225 (SONIDEGIB)

Sonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist

Sonidegib, 10 mM in DMSO

N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide

956697-53-3

C26H26F3N3O3

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