ChemicalBook > CAS DataBase List > NVP-LDE225

NVP-LDE225

Product Name
NVP-LDE225
CAS No.
956697-53-3
Chemical Name
NVP-LDE225
Synonyms
Sonidegib;Erismodegib;LDE225;CS-65;AZP-577;NVP-LDE225;Sonidegib HCL;SONIDEGIB(LDE225);LDE225 (NVP-LDE225);LDE-225 (SONIDEGIB)
CBNumber
CB52515129
Molecular Formula
C26H26F3N3O3
Formula Weight
485.5
MOL File
956697-53-3.mol
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NVP-LDE225 Property

Melting point:
154-157°C
Boiling point:
544.5±50.0 °C(Predicted)
Density 
1.255
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
White solid.
pka
9.53±0.70(Predicted)
color 
Light Purple
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
E615200
Product name
Erismodegib
Packaging
10mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-0904
Product name
Sonidegib
Purity
99.64%
Packaging
50mg
Price
$180
Updated
2021/12/16
ApexBio Technology
Product number
B2266
Product name
LDE225(NVP-LDE225,Erismodegib)
Packaging
10mM(in 1mL DMSO)
Price
$55
Updated
2021/12/16
ChemScene
Product number
CS-0904
Product name
Sonidegib
Purity
99.64%
Packaging
5mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0904
Product name
Sonidegib
Purity
99.64%
Packaging
10mg
Price
$84
Updated
2021/12/16
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NVP-LDE225 Chemical Properties,Usage,Production

Uses

A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic. Potent Hedgehog inhibitor.

Definition

ChEBI: A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as it phosphate salt) for treatment of locally advanced basal cell carcinoma.

Biological Activity

lde225 is a potent and selective inhibitor of smoothened with ic50 values of 1.3nm in mouse and 2.5nm in human, respectively [1].lde225 is screened out from a high-throughput cell-based screen of in-house diversity combinatorial libraries and is developed to be an antagonist of smo. smo is an activator of the hedgehog(hh) signaling pathway and aberrant activation links to tumorigenesis in several cancers. the antitumor efficacy of lde225 has been evaluated in vivo. in the subcutaneous ptch+/-p53-/- medulloblastoma allograft mouse model, lde225 can significantly inhibit tumor growth at a dose of 5mg/kg/day. and in an orthotopic ptch+/-p53-/- medulloblastoma allograft model, lde225 is suggested to penetrate the blood-brain barrier in tumor-bearing animals and cause the tumor growth inhibition after 4 days of treatment. additionally, the preclinical safety assays show that lde225 has no genotoxicity and has good selectivity [1].

target

human Hedgehog

storage

Store at -20°C

References

[1] shifeng pan, xu wu, jiqing jiang, et al. discovery of nvp-lde225, a potent and selective smoothened antagonist. acs med. chem. lett. 2010, 1: 130–134.

NVP-LDE225 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from NVP-LDE225 manufacturers

Career Henan Chemical Co
Product
NVP-LDE225 956697-53-3
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

956697-53-3, NVP-LDE225Related Search:

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  • LDE225 (NVP-LDE225)
  • [1,1'-Biphenyl]-3-carboxaMide, N-[6-[(2R,6S)-2,6-diMethyl-4-Morpholinyl]-3-pyridinyl]-2-Methyl-4'-(trifluoroMethoxy)-, rel-
  • NVP-LDE225(LDE225,ErisModegib)
  • LDE225 (NVP-LDE225,ErisModegib)
  • NVP-LDE225/erisModegib
  • ERISMODEGIB,NVP-LDE225
  • Sonidegib
  • rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide LDE225 (NVP-LDE225,Erismodegib)
  • AZP-577
  • NVP-LDE225
  • LDE225
  • Erismodegib
  • rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
  • CS-65
  • LDE225 (NVP-LDE225,Sonidegib)
  • N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-yl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
  • Sonidegib HCL
  • LDE225 (NVP-LDE225,ERISMODEGIB);NVP-LDE225
  • N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4,-(trifluoromethoxy)-[1,1,-biphenyl]-3-carboxamide
  • Erismodegib Diphosphate,LDE225
  • N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide
  • Sonidegib (NVP-LDE225)
  • NVP-LDE225,Sonidegib
  • Sonidegib (LDE-225,NVP-LDE225)
  • N-(6-((2R,6S)-2,6-Dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-ca
  • Erismodegib (LDE225)
  • Sonidegib (Erismodegib, NVP-LDE225)
  • SONIDEGIB(LDE225)
  • NVP-LDE225 USP/EP/BP
  • Sonidegib /Erismodegib
  • Sonidegib-d4 (morphonyl D4)Q: What is Sonidegib-d4 (morphonyl D4) Q: What is the CAS Number of Sonidegib-d4 (morphonyl D4) Q: What is the storage condition of Sonidegib-d4 (morphonyl D4)
  • N-(6-(cis-2,6-Dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
  • Sonidegib Erismodegib LDE225 LDE-225
  • LDE-225 (SONIDEGIB)
  • N-(6-(cis-2,6-Dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
  • 956697-53-3
  • C26H26F3N3O3
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals