SB216763

ChemicalBook > CAS DataBase List > SB216763

Product Name: SB216763
CAS No.: 280744-09-4
Chemical Name: SB216763
Synonyms: CS-332;SB 216763;SB216763 USP/EP/BP;SB-216763(SB 216763);3-(2,4-Dichlorophenyl)-4-...;GSK-3 Inhibitor IV, SB-216763;3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide;GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem;3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione;3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
CBNumber: CB9493416
Molecular Formula: C19H12Cl2N2O2
Formula Weight: 371.22
MOL File: 280744-09-4.mol

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SB216763 Property

Melting point:: 287-288.6 °C(lit.)
Boiling point:: 598.1±50.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: 20 mg/mL, soluble
form: Orange solid
pka: 7.27±0.60(Predicted)
color: orange
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S3442
Product name: SB 216763
Purity: >98% (HPLC)
Packaging: 5mg
Price: $178
Updated: 2024/03/01

Sigma-Aldrich

Product number: S3442
Product name: SB 216763
Purity: >98% (HPLC)
Packaging: 25mg
Price: $708
Updated: 2024/03/01

TCI Chemical

Product number: B5716
Product name: SB 216763
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $118
Updated: 2024/03/01

TCI Chemical

Product number: B5716
Product name: SB 216763
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $352
Updated: 2024/03/01

Cayman Chemical

Product number: 10010246
Product name: SB 216763
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

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SB216763 Chemical Properties,Usage,Production

Description

SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM.1 Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model.2 Displays neuroprotective effects on cultured neurons.3 SB-216763 maintains mouse embryonic stem cells in a pluripotent state.4?Cell permeable.

Uses

SB 216763 is a potent and selective cell permeale ATP-competitive inhibitor of GSK3a. It stimulates glycogen synthesis in Chang human liver cells.

Uses

SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.

Definition

ChEBI: 3-(2,4-dichlorophenyl)-4-(1-methyl-3-indolyl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.

Biological Activity

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 9 nM for GSK-3 α ); competes with ATP. Has minimal activity against 24 other protein kinases (IC 50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Biochem/physiol Actions

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.

storage

Room temperature

References

1) Coghlan et al. (2000), Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription; Chem. Biol., 7 793 2) Gurrieri et al. (2010), 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis; J. Pharmacol. Exp. Ther., 332 785 3) Cross et al. (2001), Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death; J. Neurochem., 77 94 4) Kirby et al. (2012), Glycogen synthase kinase 3 (GSK3) inhibitor , SB-216763, promotes pluripotency in mouse embryonic stem cells; PLoS One, 7 e39329

SB216763 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB216763 Suppliers

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View Lastest Price from SB216763 manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: SB216763 280744-09-4
Price: US $19.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: SB216763 280744-09-4
Price: US $19.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-11-26

Career Henan Chemical Co

Product: SB216763 280744-09-4
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

280744-09-4, SB216763Related Search:

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CS-332

GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem

SB 216763

3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE

3-(2,4-Dichlorophenyl)-4-...

3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione

SB-216763(SB 216763)

GSK-3 Inhibitor IV, SB-216763

3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione

1H-Pyrrole-2,5-dione, 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-

SB216763 USP/EP/BP

3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide

280744-09-4

C19H12Cl2N2O2

C19H12N2O2Cl2

C19Cl2H12N2O2

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Glycogen Synthase Kinase 3 (GSK3)

Kinase/Phosphatase Biology

Serine/Threonine Kinase Inhibitors

Inhibitors

Akt

mTOR

PI3K

Protein Kinase

Signalling