ChemicalBook > CAS DataBase List > ZM 306416

ZM 306416

Product Name
ZM 306416
CAS No.
690206-97-4
Chemical Name
ZM 306416
Synonyms
CS-616;CB-676475;CB 676475;ZM 306416, >=99%;ZM306416/ZM-306416;ZM 306416 USP/EP/BP;ZM-306416(CB 676475);Gefitinib Impurity 121;ZM 306416 HYDROCHLORIDE;ZM 213689 DisodiuM Salt (MeropeneM iMpurity)
CBNumber
CB3840883
Molecular Formula
C16H13ClFN3O2
Formula Weight
333.74
MOL File
690206-97-4.mol
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ZM 306416 Property

Melting point:
>161°C (dec.)
Boiling point:
434.1±45.0 °C(Predicted)
Density 
1.389±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Methanol (Slightly), Water (Sparingly)
form 
Off-white solid.
pka
5.49±0.30(Predicted)
color 
Light Orange to Brown
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J67265
Product name
ZM-306416 hydrochloride
Purity
98%
Packaging
1mg
Price
$53.2
Updated
2023/06/20
Alfa Aesar
Product number
J67265
Product name
ZM-306416 hydrochloride
Purity
98%
Packaging
10mg
Price
$316
Updated
2023/06/20
Cayman Chemical
Product number
16968
Product name
ZM 306416
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16968
Product name
ZM 306416
Purity
≥98%
Packaging
500μg
Price
$35
Updated
2021/12/16
Cayman Chemical
Product number
16968
Product name
ZM 306416
Purity
≥98%
Packaging
5mg
Price
$87
Updated
2024/03/01
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ZM 306416 Chemical Properties,Usage,Production

Uses

ZM-306416 is a VEGFR inhibitor, inhibiting Src, VEGFR1 and Abl with IC50 of 0.33 μM, 0.33 μM and 1.3 μM, respectively.

Uses

The major metabolite of Meropenem (M225620) - a carbapenem antibiotic - in plasma and urine. This metabolite existed as a mixture of 1-pyrroline and its 2-pyrroline isomer, and the coexistence of the two isomers at equilibrium in aqueous solutions was observed by NMR.

Uses

ZM 306416 an inhibitor of tyrosine kinase RTK signaling pathway involved in anti-cancer agents. Anti-tumor, anti-metastatic agent.

Definition

ChEBI: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine is a member of quinazolines.

Biological Activity

zm 306416 is a selective inhibitor of vegfr with ic50 value of 0.67μm [1]. it is also reported that zm 306416 inhibits egfr with ic50 value less than 10 nm [2].vascular endothelial growth factor receptor (vegfr) is a key element of the extracellular matrix(ecm) and plays an important role in angiogenesis cooperating with its ligand vegf. several studies have demonstrated that vegfrs expressed in liquid and solid tumor cells, such as nsclc, melanoma, prostate cancer, leukemia, mesothelioma, and breast cancer and are being regarded as a promising target in clinical [3].zm 306416 is a potent vegfr inhibitor and has a different selectivity with other reported vegfr inhibitors. using a549-egfrb cells for egfrb assay revealed that zm 306416 exhibited inhibitory activity on vegfr with ic50 value of 670 nm [1]. when tested with human thyroid follicular cells, zm 306416 treatment exhibited function on reducing vegfr2 phosphorylation and inhibiting endogenous, steady-state levels of p42/44 mapk phosphorylation [4].

target

VEGFR1

References

1. antczak, c., et al., a high-content biosensor-based screen identifies cell-permeable activators and inhibitors of egfr function: implications in drug discovery. j biomol screen, 2012. 17(7): p. 885-99.2. choi kj, baik ih, ye sk et al. molecular targeted therapy for hepatocellular carcinoma: present status and future directions. biol pharm bull. 2015;38(7):986-91. 3. choi, k.j., et al., molecular targeted therapy for hepatocellular carcinoma: present status and future directions. biol pharm bull, 2015. 38(7): p. 986-91.4. susarla, r., j.c. watkinson, and m.c. eggo, regulation of human thyroid follicular cell function by inhibition of vascular endothelial growth factor receptor signalling. mol cell endocrinol, 2012. 351(2): p. 199-207.

ZM 306416 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZM 306416 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
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View Lastest Price from ZM 306416 manufacturers

Career Henan Chemical Co
Product
ZM 306416 690206-97-4
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

690206-97-4, ZM 306416Related Search:


  • ZM 306416 HYDROCHLORIDE
  • 4-[(4'-CHLORO-2'-FLUORO)PHENYLAMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE
  • 4-QuinazolinaMine,N-(4-chloro-2-fluorophenyl)-6,7-diMethoxy-
  • ZM306416/ZM-306416
  • CB 676475
  • CB-676475
  • ZM 213689 DisodiuM Salt (MeropeneM iMpurity) (Mixture of double bond isoMers)
  • N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine
  • N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
  • ZM-306416(CB 676475)
  • N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
  • ZM 306416, >=99%
  • CS-616
  • ZM 213689 DisodiuM Salt (MeropeneM iMpurity)
  • ZM-306416;ZM 306416;CB 676475;ZM-306416;ZM306416;CB-676475;CB676475
  • ZM 306416 USP/EP/BP
  • N-(4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
  • ZM-306416,CB-676475,VEGFR,Inhibitor,ZM 306416,ZM306416,CB676475,inhibit,Vascular endothelial growth factor receptor
  • Gefitinib Impurity 121
  • 690206-97-4
  • C17H25N3Na2O6S
  • C16H13N3O2FClHCl
  • Inhibitors
  • Angiogenesis and Metastasis