ZM 241385

Product Name: ZM 241385
CAS No.: 139180-30-6
Chemical Name: ZM 241385
Synonyms: CS-2353;ZM 241385;ZM241385, 10 mM in DMSO;ZM 241385, A2A antagonist;ZM 241385; ZM241385; ZM-241385;Adenosine A2A Receptor Antagonist I, ZM 241385;4-(2-[7-AMINO-2-(2-FURYL)[1,2,4]TRIAZOLO[2,3-A][1,3,5]TRIAZIN-5-YLAMINO]ETHYL)PHENO;4-(2-[7-AMINO-2-(2-FURYL)[1,2,4]TRIAZOLO[2,3-A][1,3,5]TRIAZIN-5-YLAMINO]ETHYL)PHENOL;4-(2-(7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol;Phenol, 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]-
CBNumber: CB4121732
Molecular Formula: C16H15N7O2
Formula Weight: 337.34
MOL File: 139180-30-6.mol

More

Less

ZM 241385 Property

Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: >15mg/mL
pka: 10.03±0.15(Predicted)
form: powder
color: white to tan
InChI: InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)
InChIKey: PWTBZOIUWZOPFT-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(CCNC2N=C(N)N3N=C(C4=CC=CO4)N=C3N=2)C=C1

More

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 46
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Z0153
Product name: ZM 241385
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105.45
Updated: 2025/07/31

Sigma-Aldrich

Product number: Z0153
Product name: ZM 241385
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $449
Updated: 2025/07/31

Sigma-Aldrich

Product number: 119149
Product name: Adenosine A2A Receptor Antagonist I, ZM 241385 - CAS 139180-30-6 - Calbiochem
Purity: A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).
Packaging: 5MG
Price: $136
Updated: 2025/07/31

TCI Chemical

Product number: Z0042
Product name: ZM 241385
Packaging: 10MG
Price: $192
Updated: 2025/07/31

Cayman Chemical

Product number: 20447
Product name: ZM 241385
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

More

Less

ZM 241385 Chemical Properties,Usage,Production

Uses

ZM 241385 is a selective and potent Adenosine A2A-R antagonist.

Definition

ChEBI: 4-[2-[[7-amino-2-(2-furanyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]phenol is a diamino-1,3,5-triazine.

Biochem/physiol Actions

ZM 241385 is a potent selective adenosine A2A antagonist. The A2A receptor plays a role in regulating myocardial oxygen consumption and coronary blood flow and is highly expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. ZM 241385 has neuroprotective effects and is being investigated for use in Parkinson′s and other neurodegenerative disorders.

Synthesis

51-67-2

139181-28-5

139180-30-6

A reaction was carried out in acetonitrile (25 mL) with p-hydroxyphenethylamine (tyramine, 490 mg, 3.75 mmol) and 2-(furan-2-yl)-5-(methylsulfonyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine (250 mg, 892 μmol). The reaction mixture was stirred at room temperature for 22 hours. Upon completion of the reaction, the solvent was removed by evaporation and the residue was adsorbed through diatomaceous earth and purified using column chromatography (eluent: dichloromethane/methanol, 25:75, v/v). The target product grade was collected, evaporated to dryness and subsequently recrystallized from ethyl acetate to afford 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)phenol (100 mg, 33% yield) as a white solid, melting point: 229-231 °C (literature value: 225- 227°C). The product was analyzed and confirmed by 1H NMR, 13C NMR, high resolution mass spectrometry (HRMS) and high performance liquid chromatography (HPLC).1H NMR (400 MHz, d6-DMSO, 353 K) δ 8.91 (s, 1H), 7.92 (br s, 2H), 7.79 (m, 1H), 7.14 (br t, 1H), 7.04 (m, 3H) , 6.71 (m, 2H), 6.64 (dd, J = 3.3, 1.8 Hz, 1H), 3.49 (m, 2H), 2.78 (m, 2H).13C NMR (101 MHz, d6-DMSO) δ 161.1 (C), 159.0 (C), 155.9 (C), 155.4 (C), 150.1 (C), 146.1 (C), 146.1 (C), 146.1 (C), 146.1 (C), 146.1 (C), 146.1 (C). 146.1 (C), 144.1 (CH), 129.1 (CH), 115.0 (CH), 111.4 (CH), 111.2 (CH), 42.4 (CH2), 33.9 (CH2). HRMS (C16H15N7O2): Calculated value 338.1360 [M + H]+, measured value 338.1353. HPLC : tR 7.34 min, purity 98% (214 nm), 97% (254 nm).

storage

Room temperature

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 11, p. 3427 - 3433
[2] Structural Chemistry, 2013, vol. 24, # 4, p. 1241 - 1251
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 2, p. 718 - 738
[4] Molecular Pharmacology, 1995, vol. 48, # 6, p. 970 - 974
[5] Patent: US5270311, 1993, A

ZM 241385 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ZM 241385 Suppliers

China 107 China Hong Kong 1 Germany 1 India 1 Japan 1 United Kingdom 4 United States 15 Global 130

Shanghai Jinyin Biological Technology Co., Ltd

Tel: 021-20986266 18019349802
Email: 814527417@qq.com
Country: China
ProdList: 461
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Ascent Scientific

Tel: 4401179829988
Fax: 4402030 700 369
Email: customerservice@ascentscientific.co.uk
Country: United Kingdom
ProdList: 279
Advantage: 60

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

More

Less

View Lastest Price from ZM 241385 manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: ZM241385 139180-30-6
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-13

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: ZM241385 139180-30-6
Price: US $100.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-15

Career Henan Chemical Co

Product: ZM 241385 139180-30-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-20

139180-30-6, ZM 241385Related Search:

ZM223 ZM 39923 HYDROCHLORIDE ZM306416 Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]- ZM 323881 hydrochloride ZM 447439 ZM 336372 ZM 39923 HCl ZM 306416 (3H)-ZM 241385 ZM 241385, [2-3H] 1H-1,2,4-Triazole-1-carboximidamide hydrochloride 1,3-DIMETHYL-1H-1,2,4-TRIAZOL-5-AMINE ZM 241385 7-Amino-s-triazolo[1,5-a]-s-triazine ZM 306416 hydrochloride

4-(2-[7-AMINO-2-(2-FURYL)[1,2,4]TRIAZOLO[2,3-A][1,3,5]TRIAZIN-5-YLAMINO]ETHYL)PHENO

Phenol, 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]-

4-(2-[7-AMINO-2-(2-FURYL)[1,2,4]TRIAZOLO[2,3-A][1,3,5]TRIAZIN-5-YLAMINO]ETHYL)PHENOL

ZM 241385

4-(2-(7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol

CS-2353

ZM 241385; ZM241385; ZM-241385

7-amino-2-(furan-2-yl)-5-[2-(4-hydroxyphenyl)ethyl]amino-[1,2,4]triazolo[1,5-a][1,3,5]triazine

ZM 241385, A2A antagonist

ZM241385, 10 mM in DMSO

Adenosine A2A Receptor Antagonist I, ZM 241385

139180-30-6

C16H15N7O2

Adenosine