ZPCK

Product Name: ZPCK
CAS No.: 26049-94-5
Chemical Name: ZPCK
Synonyms: ZPCK;SL-01;Z-PHE-CMK;NSC 251810;Z-L-Phe-CMK;Z-PHE-CH2CL;ZPCK USP/EP/BP;Z-L-Phe-Chloromethane;Z-PHE-CHLOROMETHYLKETONE;z-l-phe chloromethyl ketone
CBNumber: CB0674649
Molecular Formula: C18H18ClNO3
Formula Weight: 331.79
MOL File: 26049-94-5.mol

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ZPCK Property

Melting point:: 107-108 °C(lit.)
Boiling point:: 503.1±50.0 °C(Predicted)
Density: 1.1630 (rough estimate)
refractive index: 1.6470 (estimate)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
pka: 10.74±0.46(Predicted)
form: solid
color: White
optical activity: [α]23/D +30°, c = 1 in chloroform
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Major Application: peptide synthesis
InChI: 1S/C18H18ClNO3/c19-12-17(21)16(11-14-7-3-1-4-8-14)20-18(22)23-13-15-9-5-2-6-10-15/h1-10,16H,11-13H2,(H,20,22)/t16-/m0/s1
InChIKey: OYHLRJGDELITAF-INIZCTEOSA-N
SMILES: ClCC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2
CAS DataBase Reference: 26049-94-5
EPA Substance Registry System: Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-27-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
TSCA: TSCA listed
HS Code: 29225000
Storage Class: 8A - Combustible corrosive hazardous materials
Hazard Classifications: Skin Corr. 1B

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 860794
Product name: Z-L-Phe chloromethyl ketone
Purity: 98%
Packaging: 1g
Price: $270
Updated: 2025/07/31

Cayman Chemical

Product number: 15225
Product name: SL 01
Purity: ≥98%
Packaging: 250mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 15225
Product name: SL 01
Purity: ≥98%
Packaging: 1g
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 15225
Product name: SL 01
Purity: ≥98%
Packaging: 500mg
Price: $68
Updated: 2024/03/01

TRC

Product number: S560010
Product name: SL01
Packaging: 50mg
Price: $45
Updated: 2021/12/16

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ZPCK Chemical Properties,Usage,Production

Description

SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ.

Chemical Properties

white powder

Uses

SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.

Uses

Enzyme inhibitor.

Uses

ZPCK's a peptidase from baker's yeast,and it is with esterase activities of carboxypeptidase Y.

reaction suitability

reaction type: solution phase peptide synthesis

References

[1] JING LI . A Cell-Based High-Throughput Assay for the Screening of Small-Molecule Inhibitors of p53–MDM2 Interaction[J]. SLAS Discovery, 2011, 16 4: Pages 450-456. DOI:10.1177/1087057111399191

ZPCK Preparation Products And Raw materials

Raw materials

Preparation Products

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ZPCK Suppliers

Belgium 1 China 82 Germany 1 India 1 Japan 2 Switzerland 1 United States 13 Global 101

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44802
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
ProdList: 1856
Advantage: 62

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

26049-94-5, ZPCKRelated Search:

ZM 336372 ZM 39923 HYDROCHLORIDE Z-NVA-OH Z-N-Methyl-D-valine ZOTAROLIMUS Z-ORN(BOC)-OH Z-NLE-OH 1-CHLORO-4-PHENYLBUTANE N-Cbz-L-Phenylalanine ZPCK,ZPCK N-CBZ-L-Phenylethyl chloromethyl ketone,N-CBZ-L-PHENYLALANYL-CHLOROMETHYLKETONE AURORA KA-7111 ZPCK 1-CHLOROBUTANONE Z-APF-CMK Z-P-FLUORO-PHE-CHLOROMETHYLKETONE CBZ-L-PHENYLALANINAL METHYL-(3-PENTYL)-AMINE HCL ETHYL (2-PHENYLETHYL)CARBAMATE

SL-01

carbamicacid,[3-chloro-2-oxo-1-(phenylmethyl)propyl]-,phenylmethylester,(s

(S)-benzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate

N-CBZ-L-PHENYLALANINE CHLOROMETHYL*KETON E

z-l-phe chloromethyl ketone

(S)-Penzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate.

ZPCK, N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketone

(3S)-1-Chloro-3-(benzyloxycarbonylamino)-4-phenyl-2-butanone

[(S)-1-Benzyl-3-chloro-2-oxopropyl]carbamic acid benzyl ester

[(S)-α-(Chloroacetyl)phenethyl]carbamic acid benzyl ester

Z-L-Phe-Chloromethane

N-Carbobenzyloxy-L-phenylalanyl chloromethylketone,98%

N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketoneN-CBZ-L-Phenylalanylchloromethyl ketone

NSC 251810

(S)-(1-benzyl-3-chloro-2-oxopropyl)carbamic

Z-L-Phe chloromethyl ketone 98%

(S)-Benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate

Z-L-Phe-CMK

Z-L-PHENYLALANINE-CHLOROMETHYLKETONE

Z-PHE-CH2CL

Z-PHE-CHLOROMETHYLKETONE

Z-PHE-CMK

ZPCK

N-CBZ-L-PHENYLETHYL CHLOROMETHYL KETONE

N-CBZ-L-PHENYLALANYL-CHLOROMETHYLKETONE

N-CARBOBENZYLOXY-L-PHENYLALANYL CHLOROMETHYL KETONE

N-ALPHA-CARBOBENZOXY-L-PHENYLALANINE CHLOROMETHYLKETONE

benzyl N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate

Carbamic acid, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester

ZPCK USP/EP/BP

CBZ-L-Phe-Chloromethyl ketone

(S)-Benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate , ZPCK

Z-<sc>L</sc>-Phe chloromethyl ketone

26049-94-5

C6H5CH2CHNHCO2CH2C6H5COCH2Cl

Phenylalanine Derivatives

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives