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ZPCK

Product Name
ZPCK
CAS No.
26049-94-5
Chemical Name
ZPCK
Synonyms
ZPCK;SL-01;Z-PHE-CMK;NSC 251810;Z-L-Phe-CMK;Z-PHE-CH2CL;ZPCK USP/EP/BP;Z-L-Phe-Chloromethane;Z-PHE-CHLOROMETHYLKETONE;z-l-phe chloromethyl ketone
CBNumber
CB0674649
Molecular Formula
C18H18ClNO3
Formula Weight
331.79
MOL File
26049-94-5.mol
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ZPCK Property

Melting point:
107-108 °C(lit.)
Boiling point:
503.1±50.0 °C(Predicted)
Density 
1.1630 (rough estimate)
refractive index 
1.6470 (estimate)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
pka
10.74±0.46(Predicted)
form 
solid
color 
White
optical activity
[α]23/D +30°, c = 1 in chloroform
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference
26049-94-5
EPA Substance Registry System
Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-36/37/39-45
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
HS Code 
29225000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
860794
Product name
Z-L-Phe chloromethyl ketone
Purity
98%
Packaging
1g
Price
$270
Updated
2025/07/31
Cayman Chemical
Product number
15225
Product name
SL 01
Purity
≥98%
Packaging
250mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
15225
Product name
SL 01
Purity
≥98%
Packaging
1g
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
15225
Product name
SL 01
Purity
≥98%
Packaging
500mg
Price
$68
Updated
2024/03/01
TRC
Product number
S560010
Product name
SL01
Packaging
50mg
Price
$45
Updated
2021/12/16
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ZPCK Chemical Properties,Usage,Production

Description

SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ.

Chemical Properties

white powder

Uses

SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.

Uses

Enzyme inhibitor.

Uses

ZPCK's a peptidase from baker's yeast,and it is with esterase activities of carboxypeptidase Y.

reaction suitability

reaction type: solution phase peptide synthesis

References

[1] JING LI . A Cell-Based High-Throughput Assay for the Screening of Small-Molecule Inhibitors of p53–MDM2 Interaction[J]. SLAS Discovery, 2011, 16 4: Pages 450-456. DOI:10.1177/1087057111399191

ZPCK Preparation Products And Raw materials

Raw materials

Preparation Products

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ZPCK Suppliers

Belgium 1 China 82 Germany 1 India 1 Japan 2 Switzerland 1 United States 13 Global 101
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26049-94-5, ZPCKRelated Search:

ZM 336372 ZM 39923 HYDROCHLORIDE Z-NVA-OH Z-N-Methyl-D-valine ZOTAROLIMUS Z-ORN(BOC)-OH Z-NLE-OH 1-CHLORO-4-PHENYLBUTANE N-Cbz-L-Phenylalanine ZPCK,ZPCK N-CBZ-L-Phenylethyl chloromethyl ketone,N-CBZ-L-PHENYLALANYL-CHLOROMETHYLKETONE AURORA KA-7111 ZPCK 1-CHLOROBUTANONE Z-APF-CMK Z-P-FLUORO-PHE-CHLOROMETHYLKETONE CBZ-L-PHENYLALANINAL METHYL-(3-PENTYL)-AMINE HCL ETHYL (2-PHENYLETHYL)CARBAMATE

  • SL-01
  • carbamicacid,[3-chloro-2-oxo-1-(phenylmethyl)propyl]-,phenylmethylester,(s
  • (S)-benzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate
  • N-CBZ-L-PHENYLALANINE CHLOROMETHYL*KETON E
  • z-l-phe chloromethyl ketone
  • (S)-Penzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate.
  • ZPCK, N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketone
  • (3S)-1-Chloro-3-(benzyloxycarbonylamino)-4-phenyl-2-butanone
  • [(S)-1-Benzyl-3-chloro-2-oxopropyl]carbamic acid benzyl ester
  • [(S)-α-(Chloroacetyl)phenethyl]carbamic acid benzyl ester
  • Z-L-Phe-Chloromethane
  • N-Carbobenzyloxy-L-phenylalanyl chloromethylketone,98%
  • N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketoneN-CBZ-L-Phenylalanylchloromethyl ketone
  • NSC 251810
  • (S)-(1-benzyl-3-chloro-2-oxopropyl)carbamic
  • Z-L-Phe chloromethyl ketone 98%
  • (S)-Benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
  • Z-L-Phe-CMK
  • Z-L-PHENYLALANINE-CHLOROMETHYLKETONE
  • Z-PHE-CH2CL
  • Z-PHE-CHLOROMETHYLKETONE
  • Z-PHE-CMK
  • ZPCK
  • N-CBZ-L-PHENYLETHYL CHLOROMETHYL KETONE
  • N-CBZ-L-PHENYLALANYL-CHLOROMETHYLKETONE
  • N-CARBOBENZYLOXY-L-PHENYLALANYL CHLOROMETHYL KETONE
  • N-ALPHA-CARBOBENZOXY-L-PHENYLALANINE CHLOROMETHYLKETONE
  • benzyl N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate
  • Carbamic acid, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester
  • ZPCK USP/EP/BP
  • CBZ-L-Phe-Chloromethyl ketone
  • (S)-Benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate , ZPCK
  • Z-<sc>L</sc>-Phe chloromethyl ketone
  • 26049-94-5
  • C6H5CH2CHNHCO2CH2C6H5COCH2Cl
  • Phenylalanine Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives