CL 82198 HYDROCHLORIDE

Product Name: CL 82198 HYDROCHLORIDE
CAS No.: 307002-71-7
Chemical Name: CL 82198 HYDROCHLORIDE
Synonyms: CL-82198 (CL82198;CL 82198 hydrochlori;CL 82198 HYDROCHLORIDE;N-(4-Morpholinobutyl)benzofuran-2-carboxamide;N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide;2-Benzofurancarboxamide, N-[4-(4-morpholinyl)butyl]-;Benzofuran-2-carboxylic acid (4-morpholin-4-yl-butyl)-amide;N-(4-Morpholinobutyl)benzofuran-2-carboxamide hydrochloride;N-[4-(4-MORPHOLINYL)BUTYL]-2-BENZOFURANCARBOXAMIDE HYDROCHLORIDE;N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide,hydrochloride
CBNumber: CB42450342
Molecular Formula: C17H22N2O3
Formula Weight: 302.37
MOL File: 307002-71-7.mol

More

Less

CL 82198 HYDROCHLORIDE Property

Boiling point:: 515.6±40.0 °C(Predicted)
Density: 1.159±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
form: powder
pka: 14.19±0.46(Predicted)
color: white to off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C9498
Product name: CL-82198
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Sigma-Aldrich

Product number: C9498
Product name: CL-82198
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $371
Updated: 2024/03/01

Cayman Chemical

Product number: 16928
Product name: CL-82198
Purity: ≥95%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 16928
Product name: CL-82198
Purity: ≥95%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 16928
Product name: CL-82198
Purity: ≥95%
Packaging: 25mg
Price: $270
Updated: 2024/03/01

More

Less

CL 82198 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 μg/ml. It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme. CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.

Uses

CL-82198 is a selective inhibitor of human collagenase-3, known as matrix metalloproteinase-13.

Biological Activity

Selective inhibitor of MMP-13 (89% inhibition at 10 μ g/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.

Biochem/physiol Actions

CL-82198 is a selective inhibitor of MMP-13 that displays no activity at MMP-1, MMP-9 or TACE. It is also a selective S1′ pocket binder, binding within the entire S1′ pocket of MMP-13, docking with the morpholine ring adjacent to the catalytic zinc atom without zinc chelation.

in vitro

cl-82198 was identified as a weak inhibitor against mmp-13 and demonstrated no activity against mmp-1, mmp-9, or the related enzyme tace. bearing drug-like properties, cl-82198 was regarded as an ideal candidate for optimization of enzyme potency and selectivity. in nmr binding studies, it was shown that cl-82198 bound within the entire s1’ pocket of mmp-13, which was the basis of its selectivity against mmp-1, mmp-9, and tace [1].

in vivo

to investigate the contribution of mmp-13 down-regulation during gastroprotection by acetaminophen, the effects of cl-82198 on ibp-induced gastric damage were evaluated. results showed that cl-82198 decreased gastric lesions in a dose-dependent manner in the presence of ibp. compared with ibp administration alone, cl-82198 administered at 0.2 and 1.0 mg/kg resulted in 40.3% and 72.1% decrease in gastric lesion, respectively [1].

IC 50

89% inhibition at 10μg/ml

References

1) Chen, et al. (2000), Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design; J. Am. Chem. Soc., 122 9648

CL 82198 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CL 82198 HYDROCHLORIDE Suppliers

China 36 India 1 United Kingdom 1 United States 13 USA 1 Global 52

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Shanghai Balmxy Pharmaceutical Co., Ltd

Tel: 021-24206007 13764915196
Fax: 86-021-23027023
Email: sales@balmxy.com
Country: China
ProdList: 6765
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4182
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8014
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131980
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3250
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30250
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 10018
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9412
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd

Tel: 13522808617
Email: omiget@qq.com
Country: China
ProdList: 9213
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 3258
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 18768175414
Email: gaojun@univ-bio.com
Country: China
ProdList: 24998
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 6975
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815987 13927875076
Fax: 0751-2828607
Email: 3007432263@qq.com
Country: China
ProdList: 9977
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62163
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 18779
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27996
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50471
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 15801958784
Email: lihua@jskchem.com
Country: China
ProdList: 49242
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48465
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9268
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32836
Advantage: 60

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Shanghai Yijie Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: SHYIJIEBIO@126.COM
Country: CHINA
ProdList: 3510
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

307002-71-7, CL 82198 HYDROCHLORIDERelated Search:

TYRPHOSTIN AG 879 ZM 336372 AAL-993 ZM 447439 MMP-2/MMP-9 INHIBITOR IV ISOBAVACHALCONE MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 Doxycycline hyclate MCA-PRO-LEU-ALA-NVA-DAP(DNP)-ALA-ARG-NH2 Ilomastat AcetaMide, N-hydroxy-2-[[(4-Methoxyphenyl)sulfonyl](2-Methylpropyl)aMino]- (R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID OTAVA-BB 1138073 CL 82198 HYDROCHLORIDE

CL 82198 HYDROCHLORIDE

N-[4-(4-MORPHOLINYL)BUTYL]-2-BENZOFURANCARBOXAMIDE HYDROCHLORIDE

N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide

N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide,hydrochloride

N-(4-Morpholinobutyl)benzofuran-2-carboxamide hydrochloride

Benzofuran-2-carboxylic acid (4-morpholin-4-yl-butyl)-amide

CL-82198 (CL82198

2-Benzofurancarboxamide, N-[4-(4-morpholinyl)butyl]-

CL 82198 hydrochlori

N-(4-Morpholinobutyl)benzofuran-2-carboxamide

Inhibitor,CL-82198,CL82198,MMP,inhibit,Matrix metalloproteinases,CL 82198

307002-71-7

C17H33N2O3HCl

Protease inhibitor

Angiogenesis and Metastasis