CL 82198 HYDROCHLORIDE
- Product Name
- CL 82198 HYDROCHLORIDE
- CAS No.
- 307002-71-7
- Chemical Name
- CL 82198 HYDROCHLORIDE
- Synonyms
- CL-82198 (CL82198;CL 82198 hydrochlori;CL 82198 HYDROCHLORIDE;N-(4-Morpholinobutyl)benzofuran-2-carboxamide;N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide;2-Benzofurancarboxamide, N-[4-(4-morpholinyl)butyl]-;Benzofuran-2-carboxylic acid (4-morpholin-4-yl-butyl)-amide;N-(4-Morpholinobutyl)benzofuran-2-carboxamide hydrochloride;N-[4-(4-MORPHOLINYL)BUTYL]-2-BENZOFURANCARBOXAMIDE HYDROCHLORIDE;N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide,hydrochloride
- CBNumber
- CB42450342
- Molecular Formula
- C17H22N2O3
- Formula Weight
- 302.37
- MOL File
- 307002-71-7.mol
CL 82198 HYDROCHLORIDE Property
- Boiling point:
- 515.6±40.0 °C(Predicted)
- Density
- 1.159±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- powder
- pka
- 14.19±0.46(Predicted)
- color
- white to off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C9498
- Product name
- CL-82198
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- C9498
- Product name
- CL-82198
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $371
- Updated
- 2024/03/01
- Product number
- 16928
- Product name
- CL-82198
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16928
- Product name
- CL-82198
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 16928
- Product name
- CL-82198
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $270
- Updated
- 2024/03/01
CL 82198 HYDROCHLORIDE Chemical Properties,Usage,Production
Description
CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 μg/ml. It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme. CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.
Uses
CL-82198 is a selective inhibitor of human collagenase-3, known as matrix metalloproteinase-13.
Biological Activity
Selective inhibitor of MMP-13 (89% inhibition at 10 μ g/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.
Biochem/physiol Actions
CL-82198 is a selective inhibitor of MMP-13 that displays no activity at MMP-1, MMP-9 or TACE. It is also a selective S1′ pocket binder, binding within the entire S1′ pocket of MMP-13, docking with the morpholine ring adjacent to the catalytic zinc atom without zinc chelation.
in vitro
cl-82198 was identified as a weak inhibitor against mmp-13 and demonstrated no activity against mmp-1, mmp-9, or the related enzyme tace. bearing drug-like properties, cl-82198 was regarded as an ideal candidate for optimization of enzyme potency and selectivity. in nmr binding studies, it was shown that cl-82198 bound within the entire s1’ pocket of mmp-13, which was the basis of its selectivity against mmp-1, mmp-9, and tace [1].
in vivo
to investigate the contribution of mmp-13 down-regulation during gastroprotection by acetaminophen, the effects of cl-82198 on ibp-induced gastric damage were evaluated. results showed that cl-82198 decreased gastric lesions in a dose-dependent manner in the presence of ibp. compared with ibp administration alone, cl-82198 administered at 0.2 and 1.0 mg/kg resulted in 40.3% and 72.1% decrease in gastric lesion, respectively [1].
IC 50
89% inhibition at 10μg/ml
References
1) Chen, et al. (2000), Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design; J. Am. Chem. Soc., 122 9648
CL 82198 HYDROCHLORIDE Preparation Products And Raw materials
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