MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2

Product Name: MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2
CAS No.: 720710-69-0
Chemical Name: MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2
Synonyms: (Dnp)-Ala-Arg-NH2;Mca-KPLGL-Dap(Dnp)-AR-NH2;MMPs substrate Fluorogenic;MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2;MOCAC-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2;MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2;Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2Trifluoroacetate salt;N2-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-lysyl-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-L-argininamide;L-Argininamide, N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-lysyl-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-
CBNumber: CB6154741
Molecular Formula: C55H80N16O16
Formula Weight: 1221.32
MOL File: 720710-69-0.mol

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MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 Property

form: Lyophilized yellow solid.
color: Light yellow to yellow
Appearance: Lyophilized Yellow Solid
Sequence: {Mca}-Lys-Pro-Leu-Gly-Leu-{Dap(Dnp)}-Ala-Arg-NH2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0010279
Product name: MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2
Purity: 95.00%
Packaging: 5MG
Price: $504.71
Updated: 2021/12/16

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MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 Chemical Properties,Usage,Production

Description

Mca-KPLGL-Dpa-AR-NH2 is an N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH2 with a Lys yields a fluorogenic peptide with improved substrate properties. Compared with Mca-PLGL-Dpa-AR-NH2, the specificity constant (kcat/Km) of the broad-spectrum MMP-substrate Mca-KPLGL-Dpa-AR-NH2 for collagenases (MMP-1, MMP-8, MMP-13) and MMP-14 is increased by 2-9 times and 3 times, respectively, while those for gelatinases and matrilysin remain equally high.

Uses

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1[1]. (Ex/Em=325 nm/400 nm)

IC 50

MMP-1: 27.5 μM (Km); MMP-8; MMP-13: 5.2 μM (Km); MMP-14: 7.9 μM (Km)

References

[1] Neumann U, et al. Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme. Anal Biochem. 2004 May 15;328(2):166-73. DOI:10.1016/j.ab.2003.12.035

Sequene

Mca-KPLGL-Dpa-AR-NH2

MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 Suppliers

China 35 United States 3 Global 38

GL Biochem (Shanghai) Ltd

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Nanjing chengqimei Biotechnology Co., Ltd

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720710-69-0, MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2Related Search:

MMP-2/MMP-9 INHIBITOR IV ISOBAVACHALCONE Doxycycline hyclate MCA-PRO-LEU-ALA-NVA-DAP(DNP)-ALA-ARG-NH2 CL 82198 HYDROCHLORIDE Ilomastat AcetaMide, N-hydroxy-2-[[(4-Methoxyphenyl)sulfonyl](2-Methylpropyl)aMino]- (R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 (7-METHOXYCOUMARIN-4-YL)ACETYL-L-LYSYL-L-PROLYL-L-LEUCYLGLYCYL-L-LEUCYL-[N-BETA-(2,4-DINITROPHENYL)-L-2,3-DIAMINOPROPIONYL]-L-ALANYL-L-ARGININE AMIDE TRIFLUOROACETATE

MCA-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2

MOCAC-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2

Mca-KPLGL-Dap(Dnp)-AR-NH2

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2Trifluoroacetate salt

L-Argininamide, N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-lysyl-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-

N2-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-lysyl-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-L-argininamide

MMPs substrate Fluorogenic

(Dnp)-Ala-Arg-NH2

MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2

720710-69-0

C55H80N16O16