ChemicalBook > CAS DataBase List > Wnt-C59

Wnt-C59

Product Name
Wnt-C59
CAS No.
1243243-89-1
Chemical Name
Wnt-C59
Synonyms
C59;CS-876;Wnt-C59;Wnt-C59 (C59);Wnt-C59, >=98%;Wnt-C59 USP/EP/BP;WNT C59; C59;WNTC59;WNT-C59 (C59);WNT C59;C59;Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem;Wnt-C59, 98%, a potent PORCN enzymatic activity and Wnt inhibitor
CBNumber
CB62645245
Molecular Formula
C25H21N3O
Formula Weight
379.45
MOL File
1243243-89-1.mol
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Wnt-C59 Property

Melting point:
>159°C (dec.)
Boiling point:
628.3±55.0 °C(Predicted)
Density 
1.198±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
form 
Off-white powder
pka
13.78±0.70(Predicted)
color 
Tan
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.00496
Product name
Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem
Packaging
10MG
Price
$191
Updated
2024/03/01
Cayman Chemical
Product number
16644
Product name
Wnt-C59
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16644
Product name
Wnt-C59
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
16644
Product name
Wnt-C59
Purity
≥98%
Packaging
10mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
16644
Product name
Wnt-C59
Purity
≥98%
Packaging
50mg
Price
$723
Updated
2024/03/01
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Wnt-C59 Chemical Properties,Usage,Production

Description

Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2? Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3? Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4

Uses

Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.

storage

-20°C

References

1) Proffitt et al. (2013), Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of Wnt-Driven Mammary Cancer; Cancer Res., 73 502 2) Koo et al. (2015), Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia; Proc. Natl. Acad. Sci.USA, 112 7548 3) Motono et al. (2016), Wnt-C59, a Small-Molecule Wnt Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells; Stem Cells Transl.Med., 5 552 4) Madan et al. (2016), Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis; Kidney Int., 89 1062

Wnt-C59 Preparation Products And Raw materials

Raw materials

Preparation Products

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Wnt-C59 Suppliers

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1243243-89-1, Wnt-C59Related Search:

2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine WY-14643 WWL229 Wnt Agonist WS3 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenylbutane-1,4-dione Thiazovivin Y27632 (hydrochloride) xav-939 Sunitinib Malate CHIR-99021 PLX4032 WNT2 / IRP Antibody LS-C393214 WNT-3a, Human Recombinant Wnt5a Antibody Wnt-2b (C-2) Alexa Fluor? 488 Wnt-16 (B-4) Wnt-3a (3A6)

  • Wnt-C59
  • 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetaMide
  • C59
  • Wnt-C59 (C59)
  • 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide
  • 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide Wnt-c59
  • Wnt-C59, >=98%
  • WNT-C59 (C59);WNT C59;C59
  • 2-[4-(2-Methyl-4-pyridyl)phenyl]-N-[4-(3-pyridyl)phenyl]acetamide
  • Wnt-C59, 98%, a potent PORCN enzymatic activity and Wnt inhibitor
  • CS-876
  • WNT C59; C59;WNTC59
  • Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem
  • Benzeneacetamide, 4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]-
  • Wnt-C59 USP/EP/BP
  • 1243243-89-1
  • Inhibitors
  • API