2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine
- Product Name
- 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine
- CAS No.
- 2055397-28-7
- Chemical Name
- 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine
- Synonyms
- WM-1110;WM-1119;CS-2848;WM-1119 (WM1119;WM-1119, 10 mM in DMSO;WM-1119;WM 1119;WM1119;KAT6A INHIBITOR; KAT6B INHIBITOR;3-fluoro-N'-(2-fluorophenyl)sulfonyl-5-pyridin-2-ylbenzohydrazide;2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine;Histone Acetyltransferase,HATs,HAT,Inhibitor,WM 1119,inhibit,WM-1119;2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
- CBNumber
- CB94660414
- Molecular Formula
- C18H13F2N3O3S
- Formula Weight
- 389.38
- MOL File
- 2055397-28-7.mol
2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Property
- Density
- 1.414±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:30.0(Max Conc. mg/mL);76.97(Max Conc. mM)
- form
- A crystalline solid
- pka
- 6.79±0.25(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H290May be corrosive to metals
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P390Absorb spillage to prevent material damage.
N-Bromosuccinimide Price
- Product number
- SML3067
- Product name
- WM-1119
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $96.8
- Updated
- 2025/07/31
- Product number
- SML3067
- Product name
- WM-1119
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $392
- Updated
- 2025/07/31
- Product number
- 6692
- Product name
- WM1119
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $212
- Updated
- 2021/12/16
- Product number
- 6692
- Product name
- WM1119
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $891
- Updated
- 2021/12/16
- Product number
- W499295
- Product name
- WM1119
- Packaging
- 25mg
- Price
- $825
- Updated
- 2021/12/16
2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Chemical Properties,Usage,Production
Uses
WM 1119 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.
Biological Activity
WM-1119 is a potent and selective, acetyl coenzyme A (Acetyl-CoA)-competitive inhibitor against MYST family histone acetyltransferases KAT6A and KAT6B (KAT6B Kd = 2.1 nM by SPR, IC50 = 37 nM by activity assay; KAT7/5 Kd = 0.53/2.2 μM; no affinity toward 159 diverse biological targets). WM-1119 induces MEF G1 cell cycle arrest (1-10 μM), inhibits EMRK1184 lymphoma growth in cultures (IC50 = 250 nM) and in mice in vivo (50 mg/kg 3x or 4x i.p. per day).
in vivo
By day 14, the cohorts that are treated four times per day with WM-1119 have arrested tumour growth, with the exception of one mouse that does not respond. Spleen weights in the WM-1119-treatment group (treated four times per day) are substantially lower than spleen weights in the vehicle-treated group. Treatment with WM-1119 three times per day leads to a significant reduction in tumour burden and spleen weight, but is not as effective as treatment four times per day. WM-1119 is well-tolerated; mice show no generalized ill effects and weight loss is not observed. The proportion and overall number of tumour cells is substantially reduced by WM-1119 treatment (four times per day)[1].
IC 50
MOZ/MORF
storage
Store at +4°C
2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Preparation Products And Raw materials
Raw materials
Preparation Products
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