ChemicalBook > CAS DataBase List > MOZ-IN-3
MOZ-IN-3
- Product Name
- MOZ-IN-3
- CAS No.
- 2055397-18-5
- Chemical Name
- MOZ-IN-3
- Synonyms
- MOZ-IN-3;KAT6B inhibitor;KAT6A inhibitor;MOZ-IN-3/WM-8014;WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR;N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide;N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide;WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014;1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide;[1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide
- CBNumber
- CB03376843
- Molecular Formula
- C20H17FN2O3S
- Formula Weight
- 384.42
- MOL File
- 2055397-18-5.mol
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MOZ-IN-3 Property
- Density
- 1.307±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml; DMSO: 33 mg/ml; Ethanol: 2 mg/ml
- form
- A crystalline solid
- pka
- 7.15±0.25(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 27402
- Product name
- MOZ-IN-3
- Packaging
- 1mg
- Price
- $65
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27402
- Product name
- MOZ-IN-3
- Packaging
- 5mg
- Price
- $178
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27402
- Product name
- MOZ-IN-3
- Packaging
- 500μg
- Price
- $37
- Updated
- 2024/03/01
TRC
- Product number
- M732725
- Product name
- MOZ-IN-3
- Packaging
- 25mg
- Price
- $1100
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0022886
- Product name
- WM-8014
- Purity
- 99.64%
- Packaging
- 25mg
- Price
- $1100
- Updated
- 2021/12/16
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MOZ-IN-3 Chemical Properties,Usage,Production
Description
MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 μM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 μM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 μM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.
Uses
MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.
storage
Store at -20°C
MOZ-IN-3 Preparation Products And Raw materials
Raw materials
Preparation Products
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MOZ-IN-3 Suppliers
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- 021-52996696，15000506266 15000506266
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- +86-21-52996696
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- China
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