WM-3835

Product Name: WM-3835
CAS No.: 2229025-70-9
Chemical Name: WM-3835
Synonyms: WM-3835;WM-3835, 10 mM in DMSO;N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide;[1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-[(3-hydroxyphenyl)sulfonyl]hydrazide;invasion,MYST2,HBO1,WM3835,MYLK-HOXA9,Histone Acetyltransferase,Apoptosis,inhibit,H4K12ac,HATs,KAT7,WM-3835,migration,WM 3835,acetyl-CoA,HAT,OS) cell proliferation,osteosarcoma,H3K14ac,Inhibitor,pOS-1
CBNumber: CB08368935
Molecular Formula: C20H17FN2O4S
Formula Weight: 400.42
MOL File: 2229025-70-9.mol

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WM-3835 Property

Density: 1.369±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 250 mg/mL (624.34 mM; Need ultrasonic)
pka: 7.26±0.25(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3319
Product name: WM-3835
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $146
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3319
Product name: WM-3835
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $584
Updated: 2025/07/31

Tocris

Product number: 7366
Product name: WM3835
Purity: ≥98%(HPLC)
Packaging: 10
Price: $209
Updated: 2021/12/16

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WM-3835 Chemical Properties,Usage,Production

Uses

WM-3835 is a potent and high-specific HBO1 (KAT7 or MYST2) inhibitor and binds directly to the acetyl-CoA binding site of HBO1. WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice[1].

Biological Activity

WM-3835is a cell-permeable hydroxybenzenesulfonohydrazide compound th at acts as a potent, selective, Ac-CoA competitive and reversible inhibitor of HBO1, KAT6A, and TIP60 acetyltransferases (IC50 = 0.030, 0.017 and 0.312 μM, respectively). WM-3835 is non-cytotoxic, dose-dependently, and rapidly decreases H3K14Ac levels (IC50 = 0.341 μM) and inhibits AML cells growth (IC50 = 0.297 μM in Molm13). Induces apoptosis, downregulates HOXA and IL-6 expression and up-regulates ALB secretion and delays hepatocyte and hMPC senescence. WM-1385 potently inhibits POS-1 xenograft growth in SCID mice (10 mg/kg, i.p.).

in vivo

WM-3835 (10 mg/kg/day; ip; for21 days) potently inhibits pOS-1 xenograft growth in SCID mice^[1].

Animal Model:	SCID mice (18-19 g, female) with pOS1 cells^[1]
Dosage:	10 mg/kg
Administration:	IP; daily; for 21 days
Result:	Potently inhibited pOS-1 xenograft growth.

IC 50

HBO1

storage

Store at -20°C

References

[1] Yan-Yang Gao, et al. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Theranostics. 2021 Mar 4;11(10):4599-4615. DOI:10.7150/thno.55655

WM-3835 Preparation Products And Raw materials

Raw materials

Preparation Products

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WM-3835 Suppliers

China 51 United States 4 Global 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
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Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
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Heze Development Zone chuangli Chemical Co., Ltd.

Tel: 0530-+86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
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Shanghai Yu Ben Biotechnology Co., Ltd.

Tel: 021-61350663 15502154572
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Email: 1639466865@qq.com
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2229025-70-9, WM-3835Related Search:

2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine WM-2474 MOZ-IN-3

WM-3835

invasion,MYST2,HBO1,WM3835,MYLK-HOXA9,Histone Acetyltransferase,Apoptosis,inhibit,H4K12ac,HATs,KAT7,WM-3835,migration,WM 3835,acetyl-CoA,HAT,OS) cell proliferation,osteosarcoma,H3K14ac,Inhibitor,pOS-1

N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide

[1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-[(3-hydroxyphenyl)sulfonyl]hydrazide

WM-3835, 10 mM in DMSO

2229025-70-9