MOZ-IN-3

ChemicalBook > CAS DataBase List > MOZ-IN-3

Product Name: MOZ-IN-3
CAS No.: 2055397-18-5
Chemical Name: MOZ-IN-3
Synonyms: MOZ-IN-3;KAT6B inhibitor;KAT6A inhibitor;MOZ-IN-3/WM-8014;WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR;N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide;N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide;WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014;1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide;1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide
CBNumber: CB03376843
Molecular Formula: C20H17FN2O3S
Formula Weight: 384.42
MOL File: 2055397-18-5.mol

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MOZ-IN-3 Property

Density: 1.307±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml; DMSO: 33 mg/ml; Ethanol: 2 mg/ml
form: A crystalline solid
pka: 7.15±0.25(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27402
Product name: MOZ-IN-3
Packaging: 1mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 27402
Product name: MOZ-IN-3
Packaging: 5mg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 27402
Product name: MOZ-IN-3
Packaging: 500μg
Price: $37
Updated: 2024/03/01

TRC

Product number: M732725
Product name: MOZ-IN-3
Packaging: 25mg
Price: $1100
Updated: 2021/12/16

ChemScene

Product number: CS-0022886
Product name: WM-8014
Purity: 99.64%
Packaging: 25mg
Price: $1100
Updated: 2021/12/16

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MOZ-IN-3 Chemical Properties,Usage,Production

Description

MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC₅₀s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC₅₀s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC₅₀ = 2.4 μM) and inhibits proliferation of EMRK1184 lymphoma cells (IC₅₀ = 2.3 μM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 μM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.

Uses

MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.

storage

Store at -20°C

MOZ-IN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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MOZ-IN-3 Suppliers

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2055397-18-5, MOZ-IN-3Related Search:

WM-2474 WM-3835 D18 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine

MOZ-IN-3

KAT6A inhibitor

KAT6B inhibitor

WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR

MOZ-IN-3/WM-8014

[1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide

1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide

WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014

N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide

N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide

1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide

2055397-18-5