ChemicalBook > CAS DataBase List > 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine

2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine

Product Name: 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine
CAS No.: 2055397-28-7
Chemical Name: 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine
Synonyms: WM-1110;WM-1119;CS-2848;WM-1119 (WM1119;WM-1119, 10 mM in DMSO;WM-1119;WM 1119;WM1119;KAT6A INHIBITOR; KAT6B INHIBITOR;3-fluoro-N'-(2-fluorophenyl)sulfonyl-5-pyridin-2-ylbenzohydrazide;2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine;Histone Acetyltransferase,HATs,HAT,Inhibitor,WM 1119,inhibit,WM-1119;2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
CBNumber: CB94660414
Molecular Formula: C18H13F2N3O3S
Formula Weight: 389.38
MOL File: 2055397-28-7.mol

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2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Property

Density: 1.414±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:30.0(Max Conc. mg/mL);76.97(Max Conc. mM)
form: A crystalline solid
pka: 6.79±0.25(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H290May be corrosive to metals

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P390Absorb spillage to prevent material damage.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3067
Product name: WM-1119
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $96.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3067
Product name: WM-1119
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $392
Updated: 2025/07/31

Tocris

Product number: 6692
Product name: WM1119
Purity: ≥98%(HPLC)
Packaging: 10
Price: $212
Updated: 2021/12/16

Tocris

Product number: 6692
Product name: WM1119
Purity: ≥98%(HPLC)
Packaging: 50
Price: $891
Updated: 2021/12/16

TRC

Product number: W499295
Product name: WM1119
Packaging: 25mg
Price: $825
Updated: 2021/12/16

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2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Chemical Properties,Usage,Production

Uses

WM 1119 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.

Biological Activity

WM-1119 is a potent and selective, acetyl coenzyme A (Acetyl-CoA)-competitive inhibitor against MYST family histone acetyltransferases KAT6A and KAT6B (KAT6B Kd = 2.1 nM by SPR, IC50 = 37 nM by activity assay; KAT7/5 Kd = 0.53/2.2 μM; no affinity toward 159 diverse biological targets). WM-1119 induces MEF G1 cell cycle arrest (1-10 μM), inhibits EMRK1184 lymphoma growth in cultures (IC50 = 250 nM) and in mice in vivo (50 mg/kg 3x or 4x i.p. per day).

in vivo

By day 14, the cohorts that are treated four times per day with WM-1119 have arrested tumour growth, with the exception of one mouse that does not respond. Spleen weights in the WM-1119-treatment group (treated four times per day) are substantially lower than spleen weights in the vehicle-treated group. Treatment with WM-1119 three times per day leads to a significant reduction in tumour burden and spleen weight, but is not as effective as treatment four times per day. WM-1119 is well-tolerated; mice show no generalized ill effects and weight loss is not observed. The proportion and overall number of tumour cells is substantially reduced by WM-1119 treatment (four times per day)^[1].

IC 50

MOZ/MORF

storage

Store at +4°C

2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Suppliers

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2055397-28-7, 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazineRelated Search:

WM-2474 WM-3835 Wnt-C59 Wnt Agonist MOZ-IN-3

2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine

WM-1119

WM-1110

WM-1119;WM 1119;WM1119;KAT6A INHIBITOR; KAT6B INHIBITOR

CS-2848

Benzoic acid, 3-fluoro-5-(2-pyridinyl)-, 2-[(2-fluorophenyl)sulfonyl]hydrazide

（WM-1119） 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine

Benzoic acid, 3-fluoro-5-(2-pyridinyl)-, 2-[(3-fluorophenyl)sulfonyl]hydrazide

Histone Acetyltransferase,HATs,HAT,Inhibitor,WM 1119,inhibit,WM-1119

2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide

WM-1119, 10 mM in DMSO

WM-1119 (WM1119

3-fluoro-N'-(2-fluorophenyl)sulfonyl-5-pyridin-2-ylbenzohydrazide

2055397-28-7

API