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6-chloro-Nmethylpyrimidin-4-amine

Product Name
6-chloro-Nmethylpyrimidin-4-amine
CAS No.
65766-32-7
Chemical Name
6-chloro-Nmethylpyrimidin-4-amine
Synonyms
EOS-60926;4-Chloro-6-methylaminopyrimidine;6-chloro-Nmethylpyrimidin-4-amine;4-Pyrimidinamine, 6-chloro-N-methyl-;4-Pyrimidinamine, 6-chloro-N-methyl- (9CI);6-chloro-Nmethylpyrimidin-4-amine ISO 9001：2015 REACH
CBNumber
CB9970924
Molecular Formula
C5H6ClN3
Formula Weight
143.57
MOL File
65766-32-7.mol
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6-chloro-Nmethylpyrimidin-4-amine Property

Melting point:
138-142°C
Boiling point:
279.7±20.0 °C(Predicted)
Density 
1.338±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
2.50±0.10(Predicted)
form 
solid
Appearance
White to off-white Solid
InChI
InChI=1S/C5H6ClN3/c1-7-5-2-4(6)8-3-9-5/h2-3H,1H3,(H,7,8,9)
InChIKey
WZVLJUBTIWFTIE-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=CC(NC)=N1
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-43
Safety Statements 
26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
732087
Product name
4-Chloro-6-(methylamino)pyrimidine
Purity
97%
Packaging
1g
Price
$74.5
Updated
2023/06/20
TRC
Product number
C349785
Product name
4-Chloro-6-methylaminopyrimidine
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
C349785
Product name
4-Chloro-6-methylaminopyrimidine
Packaging
100mg
Price
$45
Updated
2021/12/16
BroadPharm
Product number
BP-11536
Product name
6-chloro-N-methylpyrimidin-4-amine
Packaging
1g
Price
$58
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC139833
Product name
6-Chloro-N-methylpyrimidin-4-amine
Packaging
1g
Price
$65
Updated
2021/12/16
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6-chloro-Nmethylpyrimidin-4-amine Chemical Properties,Usage,Production

Synthesis

1193-21-1

593-51-1

65766-32-7

General procedure for the synthesis of 6-chloro-N-methyl-4-aminopyrimidine from 4,6-dichloropyrimidine and methylamine hydrochloride: in a 100 mL round-bottomed flask N,N-dimethylformamide (10 mL), 4,6-dichloropyrimidine (1 g, 6.71 mmol, 1.0 equiv.), cesium carbonate (4.4 g, 13.50 mmol, 2.01 equiv.) and methylamine hydrochloride (905 mg, 13.40 mmol, 2.00 eq.). The reaction mixture was stirred at 80 °C for 14 hours. After completion of the reaction, the reaction solution was diluted with 10 mL of water and extracted with ethyl acetate (4 x 10 mL). The organic layers were combined and washed once with 10 mL of water. The organic phase was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:1) as eluent. 750 mg (78% yield) of the target product 6-chloro-N-methyl-4-aminopyrimidine was finally obtained as a white solid. The product was analyzed by LC-MS to confirm: (ES, m/z): retention time RT = 0.476 min, LCMS 32: m/z = 144 [M + 1].

References

[1] European Journal of Organic Chemistry, 2014, vol. 2014, # 7, p. 1514 - 1524
[2] European Journal of Organic Chemistry, 2014, vol. 2014, # 7, p. 1514 - 1524
[3] Patent: WO2017/181177, 2017, A1. Location in patent: Paragraph 0950-0953
[4] Tetrahedron, 2007, vol. 63, # 25, p. 5394 - 5405

6-chloro-Nmethylpyrimidin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-chloro-Nmethylpyrimidin-4-amine Suppliers

China 134 Europe 1 Germany 1 India 2 United Kingdom 2 United States 12 Global 152
Beijing Bosennuokang Pharmaceutical Technology Co., Ltd.
Tel
010-86203349 18201082367
Email
bosennuokang@163.com
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China
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
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China
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Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
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sales@chemwish.com
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China
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
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China
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Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
Tel
21-57721279
Fax
QQ：14057904
Email
sales@shydchem.com.cn
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China
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998
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Tetranov Biopharm
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13526569071
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sales@leadmedpharm.com
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China
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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sales@accelachem.com
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China
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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Syntechem Co.,Ltd
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Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
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12984
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View Lastest Price from 6-chloro-Nmethylpyrimidin-4-amine manufacturers

Dideu Industries Group Limited
Product
6-chloro-Nmethylpyrimidin-4-amine 65766-32-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-13
Career Henan Chemical Co
Product
6-chloro-Nmethylpyrimidin-4-amine 65766-32-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2019-12-30

65766-32-7, 6-chloro-Nmethylpyrimidin-4-amineRelated Search:

WY-14643 4-CHLORO-2,6-DIPYRROLIDIN-1-YLPYRIMIDINE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-METHYLBENZAMIDE N4-benzyl-6-chloropyrimidine-4,5-diamine 4-(m-aminoanilino)-2,5,6-trichloropyrimidine N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE N-PHENYL-N'-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)UREA N-(4-CHLOROPHENYL)-N'-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)UREA 7-(4-TERT-BUTYLPHENYL)-4-CHLORO-6,7-DIHYDRO-2-(METHYLTHIO)-(5H)-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-7-(3,5-DIMETHYLPHENYL)-6,7-DIHYDRO-2-(METHYLTHIO)-(5H)-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-7-CYCLOHEXYL-6,7-DIHYDRO-2-(METHYLTHIO)-(5H)-PYRROLO[2,3-D]PYRIMIDINE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-(TRIFLUOROMETHYL)BENZENE-1-SULFONAMIDE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-CHLOROBENZENE-1-SULFONAMIDE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-FLUOROBENZAMIDE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-METHYLBENZENE-1-SULFONAMIDE 4-CHLORO-2-METHYLSULFANYL-6-PHENYLAMINO-PYRIMIDINE-5-CARBONITRILE 4-CHLORO-6,7-DIHYDRO-7-(4-METHOXYPHENYL)-2-(METHYLTHIO)-(5H)-PYRROLO[2,3-D]PYRIMIDINE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-3-(TRIFLUOROMETHYL)BENZAMIDE

  • 6-chloro-Nmethylpyrimidin-4-amine
  • 4-Pyrimidinamine, 6-chloro-N-methyl- (9CI)
  • 4-Chloro-6-methylaminopyrimidine
  • EOS-60926
  • 4-Pyrimidinamine, 6-chloro-N-methyl-
  • 6-chloro-Nmethylpyrimidin-4-amine ISO 9001：2015 REACH
  • 65766-32-7
  • amine|alkyl chloride
  • Amines
  • PYRIMIDINE
  • blocks
  • APIs & Intermediate