6-CHLORO-5-NITROPYRIMIDIN-4-AMINE

Product Name: 6-CHLORO-5-NITROPYRIMIDIN-4-AMINE
CAS No.: 4316-94-3
Chemical Name: 6-CHLORO-5-NITROPYRIMIDIN-4-AMINE
Synonyms: NSC 401941;AKOS A0602-0633;AKOS BBS-00002074;IFLAB-BB F1386-0156;6-Chloro-5-nitro-4-pyrimidinamine;6-CHLORO-5-NITROPYRIMIDIN-4-AMINE;4-AMino-5-nitro-6-chloropyriMidine;4-Amino-6-chloro-5-nitropyrimidine;4-Chloro-5-nitro-6-pyrimidinylamine;4-PyriMidinaMine, 6-chloro-5-nitro-
CBNumber: CB0389488
Molecular Formula: C4H3ClN4O2
Formula Weight: 174.55
MOL File: 4316-94-3.mol

More

Less

6-CHLORO-5-NITROPYRIMIDIN-4-AMINE Property

Melting point:: 155-156 °C
Boiling point:: 394.7±37.0 °C(Predicted)
Density: 1.712±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -1.07±0.10(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C4H3ClN4O2/c5-3-2(9(10)11)4(6)8-1-7-3/h1H,(H2,6,7,8)
InChIKey: BWLOHIMQWHFSQF-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C([N+]([O-])=O)C(N)=N1

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: C350250
Product name: 6-Chloro-5-nitropyrimidin-4-amine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144258
Product name: 6-Chloro-5-nitropyrimidin-4-amine
Packaging: 250mg
Price: $62.5
Updated: 2021/12/16

Matrix Scientific

Product number: 072584
Product name: 6-Chloro-5-nitropyrimidin-4-amine
Purity: 95+%
Packaging: 1g
Price: $94
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144258
Product name: 6-Chloro-5-nitropyrimidin-4-amine
Packaging: 500mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: J50904
Product name: 6-Chloro-5-nitropyrimidin-4-amine
Packaging: 5g
Price: $165
Updated: 2021/12/16

More

Less

6-CHLORO-5-NITROPYRIMIDIN-4-AMINE Chemical Properties,Usage,Production

Uses

6-Chloro-5-nitropyrimidin-4-amine is a substituted pyrimidine with antifungal properties.

Synthesis

4316-93-2

4316-94-3

4,6-Dichloro-5-nitropyrimidine (9.7 g, 50 mmol) was used as starting material and dissolved in tetrahydrofuran (100 mL). To this solution ammonia (100 mL) and sodium bicarbonate (4.6 g, 55 mmol) were added sequentially. The reaction mixture was heated to 55°C and stirred at this temperature overnight. Upon completion of the reaction, the mixture was cooled to room temperature and the organic solvent was subsequently evaporated under reduced pressure. The residue was filtered and purified by fast column chromatography (eluent ratio of dichloromethane: methanol = 100:1) to give the final target product 4-amino-6-chloro-5-nitropyrimidine (6-chloro-5-nitropyrimidin-4-amine, 8.1 g, 93% yield).

References

[1] Patent: CN106146504, 2016, A. Location in patent: Paragraph 0136; 0137; 0138; 0139; 0140
[2] Journal of Organic Chemistry, 1959, vol. 24, p. 1314,1315
[3] Journal of the Chemical Society, 1951, p. 96,99
[4] Journal of Medicinal and Pharmaceutical Chemistry, 1959, vol. 1, p. 371,376,377
[5] Tetrahedron, 2002, vol. 58, # 38, p. 7607 - 7611

6-CHLORO-5-NITROPYRIMIDIN-4-AMINE Preparation Products And Raw materials

Raw materials

Toluene 4,6-Dihydroxypyrimidine N,N-Diisopropylethylamine Trifluoroacetic acid Phosphorus oxitrichloride 1,4-Dioxane Phosphorus trichloride Tetrahydrofuran Sodium bicarbonate Nitric acid Ammonium acetate

Preparation Products

More

Less

6-CHLORO-5-NITROPYRIMIDIN-4-AMINE Suppliers

Canada 1 China 69 Germany 2 India 1 United Kingdom 2 United States 6 Global 81

Shanghai Zhenzhi Pharmaceutical Technology Co., Ltd

Tel: 15262370735
Email: 404840704@qq.com
Country: China
ProdList: 109
Advantage: 58

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5000
Advantage: 55

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Wuhan ariel chemical Co., LTD.

Tel: 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3763
Advantage: 58

Chiba Pharmaceutical Science and technology Co, Ltd.

Tel: 0531-81313138 13066006660
Fax: QQ: 3366077777
Email: chibapharm@foxmail.com
Country: China
ProdList: 3991
Advantage: 55

NovoChemy Ltd.

Tel: 021-31261262/ 49 (0)17662837245
Fax: (0)21-33250524
Email: sales@novochemy.com
Country: Germany
ProdList: 6328
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai Keepontech Co.,Ltd

Tel: 021-54849683 13601642561
Fax: +86-21-54375689
Email: sales@keepontech.com
Country: China
ProdList: 998
Advantage: 59

More

Less

View Lastest Price from 6-CHLORO-5-NITROPYRIMIDIN-4-AMINE manufacturers

Jiangsu Liyang Kunlun Biological Technology Co., Ltd.

Product: 6-CHLORO-5-NITROPYRIMIDIN-4-AMINE 4316-94-3
Price: US $0.00/kg
Min. Order: 100kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2025-03-16

Shaanxi Dideu Medichem Co. Ltd

Product: 6-Chloro-5-nitropyrimidin-4-amine 4316-94-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 6-CHLORO-5-NITROPYRIMIDIN-4-AMINE 4316-94-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

4316-94-3, 6-CHLORO-5-NITROPYRIMIDIN-4-AMINERelated Search:

6-CHLORO-5-NITROPYRIMIDIN-4-AMINE 2-Chloro-5-nitropyrimidin-4-amine ,95%,2-CHLORO-5-NITROPYRIMIDIN-4-AMINE N-benzyl-6-chloro-5-nitro-4-pyrimidinamine IFLAB-BB F2124-0139 1-(6-CHLORO-5-NITRO-4-PYRIMIDINYL)-1,2,3,4-TETRAHYDROQUINOLINE N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE IFLAB-BB F2124-0130 IFLAB-BB F2124-0125 4-CHLORO-6-(4-METHYL-1-PIPERAZINYL)-5-NITROPYRIMIDINE 6-CHLORO-5-NITROPYRIMIDINE-2,4-DIAMINE IFLAB-BB F2124-0138 IFLAB-BB F2124-0140 IFLAB-BB F2124-0124 4-CHLORO-5-NITRO-6-(1-PYRROLIDINYL)PYRIMIDINE IFLAB-BB F2124-0129 6-Chloro-5-nitropyrimidin-4-amine ,95% 4-chloro-5-nitro-6-(4-pyridin-2-ylpiperazin-1-yl)pyrimidine AKOS BBS-00003139

AKOS BBS-00002074

6-CHLORO-5-NITROPYRIMIDIN-4-AMINE

IFLAB-BB F1386-0156

AKOS A0602-0633

(6-chloro-5-nitro-pyrimidin-4-yl)amine

4-AMino-5-nitro-6-chloropyriMidine

4-PyriMidinaMine, 6-chloro-5-nitro-

4-Amino-6-chloro-5-nitropyrimidine

4-Chloro-5-nitro-6-pyrimidinylamine

6-Chloro-5-nitro-4-pyrimidinamine

NSC 401941

(6-Chloro-5-nitro-pyrimidin-4-yl)-methyl-amine

4316-94-3