2-CHLORO-5-NITROPYRIMIDIN-4-AMINE

Product Name: 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
CAS No.: 1920-66-7
Chemical Name: 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
Synonyms: KML-51;IFLAB-BB F1930-0037;nitropyrimidin-1-(2-prop-2-enoxyethoxy)butane;2-CHLORO-5-NITROPYRIMIDIN-4-AMINE;2-CHLORO-5-NITRO-4-PYRIMIDINAMINE;2-Chloro-5-nitropirimidin-4-amine;4-AMINO-2-CHLORO-5-NITROPYRIMIDINE;2-Chloro-5-nitropyrimidine-4-amine;2-Chloro-5-nitro-6-aminopyrimidine
CBNumber: CB5468616
Molecular Formula: C4H3ClN4O2
Formula Weight: 174.55
MOL File: 1920-66-7.mol

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2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Property

Melting point:: 221-226 °C
Boiling point:: 446.0±25.0 °C(Predicted)
Density: 1.712±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -1.22±0.10(Predicted)
form: Solid
Appearance: Light yellow to yellow Solid
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C4H3ClN4O2/c5-4-7-1-2(9(10)11)3(6)8-4/h1H,(H2,6,7,8)
InChIKey: RZGOEIWDMVQJBQ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C([N+]([O-])=O)C(N)=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37-36
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 720321
Product name: 4-Amino-2-chloro-5-nitropyrimidine
Purity: 95%
Packaging: 1g
Price: $211
Updated: 2023/01/07

Sigma-Aldrich

Product number: 720321
Product name: 4-Amino-2-chloro-5-nitropyrimidine
Purity: 95%
Packaging: 250mg
Price: $74
Updated: 2022/05/15

TRC

Product number: C350245
Product name: 2-Chloro-5-nitropyrimidin-4-amine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C350245
Product name: 2-Chloro-5-nitropyrimidin-4-amine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: C350245
Product name: 2-Chloro-5-nitropyrimidin-4-amine
Packaging: 500mg
Price: $90
Updated: 2021/12/16

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2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Chemical Properties,Usage,Production

Chemical Properties

Yellow to brown solid

Uses

It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Synthesis

49845-33-2

1920-66-7

General procedure for the synthesis of 2-chloro-4-amino-5-nitropyrimidines from 2,4-dichloro-5-nitropyrimidines: a solution of 2,4-dichloro-5-nitropyrimidines (30 g, 154.36 mmol) was slowly added dropwise to a solution of 2,4-dichloro-5-nitropyrimidines (30 g, 154.36 mmol) in dichloromethane (DCM) with ammonia (NH3-H2O, aqueous solution, 24 mL) and N,N-diisopropylethylamine ( DIPEA, 37.2 mL) to a mixed solution of DCM (400 mL). The reaction mixture was stirred continuously at 0 °C for 1 h, followed by filtration. The collected solid was dried to give the target product 2-chloro-4-amino-5-nitropyrimidine (25 g, 92.6% yield) as a yellow solid. It was analyzed by liquid chromatography-mass spectrometry (LCMS, ESI) and m/z: 175.0 ([M+H]+) was measured.

References

[1] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0541-0542
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10685 - 10699
[3] Patent: EP2578584, 2013, A1. Location in patent: Paragraph 0071; 0072
[4] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 2, p. 321 - 328
[5] Patent: EP3284743, 2018, A1. Location in patent: Paragraph 0135

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Preparation Products And Raw materials

Raw materials

5-Nitrouracil Ammonium hydroxide Phosphorus oxitrichloride Phosphorus trichloride Nitric acid Uracil N,N-Diethylaniline Ammonia

Preparation Products

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2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Suppliers

Canada 2 China 118 India 1 United Kingdom 4 United States 15 Global 140

Fuyang JSK Biomedical Technology Co., Ltd

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J & K SCIENTIFIC LTD.

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Nanjing Chemlin Chemical Co., Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

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View Lastest Price from 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE manufacturers

Dideu Industries Group Limited

Product: 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 1920-66-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-14

Career Henan Chemical Co

Product: 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 1920-66-7
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

1920-66-7, 2-CHLORO-5-NITROPYRIMIDIN-4-AMINERelated Search:

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 6-CHLORO-5-NITROPYRIMIDIN-4-AMINE 2-Chloro-5-nitropyrimidine 2-chloro-N-methyl-5-nitropyrimidin-4-amine 4-AMINO-2-CHLORO-6-METHYL-5-NITROPYRIMIDINE N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE 6-Chloro-5-nitropyrimidin-4-amine ,95% IFLAB-BB F2124-0162 N4,6-DIMETHYL-N4-PHENYL-2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 4-AMINO-2-CHLORO-5-NITRO-6-PIPERIDIN-1-YLPYRIMIDINE IFLAB-BB F2124-0143 CHEMBRDG-BB 5145935 2-CHLORO-5-NITRO-4-METHYL-6-(METHYLAMINO)PYRIMIDINE IFLAB-BB F2124-0156 IFLAB-BB F2124-0157 IFLAB-BB F2124-0161 4-(6-Amino-2-chloro-5-nitro-4-pyrimidinyl)morpholine IFLAB-BB F2124-0144

IFLAB-BB F1930-0037

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE

4-AMINO-2-CHLORO-5-NITROPYRIMIDINE

2-CHLORO-5-NITRO-4-PYRIMIDINAMINE

4-Pyrimidinamine, 2-chloro-5-nitro-

2-Chloro-5-nitropyrimidin-4-amine ,95%

2-Chloro-5-nitro-6-aminopyrimidine

2-Chloro-5-nitropyrimidine-4-amine

(2-chloro-5-nitro-pyrimidin-4-yl)amine

4-amino-5-nitro-2-chloropyrimidine

2-Chloro-4-aMino-5-nitropyriMidine

2-chloro-5-nitropyriMidine-4-aMino

1-(2-prop-2-enoxyethoxy)butane

2-Chloro-5-nitropirimidin-4-amine

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE ISO 9001：2015 REACH

KML-51

nitropyrimidin-&#8203

1920-66-7

20-66-7

C4H3ClN4O2

pharmacetical