4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE

Product Name: 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
CAS No.: 4316-98-7
Chemical Name: 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
Synonyms: 6-Chloropyrimidine-4,5-diamine;100063;NSC 36907;4,5-DiaMino-6-chloropyriMidine;6-Chloro-4,5-diaminopyrimidine;6-Chloro-4,5-pyrimidinediamine;5 6-DIAMINO-4-CHLOROPYRIMIDINE;4-CHLORO-5,6-DIAMINOPYRIMIDINE;4-ChloropyriMidine-5,6-diaMine;4,5-Pyrimidinediamine, 6-chloro-
CBNumber: CB1131244
Molecular Formula: C4H5ClN4
Formula Weight: 144.56
MOL File: 4316-98-7.mol

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4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Property

Melting point:: 252 °C (decomp)
Boiling point:: 336.7±37.0 °C(Predicted)
Density: 1.565
Flash point:: 157℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Sparingly), Methanol (Slightly)
form: powder to crystal
pka: 2.39±0.10(Predicted)
color: White to Amber to Dark green
λmax: 305nm(lit.)
Stability:: Hygroscopic
InChI: InChI=1S/C4H5ClN4/c5-3-2(6)4(7)9-1-8-3/h1H,6H2,(H2,7,8,9)
InChIKey: VNSFICAUILKARD-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C(N)C(N)=N1
CAS DataBase Reference: 4316-98-7
EPA Substance Registry System: 4,5-Pyrimidinediamine, 6-chloro- (4316-98-7)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3433
Product name: 6-Chloropyrimidine-4,5-diamine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $89
Updated: 2025/07/31

TRC

Product number: D416275
Product name: 4,5-Diamino-6-chloropyrimidine
Packaging: 2.5g
Price: $1210
Updated: 2021/12/16

Matrix Scientific

Product number: 071118
Product name: 4-Amino-6-chloropyrimidin-5-ylamine
Purity: 97%
Packaging: 1g
Price: $40
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21470
Product name: 4,5-Diamino-6-chloropyrimidine
Packaging: 100mg
Price: $53
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21470
Product name: 4,5-Diamino-6-chloropyrimidine
Packaging: 250mg
Price: $80
Updated: 2021/12/16

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4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

4-Amino-6-chloropyrimidin-5-ylamine is a chlorinated diaminopyrimidine used in the preparation of various bioactive choloropurine derivatives.

Synthesis

5413-85-4

4316-98-7

Step 1: 4,6-Dichloropyrimidin-5-amine (1.64 g, 10 mmol) was suspended in 5 mL of concentrated hydrochloric acid. The suspension was transferred to a sealed tube, ammonia solution was added and the reaction was stirred at 100 °C overnight. Upon completion of the reaction, the solid product was collected by filtration and dried under vacuum to afford the target compound 6-chloropyrimidine-4,5-diamine as a yellow solid (1.2 g, 83% yield).LC-MS analysis showed m/z 145 ([M+H]+).

References

[1] Patent: WO2006/46023, 2006, A1. Location in patent: Page/Page column 115-116
[2] Patent: WO2008/75110, 2008, A1. Location in patent: Page/Page column 116
[3] Patent: WO2007/125315, 2007, A2. Location in patent: Page/Page column 115
[4] Patent: WO2007/125325, 2007, A1. Location in patent: Page/Page column 92-93
[5] Organic Process Research and Development, 2011, vol. 15, # 4, p. 841 - 854

4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Preparation Products And Raw materials

Raw materials

Ammonium hydroxide 4,6-Dihydroxypyrimidine N,N-Diisopropylethylamine Nickel Trifluoroacetic acid Phosphorus oxitrichloride

Preparation Products

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4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Suppliers

Americas 1 Canada 1 China 132 Europe 2 Germany 2 India 3 Japan 1 The Netherlands 1 United Kingdom 1 United States 16 Global 160

Shanghai Xiannuo Biotechnology Co., Ltd.

Tel: 021-50718719 13918719472
Fax: 021-50718719
Country: China
ProdList: 979
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SiChuang NanBu Honesty Technology Co., Ltd.

Tel: 0838-5675166 15883665058
Fax: 0838-5675535
Email: nbcxkj@126.com
Country: China
ProdList: 918
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
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Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
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Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

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View Lastest Price from 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE manufacturers

Jiangsu Liyang Kunlun Biological Technology Co., Ltd.

Product: 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE 4316-98-7
Price: US $0.00/kg
Min. Order: 1000kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2025-03-18

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Amino-6-chloropyrimidin-5-ylamine 4316-98-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE 4316-98-7
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-24

4316-98-7, 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINERelated Search:

4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE 4-CHLORO-6-HYDRAZINO-PYRIMIDIN-5-YLAMINE 6-CHLORO-5-NITROPYRIMIDIN-4-AMINE 4-Chloro-2,6-diaminopyrimidine 2,6-Diamino-4-chloropyrimidine 1-oxide 4,5-Diaminopyrimidine IFLAB-BB F2124-0139 IFLAB-BB F2124-0138 6-CHLORO-5-NITROPYRIMIDINE-2,4-DIAMINE 4-CHLORO-6-MORPHOLIN-4-YL-PYRIMIDIN-5-YLAMINE 6-CHLORO-N4,N4-DIMETHYL-PYRIMIDINE-4,5-DIAMINE IFLAB-BB F2124-0125 4-CHLORO-6-(4-METHYL-1-PIPERAZINYL)-5-NITROPYRIMIDINE N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE 4-CHLORO-6-PIPERIDIN-1-YL-PYRIMIDIN-5-YLAMINE N4-benzyl-6-chloropyrimidine-4,5-diamine 4-CHLORO-5-NITRO-6-(1-PYRROLIDINYL)PYRIMIDINE N-benzyl-6-chloro-5-nitro-4-pyrimidinamine

4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE

4-CHLORO-5,6-DIAMINOPYRIMIDINE

5 6-DIAMINO-4-CHLOROPYRIMIDINE

4-Amino-6-chloropyrimidin-5-ylamine ,97%

6-Chloro-4,5-pyrimidinediamine

6-Chloro-4,5-diaminopyrimidine

4,5-Pyrimidinediamine, 6-chloro- (9CI)

N-(1-phenylpropan-2-yl)-4,5-dihydrooxazol-2-amine

100063

6-Chloropyrimidine-4,5-diamine

4,5-DiaMino-6-chloropyriMidine

4-ChloropyriMidine-5,6-diaMine

NSC 36907

4,5-Pyrimidinediamine, 6-chloro-

4316-98-7

Heterocycle-Pyrimidine series

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

PYRIMIDINE