ChemicalBook > CAS DataBase List > 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
- Product Name
- 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
- CAS No.
- 4316-98-7
- Chemical Name
- 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
- Synonyms
- 6-Chloropyrimidine-4,5-diamine;100063;NSC 36907;4,5-DiaMino-6-chloropyriMidine;6-Chloro-4,5-diaminopyrimidine;6-Chloro-4,5-pyrimidinediamine;5 6-DIAMINO-4-CHLOROPYRIMIDINE;4-CHLORO-5,6-DIAMINOPYRIMIDINE;4-ChloropyriMidine-5,6-diaMine;4,5-Pyrimidinediamine, 6-chloro-
- CBNumber
- CB1131244
- Molecular Formula
- C4H5ClN4
- Formula Weight
- 144.56
- MOL File
- 4316-98-7.mol
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4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Property
- Melting point:
- 252 °C (decomp)
- Boiling point:
- 336.7±37.0 °C(Predicted)
- Density
- 1.565
- Flash point:
- 157℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- powder to crystal
- pka
- 2.39±0.10(Predicted)
- color
- White to Amber to Dark green
- λmax
- 305nm(lit.)
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C4H5ClN4/c5-3-2(6)4(7)9-1-8-3/h1H,6H2,(H2,7,8,9)
- InChIKey
- VNSFICAUILKARD-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C(N)C(N)=N1
- CAS DataBase Reference
- 4316-98-7
- EPA Substance Registry System
- 4,5-Pyrimidinediamine, 6-chloro- (4316-98-7)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- C3433
- Product name
- 6-Chloropyrimidine-4,5-diamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $89
- Updated
- 2025/07/31
TRC
- Product number
- D416275
- Product name
- 4,5-Diamino-6-chloropyrimidine
- Packaging
- 2.5g
- Price
- $1210
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 071118
- Product name
- 4-Amino-6-chloropyrimidin-5-ylamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD21470
- Product name
- 4,5-Diamino-6-chloropyrimidine
- Packaging
- 100mg
- Price
- $53
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD21470
- Product name
- 4,5-Diamino-6-chloropyrimidine
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
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4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Uses
4-Amino-6-chloropyrimidin-5-ylamine is a chlorinated diaminopyrimidine used in the preparation of various bioactive choloropurine derivatives.
Synthesis
5413-85-4
4316-98-7
Step 1: 4,6-Dichloropyrimidin-5-amine (1.64 g, 10 mmol) was suspended in 5 mL of concentrated hydrochloric acid. The suspension was transferred to a sealed tube, ammonia solution was added and the reaction was stirred at 100 °C overnight. Upon completion of the reaction, the solid product was collected by filtration and dried under vacuum to afford the target compound 6-chloropyrimidine-4,5-diamine as a yellow solid (1.2 g, 83% yield).LC-MS analysis showed m/z 145 ([M+H]+).
References
[1] Patent: WO2006/46023, 2006, A1. Location in patent: Page/Page column 115-116
[2] Patent: WO2008/75110, 2008, A1. Location in patent: Page/Page column 116
[3] Patent: WO2007/125315, 2007, A2. Location in patent: Page/Page column 115
[4] Patent: WO2007/125325, 2007, A1. Location in patent: Page/Page column 92-93
[5] Organic Process Research and Development, 2011, vol. 15, # 4, p. 841 - 854
4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Preparation Products And Raw materials
Raw materials
Ammonium hydroxide
4,6-Dihydroxypyrimidine
N,N-Diisopropylethylamine
Nickel
Trifluoroacetic acid
Phosphorus oxitrichloride
Preparation Products
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View Lastest Price from 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE manufacturers
Jiangsu Liyang Kunlun Biological Technology Co., Ltd.
- Product
- 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE 4316-98-7
- Price
- US $0.00/kg
- Min. Order
- 1000kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2025-03-18
Shaanxi Dideu Medichem Co. Ltd
- Product
- 4-Amino-6-chloropyrimidin-5-ylamine 4316-98-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
Career Henan Chemical Co
- Product
- 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE 4316-98-7
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24
4316-98-7, 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINERelated Search:
4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
4-CHLORO-6-HYDRAZINO-PYRIMIDIN-5-YLAMINE
6-CHLORO-5-NITROPYRIMIDIN-4-AMINE
4-Chloro-2,6-diaminopyrimidine
2,6-Diamino-4-chloropyrimidine 1-oxide
4,5-Diaminopyrimidine
IFLAB-BB F2124-0139
IFLAB-BB F2124-0138
6-CHLORO-5-NITROPYRIMIDINE-2,4-DIAMINE
4-CHLORO-6-MORPHOLIN-4-YL-PYRIMIDIN-5-YLAMINE
6-CHLORO-N4,N4-DIMETHYL-PYRIMIDINE-4,5-DIAMINE
IFLAB-BB F2124-0125
4-CHLORO-6-(4-METHYL-1-PIPERAZINYL)-5-NITROPYRIMIDINE
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE
4-CHLORO-6-PIPERIDIN-1-YL-PYRIMIDIN-5-YLAMINE
N4-benzyl-6-chloropyrimidine-4,5-diamine
4-CHLORO-5-NITRO-6-(1-PYRROLIDINYL)PYRIMIDINE
N-benzyl-6-chloro-5-nitro-4-pyrimidinamine