4-Amino-6-chloropyrimidine
- Product Name
- 4-Amino-6-chloropyrimidine
- CAS No.
- 5305-59-9
- Chemical Name
- 4-Amino-6-chloropyrimidine
- Synonyms
- H50551;NSC 42134;4-Amino-6-chL;4-Amino-6-chloropyri;6-Chloro-4-pyrimidinamine;6-Chloropyrimidin-4-amine;6-Chloropyrimidine-4-amine;6-AMino-4-chloropyriMidine;2-CHLORO-6-AMINOPYRIMIDINE;4-AMINO-6-CHLOROPYRIMIDINE
- CBNumber
- CB4424750
- Molecular Formula
- C4H4ClN3
- Formula Weight
- 129.55
- MOL File
- 5305-59-9.mol
4-Amino-6-chloropyrimidine Property
- Melting point:
- 215-216°C
- Boiling point:
- 289.0±20.0 °C(Predicted)
- Density
- 1.437±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO
- form
- Solid
- pka
- 2.16±0.10(Predicted)
- color
- Pale Yellow
- InChI
- InChI=1S/C4H4ClN3/c5-3-1-4(6)8-2-7-3/h1-2H,(H2,6,7,8)
- InChIKey
- DUKKRSPKJMHASP-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC(N)=N1
- CAS DataBase Reference
- 5305-59-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39-36/37
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 735272
- Product name
- 4-Amino-6-chloropyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $47.9
- Updated
- 2023/06/20
- Product number
- A2136
- Product name
- 4-Amino-6-chloropyrimidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- A2136
- Product name
- 4-Amino-6-chloropyrimidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $126
- Updated
- 2025/07/31
- Product number
- A1376-61
- Product name
- 4-Amino-6-chloropyrimidine
- Packaging
- 2g
- Price
- $389
- Updated
- 2021/12/16
- Product number
- J97012
- Product name
- 4-Amino-6-chloropyrimidine
- Packaging
- 500g
- Price
- $420
- Updated
- 2021/12/16
4-Amino-6-chloropyrimidine Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Anticancer Research
4-Amino-6-chloropyrimidine has been shown to inhibit the proliferation of cancer cells in vitro and in vivo, without affecting normal cells. 4-Amino-6-chloropyrimidine also inhibits kinase activity and protein synthesis in cancer cells. This drug has a potent inhibitory effect on cell proliferation.
Synthesis
1193-21-1
5305-59-9
The general procedure for the synthesis of 4-amino-6-chloropyrimidine from 4,6-dichloropyrimidine was as follows: to a suspension of 4,6-dichloropyrimidine (3.0 g, 20 mmol) in isopropanol (40 mL) was slowly added the appropriate amine, with the rate of addition being controlled so as to maintain the internal temperature of the reaction system at no more than 40°C. The reaction mixture was stirred continuously for 1 hour at 25°C. After addition, the reaction mixture was stirred continuously at 25 °C for 1 hour. Upon completion of the reaction, water (30 mL) was added and the resulting suspension was cooled to 0 °C in an ice bath. The precipitated product was collected by filtration and washed sequentially with pre-cooled isopropanol/water solvent mixture (V/V=2:1, 50 mL) and pure water. Finally, the resulting solid product was dried under vacuum to obtain the target compound 4-amino-6-chloropyrimidine.
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 20, p. 7066 - 7083
[2] European Journal of Medicinal Chemistry, 2014, vol. 75, p. 11 - 20
[3] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 84
[4] Patent: US2012/15943, 2012, A1. Location in patent: Page/Page column 54
[5] ChemMedChem, 2017, vol. 12, # 16, p. 1390 - 1398
4-Amino-6-chloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Amino-6-chloropyrimidine Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from 4-Amino-6-chloropyrimidine manufacturers
- Product
- 4-Amino-6-chloropyrimidine 5305-59-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 4-AMino-6-chloropyriMidine 5305-59-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14
- Product
- 4-Amino-6-chloropyrimidine 5305-59-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11