Ethyl (ethoxymethylene)cyanoacetate

Product Name: Ethyl (ethoxymethylene)cyanoacetate
CAS No.: 94-05-3
Chemical Name: Ethyl (ethoxymethylene)cyanoacetate
Synonyms: ETHYL 2-CYANO-3-ETHOXYACRYLATE;ethyl (Z)-2-cyano-3-ethoxyacrylate;(E)-ethyl 2-cyano-3-ethoxyacrylate;EMCAE;Ethyl (ethoxyMethyle;2-Cyano-3-ethoxyacryL;Neratinib Impurity 52;Ethyl (ethoxymethylene);Ethyl-2-cyan-3-ethoxyacrylat;(ethoxymethylene)cyanoacetate
CBNumber: CB9758865
Molecular Formula: C8H11NO3
Formula Weight: 169.18
MOL File: 94-05-3.mol

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Ethyl (ethoxymethylene)cyanoacetate Property

Melting point:: 49-51 °C(lit.)
Boiling point:: 190-191 °C30 mm Hg(lit.)
Density: 1.2435 (rough estimate)
refractive index: 1.5100 (estimate)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, Methanol
form: Crystalline Mass or Crystals
color: White to yellow
Water Solubility: <0.01 g/L (20 ºC)
BRN: 878814
LogP: 1.376 at 25℃
CAS DataBase Reference: 94-05-3(CAS DataBase Reference)
NIST Chemistry Reference: 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester(94-05-3)
EPA Substance Registry System: 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester (94-05-3)

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Safety

Hazard Codes: Xi,T,Xn
Risk Statements: 36/37/38-42/43-41-37/38-22
Safety Statements: 26-37/39
RIDADR: 3276
WGK Germany: 1
Hazard Note: Toxic
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E28005
Product name: Ethyl 2-cyano-3-ethoxyacrylate
Purity: 98%
Packaging: 25g
Price: $50.73
Updated: 2025/07/31

Sigma-Aldrich

Product number: E28005
Product name: Ethyl 2-cyano-3-ethoxyacrylate
Purity: 98%
Packaging: 100g
Price: $54.05
Updated: 2025/07/31

TCI Chemical

Product number: E0341
Product name: Ethyl 2-(Ethoxymethylene)-2-cyanoacetate
Purity: >98.0%(GC)
Packaging: 25g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: E0341
Product name: Ethyl 2-(Ethoxymethylene)-2-cyanoacetate
Purity: >98.0%(GC)
Packaging: 500g
Price: $222
Updated: 2025/07/31

TRC

Product number: E907510
Product name: EthylCyano(ethoxymethylene)acetate
Packaging: 5g
Price: $50
Updated: 2021/12/16

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Ethyl (ethoxymethylene)cyanoacetate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline solid

Uses

Ethyl Cyano(ethoxymethylene)acetate is an intermediate in the synthesis of anti-inflammatory agents with gastroprotective effect in rats.

Synthesis

122-51-0

105-56-6

94-05-3

a) General procedure for the preparation of ethyl 4-(2-cyano-2-ethoxycarbonylvinylamino)benzoate: triethyl orthoformate (33.3 mL, 0.2 mol) was mixed with ethyl cyanoacetate (21.3 mL, 0.2 mol) in acetic acid anhydride (80 mL), and the mixture was heated for 5 hr at 150-160 °C. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to give ethyl 2-cyano-3-ethoxyacrylate as a yellow solid (28.5 g, 84% yield).

References

[1] Patent: US2006/4046, 2006, A1. Location in patent: Page/Page column 35
[2] Patent: WO2014/145986, 2014, A1. Location in patent: Paragraph 0274
[3] Arkivoc, 2017, vol. 2017, # 3, p. 73 - 86
[4] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 3, p. 591 - 599
[5] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 18

Ethyl (ethoxymethylene)cyanoacetate Preparation Products And Raw materials

Raw materials

Ethyl cyanoacetate

Preparation Products

Allopurinol 4-AMINO-5-CARBOXY-2-ETHYL-MERCAPTOPYRIMIDINE Ethyl 3-amino-4-pyrazolecarboxylate 5-CARBOXYCYTOSINE 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 5-HYDROXYMETHYLCYTOSINE

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Ethyl (ethoxymethylene)cyanoacetate Suppliers

Americas 1 Belgium 2 Canada 2 China 245 Europe 1 Germany 7 India 12 Italy 1 Japan 4 Slovakia 1 Switzerland 2 The Netherlands 1 United Kingdom 11 United States 40 Global 330

Hubei zhonglong Kangsheng Fine Chemical Co., Ltd

Tel: 027-027-83850178 18162590268
Fax: 027-83850178
Email: 1984393783@qq.com
Country: China
ProdList: 990
Advantage: 58

NORANA GROUP

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Email: service@nornachem.com
Country: China
ProdList: 4943
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
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Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

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View Lastest Price from Ethyl (ethoxymethylene)cyanoacetate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ethyl (ethoxymethylene)cyanoacetate 94-05-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-16

Shanghai UCHEM Inc.

Product: Ethyl cyano(ethoxymethylene)acetate 94-05-3
Price: US $40.00-240.00/g
Min. Order: 25g
Purity: 0.98
Supply Ability: 25kg
Release date: 2023-10-27

Hebei Chuanghai Biotechnology Co,.LTD

Product: Ethyl (ethoxymethylene)cyanoacetate 94-05-3
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-22

94-05-3, Ethyl (ethoxymethylene)cyanoacetateRelated Search:

Tris(trimethylsilyl)phosphate Ethyl 3-ethoxyacrylate POLY(ETHYL ACRYLATE) Ethyl acrylate Ethyl cellulose CHLOROETHANE Ethylbenzene Ethanol Ethyl acetate Ethyl cyanoformate Ethyl methacrylate ETHYL 2-CYANOACRYLATE Ethyl isocyanoacetate 1-Hydroxyethylidene-1,1-diphosphonic acid Ethyl N-cyanoethanimideate Ethyl cyanoglyoxylate-2-oxime acetic acid, triethoxy-, ethyl ester Cyanoacetic acid

Acrylic acid, 2-cyano-3-ethoxy-, ethyl ester

Ethyl (2E)-2-cyano-3-ethoxy-2-propenoate

Ethyl 3-ethoxy-2-cyanoacrylate

Ethyl alpha-(ethoxymethylene)-alpha-cyanoacetate

Ethyl cyano(ethoxymethylene)acetate

2-cyano-3-ethoxy-2-propenoicaciethylester

2-Propenoicacid,2-cyano-3-ethoxy-,ethylester

2-CYANO-3-ETHOXY-2-PROPENOIC ACID ETHYL ESTER

2-CYANO-3-ETHOXYACRYLIC ACID ETHYL ESTER

ETHYL 2-CYANO-3-ETHOXYACRYLATE FOR SYNTH

Ethyl 2-cyano-3-ethoxyacrylate 98%

2-(ETHOXYMETHYLENE)-2-CYANOACETIC ACID ETHYL ESTER

EMCAE

ETHOXY METHYLENE CYANOACETIC ACID ETHYL ESTER

ETHYL 2-(ETHOXYMETHYLENE)-2-CYANOACETATE

ETHYL 2-CYANO-3-ETHOXYACRYLATE

ETHYL (ETHOXYMETHYLENE)CYANOACETATE

Ethoxyl Methylene Cyanoacetic Ethyl

Ethyl-2-cyan-3-ethoxyacrylat

Ethyl (E)-2-cyano-3-ethoxyprop-2-enoate

2-Cyano-3-ethoxypropenoic acid ethyl ester

2-Ethoxymethylenecyanoacetic acid ethyl ester

3-Ethoxy-2-cyanopropenoic acid ethyl ester

Cyano(ethoxymethylene)acetic acid ethyl ester

Ethyl 2-ethoxymethylene-cyanoacetate

Ethyl(Ethoxymethylene)cyaoacetate

Ethyl 2-Cyano-3-ethoxyacrylate, 97+%

Ethoxy heartland of methyl ethyl cyano acetate

ethyl (Z)-2-cyano-3-ethoxyacrylate

Ethyl (ethoxymethylene)

(E)-ethyl 2-cyano-3-ethoxyacrylate

Ethyl 2-cyano-3-ethoxyprop-2-enoate, Ethyl (ethoxymethylene)cyanoacetate

Ethyl (ethoxyMethyle

2-Cyano-3-ethoxyacrylic Acid Ethyl Ester 2-(Ethoxymethylene)-2-cyanoacetic Acid Ethyl Ester Ethyl 2-Cyano-3-ethoxyacrylate

2-Cyano-3-ethoxyacryL

Ethyl2-(Ethoxymethylene)-2-cyanoacetate&gt

(ethoxymethylene)cyanoacetate

Neratinib Impurity 52

TIANFU-CHEM - Ethyl (ethoxymethylene)cyanoacetate

ethyl (2Z)-2-cyano-3-ethoxyprop-2-enoate

94-05-3

1994-5-3

1994-05-03

1994-05-3

C2H5OCHCCNCOOC2H5

Building Blocks

Carbonyl Compounds

C8 to C9

Esters

Organic Building Blocks

Aliphatic Compound

Pharmaceutical Intermediates

Building Blocks

C8 to C9

Carbonyl Compounds

Chemical Synthesis

Esters

Organic Building Blocks